Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver

Laboratory Investigation

Volumn 92, Issue 3, 2012, Pages 396-410

  Knockaert, Laetitia ^a,b   Berson, Alain ^c   Ribault, Catherine ^a,b   Prost, Pierre Emmanuel ^a,b   Fautrel, Alain ^a,b   Pajaud, Julie ^a,b   Lepage, Sylvie ^d   Lucas Clerc, Catherine ^e   Bégué, Jean Marc ^b,d,f   Fromenty, Bernard ^a,b   Robin, Marie Anne ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^d Service des Explorations Fonctionnelles   (France)

^e PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^f Service de Physiologie   (France)

Author keywords

antioxidant; carbon tetrachloride; cytochrome P450 2E1; hepatotoxicity; lipid peroxidation; mitochondria

Indexed keywords

ANTIOXIDANT; CARBON TETRACHLORIDE; CYTOCHROME C OXIDASE; CYTOCHROME P450 2E1; DIETHYLDITHIOCARBAMIC ACID; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; MESSENGER RNA; MITOCHONDRIAL DNA; PRASTERONE; TROLOX C;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL LEVEL; CELL SWELLING; CONTROLLED STUDY; DEPLETION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME ASSAY; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; LIVER CELL; LIVER INJURY; LIVER MITOCHONDRION; LIVER STRUCTURE; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY CHAIN;

ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE; CARBON TETRACHLORIDE POISONING; CHROMANS; CYTOCHROME P-450 CYP2E1; DEHYDROEPIANDROSTERONE; DITIOCARB; HEPATOCYTES; LIPID PEROXIDATION; MALE; MICE; MITOCHONDRIA, LIVER;

EID: 84857715739     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.193     Document Type: Article

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