Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

Archives of Biochemistry and Biophysics

Volumn 604, Issue , 2016, Pages 36-46

  Kurahashi, Toshihiro ^a,f   Lee, Jaeyong ^a   Nabeshima, Atsunori ^b   Homma, Takujiro ^a   Kang, Eun Sil ^a   Saito, Yuka ^a   Yamada, Sohsuke ^b,g   Nakayama, Toshiyuki ^b   Yamada, Ken Ichi ^c,d   Miyata, Satoshi ^e   Fujii, Junichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e OSAKA KOSEI NENKIN HOSPITAL   (Japan)

^f KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^g KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Acetaminophen; Amino acid transporter; Ascorbic acid; Autophagy; Glutathione

Indexed keywords

ALANINE AMINOTRANSFERASE; ALDEHYDE REDUCTASE; AMINO ACID TRANSPORTER; ASCORBIC ACID; GLUTATHIONE; GLUTATHIONE REDUCTASE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; CYSTEINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL VIABILITY; CONTROLLED STUDY; GLUTATHIONE METABOLISM; GUINEA PIG MODEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER CELL; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN CARBONYLATION; TOXIC HEPATITIS; VITAMIN SUPPLEMENTATION; ANIMAL; C57BL MOUSE; CHEMISTRY; CROSS BREEDING; DRUG EFFECTS; GENOTYPE; GUINEA PIG; KNOCKOUT MOUSE; LIVER; METABOLISM;

ACETAMINOPHEN; ALDEHYDE REDUCTASE; ANIMALS; ASCORBIC ACID; AUTOPHAGY; CROSSES, GENETIC; CYSTEINE; GENOTYPE; GLUTATHIONE; GUINEA PIGS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REACTIVE OXYGEN SPECIES;

EID: 84974849164     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2016.06.004     Document Type: Article

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