Effect of sugar molecules on the viscosity of high concentration monoclonal antibody solutions

Pharmaceutical Research

Volumn 28, Issue 7, 2011, Pages 1552-1560

  He, Feng ^a,b   Woods, Christopher E ^a   Litowski, Jennifer R ^a   Roschen, Lauren A ^a   Gadgil, Himanshu S ^a   Razinkov, Vladimir I ^a   Kerwin, Bruce A ^a,b  

^a AMGEN INC   (United States)

^b AW2/D3152 ^*  (United States)

Author keywords

dynamic light scattering; high throughput; monoclonal antibody; preferential exclusion; preferential hydration; sugar molecule; viscosity

Indexed keywords

FRUCTOSE; GALACTOSE; GLUCOSE; MACROGOL; MONOCLONAL ANTIBODY; SODIUM CHLORIDE; SORBITOL; SUCROSE; SUGAR; TREHALOSE; XYLOSE;

ARTICLE; CARBOHYDRATE ANALYSIS; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; FLUOROMETRY; HYDROPHOBICITY; IONIC STRENGTH; LIGHT SCATTERING; OSMOLALITY; PRIORITY JOURNAL; PROTEIN STABILITY; SALINITY; TEMPERATURE; VISCOSITY;

ANIMALS; ANTIBODIES, MONOCLONAL; CALORIMETRY, DIFFERENTIAL SCANNING; DISACCHARIDES; HUMANS; IONS; MOLECULAR STRUCTURE; SOLUTIONS; TEMPERATURE; VISCOSITY;

EID: 79959866680     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0388-7     Document Type: Article

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