Nutritional stress induced by tryptophan-degrading enzymes results in ATF4-dependent reprogramming of the amino acid transporter profile in tumor cells

Cancer Research

Volumn 76, Issue 21, 2016, Pages 6193-6204

  Timosenko, Elina ^a   Ghadbane, Hemza ^a,e   Silk, Jonathan D ^a,f   Shepherd, Dawn ^a   Gileadi, Uzi ^a   Howson, Lauren J ^a   Laynes, Robert ^b   Zhao, Qi ^c,g   Strausberg, Robert L ^c   Olsen, Lars R ^d   Taylor, Stephen ^a   Buffa, Francesca M ^b   Boyd, Richard ^b   Cerundolo, Vincenzo ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^e Immunocore Limited   (United Kingdom)

^f Adaptimmune Ltd   (United Kingdom)

^g REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSPORTER; GLUTAMINE; PROTEIN SLC1A5; T LYMPHOCYTE RECEPTOR; TRYPTOPHAN 2,3 DIOXYGENASE; UNCLASSIFIED DRUG; ATF4 PROTEIN, HUMAN; INDOLEAMINE 2,3 DIOXYGENASE; MINOR HISTOCOMPATIBILITY ANTIGEN; SLC1A5 PROTEIN, HUMAN; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMIT OF QUANTITATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; NUTRITION; NUTRITIONAL STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; T LYMPHOCYTE; UPREGULATION; GENETICS; METABOLISM; NEOPLASM; PHYSIOLOGY; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSPORT SYSTEM ASC; AMINO ACID TRANSPORT SYSTEMS; CELL LINE, TUMOR; CELLULAR REPROGRAMMING; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MINOR HISTOCOMPATIBILITY ANTIGENS; NEOPLASMS; TRYPTOPHAN;

EID: 84995584898     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-3502     Document Type: Article

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