Impact of additives on the formation of protein aggregates and viscosity in concentrated protein solutions

International Journal of Pharmaceutics

Volumn 516, Issue 1-2, 2017, Pages 82-90

  Bauer, Katharina Christin ^a   Suhm, Susanna ^a   Wöll, Anna Katharina ^a   Hubbuch, Jürgen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

ArgHCl; Glycine; Microrheology; NaCl; Phase behavior; Protein conformation; Protein interactions

Indexed keywords

ARGININE; GLUCOSE OXIDASE; GLYCEROL; GLYCINE; LYSOZYME; MACROGOL; POLYETHYLENE GLYCOL 1000; POLYETHYLENE GLYCOL 300; PROTEIN AGGREGATE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; COLLOID; EXCIPIENT; SOLUTION AND SOLUBILITY;

ARTICLE; COLLOID; CONCENTRATION (PARAMETERS); DRUG FORMULATION; DYNAMICS; FLOW KINETICS; INFRARED SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STABILITY; VISCOSITY; CHEMISTRY; COMPARATIVE STUDY; MEDICINAL CHEMISTRY; PROCEDURES; SOLUTION AND SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; COLLOIDS; EXCIPIENTS; GLUCOSE OXIDASE; HYDROGEN-ION CONCENTRATION; MURAMIDASE; PHARMACEUTICAL SOLUTIONS; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEIN STABILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VISCOSITY;

EID: 84995578512     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.11.009     Document Type: Article

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