Combined deficiency in glutathione peroxidase 4 and vitamin e causes multiorgan thrombus formation and early death in mice

Circulation Research

Volumn 113, Issue 4, 2013, Pages 408-417

  Wortmann, Markus ^a   Schneider, Manuela ^a   Pircher, Joachim ^a   Hellfritsch, Juliane ^a   Aichler, Michaela ^b   Vegi, Naidu ^d   Kölle, Pirkko ^a   Kuhlencordt, Peter ^a   Walch, Axel ^b   Pohl, Ulrich ^a   Bornkamm, Georg W ^e   Conrad, Marcus ^c   Beck, Heike ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Institute of Pathology   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY HOSPITAL ULM   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

tocopherol; endothelium, vascular; oxidant stress; thrombosis; vascular endothelial function

Indexed keywords

ALPHA TOCOPHEROL; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CELL DEATH; DEATH; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME DEFICIENCY; HEART FAILURE; HEMODYNAMIC PARAMETERS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KIDNEY DISEASE; KNOCKOUT MOUSE; LIPID PEROXIDATION; MOUSE; MULTIORGAN THROMBUS FORMATION; NONHUMAN; PRIORITY JOURNAL; SPLEEN DISEASE; VASCULAR RING; VITAMIN DEFICIENCY;

Α-TOCOPHEROL; ENDOTHELIUM, VASCULAR; OXIDANT STRESS; THROMBOSIS; VASCULAR ENDOTHELIAL FUNCTION;

ANIMALS; APOPTOSIS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FEMALE; GLUTATHIONE PEROXIDASE; HEART RATE; LIPID PEROXIDATION; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; OXIDATIVE STRESS; THROMBOSIS; VITAMIN E; VITAMIN E DEFICIENCY;

EID: 84881670256     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.279984     Document Type: Article

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