An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy

Biochemical and Biophysical Research Communications

Volumn 467, Issue 4, 2015, Pages 866-871

  Kurahashi, Toshihiro ^a   Hamashima, Shinji ^a   Shirato, Takaya ^a   Lee, Jaeyong ^a   Homma, Takujiro ^a   Kang, Eun Sil ^a   Fujii, Junichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Fasting; Lipophagy; Liver steatosis; Oxidative stress; Superoxide dismutase

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; FAT DROPLET; FATTY ACID; PROTEIN P62; UBIQUITIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENDOPLASMIC RETICULUM STRESS; LIPID LIVER LEVEL; LIPID STORAGE; LIPOPHAGOCYTOSIS; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONTENT; ANIMAL; C57BL MOUSE; CAPSULORHEXIS; DOWN REGULATION; ENDOPLASMIC RETICULUM; GENETICS; KNOCKOUT MOUSE; LIPID METABOLISM; LIPOGENESIS; LIVER; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CAPSULORHEXIS; DOWN-REGULATION; ENDOPLASMIC RETICULUM; FASTING; LIPID METABOLISM; LIPOGENESIS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SUPEROXIDE DISMUTASE;

EID: 84946560840     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.10.052     Document Type: Article

References (26)

1. G. Serviddio, F. Bellanti, and G. Vendemiale Free radical biology for medicine: learning from nonalcoholic fatty liver disease Free Radic. Biol. Med. 65 2013 952 968
2. I. Fridovich Superoxide radical and superoxide dismutases Annu. Rev. Biochem. 64 1995 97 112
3. S. Uchiyama, T. Shimizu, and T. Shirasawa CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice J. Biol. Chem. 281 2006 31713 31719
4. T. Kurahashi, T. Konno, N. Otsuki, M.S. Kwon, J. Ito, and J. Fujii A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice FEBS Lett. 586 2012 4289 4295
5. L. Wang, Z. Jiang, and X.G. Lei Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis Free Radic. Biol. Med. 53 2012 1689 1696
6. D.L. Fang, Y. Wan, W. Shen, J. Cao, Z.X. Sun, H.H. Yu, Q. Zhang, W.H. Cheng, J. Chen, and B. Ning Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells Mol. Cell. Biochem. 381 2013 127 137
7. U. Ozcan, Q. Cao, E. Yilmaz, A.-H. Lee, N.N. Iwakoshi, E. Ozdelen, G. Tuncman, C. Görgün, L.H. Glimcher, and G.S. Hotamisligil Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes Science 306 2004 457 461
8. J.D. Malhotra, and R.J. Kaufman Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox Signal 9 2007 2277 2293
9. M. Sekiya, A. Hiraishi, M. Touyama, and K. Sakamoto Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells Biochem. Biophys. Res. Commun. 375 2008 602 607
10. J. Ye, R.B. Rawson, R. Komuro, X. Chen, U.P. Davé, R. Prywes, M.S. Brown, and J.L. Goldstein ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs Mol. Cell 6 2000 1355 1364
11. J. Lee, T. Homma, T. Kurahashi, E.S. Kang, and J. Fujii Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis Biochem. Biophys. Res. Commun. 464 2015 1 7
12. R. Singh, S. Kaushik, Y. Wang, Y. Xiang, I. Novak, M. Komatsu, K. Tanaka, A.M. Cuervo, and M.J. Czaja Autophagy regulates lipid metabolism Nature 458 2009 1131 1135
13. A.S.S. Rambold, S. Cohen, and J. Lippincott-schwartz Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics Dev. Cell 32 2015 1 15
14. N.L. Trotter Electron-opaque bodies and fat droplets in mouse liver after fasting or glucose injection J. Cell Biol. 34 1967 703 711
15. N. Martinez-Lopez, and R. Singh Autophagy and Lipid Droplets in the Liver Annu. Rev. Nutr. 35 2015 215 237
16. K.L. Donnelly, C.I. Smith, S.J. Schwarzenberg, J. Jessurun, M.D. Boldt, and E.J. Parks Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J. Clin. Invest. 115 2005 1343 1351
17. Y. Iuchi, F. Okada, K. Onuma, T. Onoda, H. Asao, M. Kobayashi, and J. Fujii Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production Biochem. J. 402 2007 219 227
18. Y. Iuchi, T. Kaneko, S. Matsuki, T. Ishii, Y. Ikeda, K. Uchida, and J. Fujii Carbonyl stress and detoxification ability in the male genital tract and testis of rats Histochem. Cell Biol. 121 2004 123 130
19. S.G. Rhee, H.A. Woo, I.S. Kil, and S.H. Bae Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides J. Biol. Chem. 287 2012 4403 4410
20. N. Mizushima, T. Yoshimori, and B. Levine Methods in mammalian autophagy research Cell 140 2010 313 326
21. M. Komatsu, S. Waguri, M. Koike, Y.S. Sou, T. Ueno, T. Hara, N. Mizushima, J.I. Iwata, J. Ezaki, S. Murata, J. Hamazaki, Y. Nishito, S.I. Iemura, T. Natsume, T. Yanagawa, J. Uwayama, E. Warabi, H. Yoshida, T. Ishii, A. Kobayashi, M. Yamamoto, Z. Yue, Y. Uchiyama, E. Kominami, and K. Tanaka Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice Cell 131 2007 1149 1163
22. J. Kerner, and C. Hoppel Fatty acid import into mitochondria Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1486 2000 1 17
23. R. Singh, and A.M. Cuervo Autophagy in the cellular energetic balance Cell Metab. 13 2011 495 504
24. R. Scherz-Shouval, E. Shvets, E. Fass, H. Shorer, L. Gil, and Z. Elazar Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 EMBO J. 26 2007 1749 1760
25. M. Komatsu Liver autophagy: Physiology and pathology J. Biochem. 152 2012 5 15
26. Y. Nagaoka, K. Otsu, F. Okada, K. Sato, Y. Ohba, N. Kotani, and J. Fujii Specific inactivation of cysteine protease-type cathepsin by singlet oxygen generated from naphthalene endoperoxides Biochem. Biophys. Res. Commun. 331 2005 215 223