Structure-activity relationship for hydrophobic salts as viscosity-lowering excipients for concentrated solutions of monoclonal antibodies

Pharmaceutical Research

Volumn 29, Issue 11, 2012, Pages 3102-3109

  Guo, Zheng ^a,c   Chen, Alvin ^b   Nassar, Roger A ^a   Helk, Bernhard ^d   Mueller, Claudia ^d   Tang, Yu ^e   Gupta, Kapil ^e   Klibanov, Alexander M ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology   (United States)

^c AARHUS UNIVERSITY   (Denmark)

^d NOVARTIS PHARMA AG   (Switzerland)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

excipients; monoclonal antibodies; proteins; rheology; salts; structure activity relationship (SAR); viscosity

Indexed keywords

ANION; AROMATIC COMPOUND; CATION; EXCIPIENT; INORGANIC ACID; MONOCLONAL ANTIBODY; SODIUM CHLORIDE; SULFONIC ACID DERIVATIVE;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CHEMICAL INTERACTION; CHEMICAL PROCEDURES; CONCENTRATION (PARAMETERS); DISSOLUTION; DRUG DETERMINATION; DRUG FORMULATION; DRUG SOLUTION; HYDROPHOBICITY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ROOM TEMPERATURE; STRUCTURE ACTIVITY RELATION; VISCOSITY;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CHO CELLS; CRICETINAE; EXCIPIENTS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IONS; PHARMACEUTICAL SOLUTIONS; SODIUM CHLORIDE; STRUCTURE-ACTIVITY RELATIONSHIP; VISCOSITY; WATER;

EID: 84867862132     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0802-9     Document Type: Article

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