Relationships between chronic obstructive pulmonary disease and lung cancer: Biological insights

Journal of Thoracic Disease

Volumn 8, Issue 10, 2016, Pages E1122-E1135

  Barreiro, Esther ^a,b   Bustamante, Víctor ^c   Curull, Víctor ^a,b   Gea, Joaquim ^a,b   López Campos, José Luis ^b,d   Muñoz, Xavier ^b,e  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL DE BASURTO   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Chronic obstructive pulmonary disease (COPD); Epidemics; Etiologic agents; Lung cancer (LC); Underlying biological mechanisms

Indexed keywords

AIR POLLUTION; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIET; EMPHYSEMA; EPIDEMIC; GEOGRAPHIC DISTRIBUTION; HUMAN; IONIZING RADIATION; LUNG CANCER; NONHUMAN; OCCUPATIONAL EXPOSURE; OXIDATION REDUCTION STATE; PHYSICAL ACTIVITY; REVIEW; RISK ASSESSMENT; RISK FACTOR; SMOKING;

EID: 84995376655     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.21037/jtd.2016.09.54     Document Type: Review

References (124)

1. Alberg AJ, Ford JG, Samet JM, et al. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007;132:29S-55S
2. Ruano-Ravina A, Perez RM, Fernandez-Villar A. Lung cancer screening with low-dose computed tomography after the National Lung Screening Trial. The debate is still open. Arch Bronconeumol 2013;49:158-65
3. Sanchez-Salcedo P, Berto J, de-Torres JP, et al. Lung Cancer Screening: Fourteen Year Experience of the Pamplona Early Detection Program (P-IELCAP). Arch Bronconeumol 2015;51:169-76
4. Sanchez-Salcedo P, Wilson DO, de-Torres JP, et al. Improving selection criteria for lung cancer screening. The potential role of emphysema. Am J Respir Crit Care Med 2015;191:924-31
5. Sánchez de Cos-Escuín J. Prognostic Factors in Stage I Lung Cancer. Arch Bronconeumol 2015;51:427-8
6. Villar Álvarez F, Muguruza Trueba I, Vicente Antunes SI. Notes on Recurrence and Second Tumors in Lung Cancer. Arch Bronconeumol 2016;52:545-6
7. Doll R, Hill AB. Smoking and carcinoma of the lung; preliminary report. Br Med J 1950;2:739-48
8. Levin ML, Goldstein H, Gerhardt PR. Cancer and tobacco smoking; a preliminary report. J Am Med Assoc 1950;143:336-8
9. Wynder EL, Graham EA. Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. J Am Med Assoc 1950;143:329-36
10. Álvarez Martínez CJ, Bastarrika Alemañ G, Disdier Vicente C, et al. Guideline on management of solitary pulmonary nodule. Arch Bronconeumol 2014;50:285-93
11. Leiro-Fernández V, Mouronte-Roibas C, Ramos-Hernandez C, et al. Changes in clinical presentation and staging of lung cancer over two decades. Arch Bronconeumol 2014;50:417-21
12. Rodríguez M, Gómez Hernández MT, Novoa NM, et al. Poorer Survival in Stage IB Lung Cancer Patients After Pneumonectomy. Arch Bronconeumol 2015;51:223-6
13. Rodríguez M, Gómez Hernández MT, Novoa NM, et al. Morbidity and mortality in octogenarians with lung cancer undergoing pneumonectomy. Arch Bronconeumol 2015;51:219-22
14. Sánchez de Cos Escuín J, Serra Mitjans M, Hernández Hernández J, et al. The Spanish Society of Pulmonology and Thoracic Surgery Lung Cancer Cooperative Group-II registry. A descriptive study. Arch Bronconeumol 2013;49:462-7
15. Sánchez de Cos J, Hernández JH, López MF, et al. SEPAR guidelines for lung cancer staging. Arch Bronconeumol 2011;47:454-65
16. Gonzalez J, Marin M, Sanchez-Salcedo P, et al. Lung cancer screening in patients with chronic obstructive pulmonary disease. Ann Transl Med 2016;4:160
17. Leiro-Fernández V, Priegue Carrera A, Fernández-Villar A. Efficacy of Double Bronchodilation (LABA+LAMA) in Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer. Arch Bronconeumol 2016. [Epub ahead of print]
18. Gupta A, Srivastava S, Prasad R, et al. Oxidative stress in non-small cell lung cancer patients after chemotherapy: association with treatment response. Respirology 2010;15:349-56
19. Masri FA, Comhair SA, Koeck T, et al. Abnormalities in nitric oxide and its derivatives in lung cancer. Am J Respir Crit Care Med 2005;172:597-605
20. Pignatelli B, Li CQ, Boffetta P, et al. Nitrated and oxidized plasma proteins in smokers and lung cancer patients. Cancer Res 2001;61:778-84
21. Rahman I, Morrison D, Donaldson K, et al. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med 1996;154:1055-60
22. Rahman I, van Schadewijk AA, Crowther AJ, et al. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002;166:490-5
23. Álvarez FV, Trueba IM, Sanchis JB, et al. Recommendations of the Spanish Society of Pneumology and Thoracic Surgery on the diagnosis and treatment of non-small-cell lung cancer. Arch Bronconeumol 2016;52 Suppl 1:2-62
24. Villar Álvarez F, Muguruza Trueba I, Belda Sanchis J, et al. Executive summary of the SEPAR recommendations for the diagnosis and treatment of non-small cell lung cancer. Arch Bronconeumol 2016;52:378-88
25. Barreiro E, Fermoselle C, Mateu-Jimenez M, et al. Oxidative stress and inflammation in the normal airways and blood of patients with lung cancer and COPD. Free Radic Biol Med 2013;65:859-71
26. Mateu-Jiménez M, Sánchez-Font A, Rodríguez-Fuster A, et al. Redox imbalance in lung cancer of patients with underlying chronic respiratory conditions. Mol Med 2016. [Epub ahead of print]
27. Barnawi J, Tran HB, Roscioli E, et al. Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. COPD 2016;13:653-61
28. Bernardo I, Bozinovski S, Vlahos R. Targeting oxidantdependent mechanisms for the treatment of COPD and its comorbidities. Pharmacol Ther 2015;155:60-79
29. Kuznar-Kaminska B, Mikula-Pietrasik J, Sosinska P, et al. COPD promotes migration of A549 lung cancer cells: the role of chemokine CCL21. Int J Chron Obstruct Pulmon Dis 2016;11:1061-6
30. Marwick JA, Kirkham P, Gilmour PS, et al. Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells. Ann N Y Acad Sci 2002;973:278-83
31. Sohal SS, Mahmood MQ, Walters EH. Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer. Clin Transl Med 2014;3:33
32. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med 2008;359:1367-80
33. Esme H, Cemek M, Sezer M, et al. High levels of oxidative stress in patients with advanced lung cancer. Respirology 2008;13:112-6
34. Glasauer A, Sena LA, Diebold LP, et al. Targeting SOD1 reduces experimental non-small-cell lung cancer. J Clin Invest 2014;124:117-28
35. Grimm EA, Sikora AG, Ekmekcioglu S. Molecular pathways: inflammation-associated nitric-oxide production as a cancer-supporting redox mechanism and a potential therapeutic target. Clin Cancer Res 2013;19:5557-63
36. Mateu-Jiménez M, Cucarull-Martinez B, Yelamos J, et al. Reduced tumor burden through increased oxidative stress in lung adenocarcinoma cells of PARP-1 and PARP-2 knockout mice. Biochimie 2016;121:278-86
37. Miar A, Hevia D, Munoz-Cimadevilla H, et al. Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer. Free Radic Biol Med 2015;85:45-55
38. Doll R. Mortality from lung cancer among non-smokers. Br J Cancer 1953;7:303-12
39. Doll R, Peto R. Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J Epidemiol Community Health 1978;32:303-13
40. Garfinkel L, Stellman SD. Smoking and lung cancer in women: findings in a prospective study. Cancer Res 1988;48:6951-5
41. Lubin JH, Blot WJ, Berrino F, et al. Patterns of lung cancer risk according to type of cigarette smoked. Int J Cancer 1984;33:569-76
42. Sidney S, Tekawa IS, Friedman GD. A prospective study of cigarette tar yield and lung cancer. Cancer Causes Control 1993;4:3-10
43. Stellman SD, Garfinkel L. Lung cancer risk is proportional to cigarette tar yield: evidence from a prospective study. Prev Med 1989;18:518-25
44. Doll R, Peto R, Boreham J, et al. Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ 2004;328:1519
45. Charloux A, Quoix E, Wolkove N, et al. The increasing incidence of lung adenocarcinoma: reality or artefact? A review of the epidemiology of lung adenocarcinoma. Int J Epidemiol 1997;26:14-23
46. Vincent RG, Pickren JW, Lane WW, et al. The changing histopathology of lung cancer: a review of 1682 cases. Cancer 1977;39:1647-55
47. Furrukh M. Tobacco Smoking and Lung Cancer: Perception-changing facts. Sultan Qaboos Univ Med J 2013;13:345-58
48. Hirayama T. Non-smoking wives of heavy smokers have a higher risk of lung cancer: a study from Japan. Br Med J (Clin Res Ed) 1981;282:183-5
49. Trichopoulos D, Kalandidi A, Sparros L, et al. Lung cancer and passive smoking. Int J Cancer 1981;27:1-4
50. Peto R, Doll R, Buckley JD, et al. Can dietary betacarotene materially reduce human cancer rates? Nature 1981;290:201-8
51. Holick CN, Michaud DS, Stolzenberg-Solomon R, et al. Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. Am J Epidemiol 2002;156:536-47
52. Neuhouser ML, Patterson RE, Thornquist MD, et al. Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET). Cancer Epidemiol Biomarkers Prev 2003;12:350-8
53. Wright ME, Mayne ST, Swanson CA, et al. Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri women's health study (United States). Cancer Causes Control 2003;14:85-96
54. Bond GG, Thompson FE, Cook RR. Dietary vitamin A and lung cancer: results of a case-control study among chemical workers. Nutr Cancer 1987;9:109-21
55. Brennan P, Fortes C, Butler J, et al. A multicenter casecontrol study of diet and lung cancer among non-smokers. Cancer Causes Control 2000;11:49-58
56. Hu J, Mao Y, Dryer D, et al. Risk factors for lung cancer among Canadian women who have never smoked. Cancer Detect Prev 2002;26:129-38
57. Sebio R, Yanez-Brage MI, Gimenez-Moolhuyzen E, et al. Impact of a pre-operative pulmonary rehabilitation program on functional performance in patients undergoing video-assisted thoracic surgery for lung cancer. Arch Bronconeumol 2016;52:231-2
58. Guo J, Kauppinen T, Kyyronen P, et al. Occupational exposure to diesel and gasoline engine exhausts and risk of lung cancer among Finnish workers. Am J Ind Med 2004;45:483-90
59. Parent ME, Rousseau MC, Boffetta P, et al. Exposure to diesel and gasoline engine emissions and the risk of lung cancer. Am J Epidemiol 2007;165:53-62
60. Garshick E, Laden F, Hart JE, et al. Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect 2004;112:1539-43
61. Järvholm B, Silverman D. Lung cancer in heavy equipment operators and truck drivers with diesel exhaust exposure in the construction industry. Occup Environ Med 2003;60:516-20
62. Moitra S, Puri R, Paul D, et al. Global perspectives of emerging occupational and environmental lung diseases. Curr Opin Pulm Med 2015;21:114-20
63. Doll R. Mortality from lung cancer in asbestos workers. Br J Ind Med 1955;12:81-6
64. SelikoffIJ, Churg J, Hammond EC. Asbestos exposure and neoplasia. JAMA 1964;188:22-6
65. SelikoffIJ, Hammond EC, Seidman H. Mortality experience of insulation workers in the United States and Canada, 1943-1976. Ann N Y Acad Sci 1979;330:91-116
66. Churg A, Stevens B. Enhanced retention of asbestos fibers in the airways of human smokers. Am J Respir Crit Care Med 1995;151:1409-13
67. Hammond EC, SelikoffIJ, Seidman H. Asbestos exposure, cigarette smoking and death rates. Ann N Y Acad Sci 1979;330:473-90
68. Boice JD, Jr. Studies of atomic bomb survivors. Understanding radiation effects. JAMA 1990;264:622-3
69. Pierce DA, Sharp GB, Mabuchi K. Joint effects of radiation and smoking on lung cancer risk among atomic bomb survivors. Radiat Res 2003;159:511-20
70. Lubin JH, Boice JD Jr, Edling C, et al. Lung cancer in radon-exposed miners and estimation of risk from indoor exposure. J Natl Cancer Inst 1995;87:817-27
71. Ruano-Ravina A, Prini-Guadalupe L, Barros-Dios JM, et al. Exposure to residential radon and lung cancer in neversmokers: the preliminary results of the LCRINS study. Arch Bronconeumol 2012;48:405-9
72. Torres-Durán M, Ruano-Ravina A, Parente-Lamelas I, et al. Lung cancer in never-smokers: a case-control study in a radon-prone area (Galicia, Spain). Eur Respir J 2014;44:994-1001
73. Carazo Fernández L, Fernández Alvarez R, González-Barcala FJ, et al. Indoor air contaminants and their impact on respiratory pathologies. Arch Bronconeumol 2013;49:22-7
74. Chen X, Zhang LW, Huang JJ, et al. Long-term exposure to urban air pollution and lung cancer mortality: A 12-year cohort study in Northern China. Sci Total Environ 2016;571:855-61
75. Han B, Liu Y, You Y, et al. Assessing the inhalation cancer risk of particulate matter bound polycyclic aromatic hydrocarbons (PAHs) for the elderly in a retirement community of a mega city in North China. Environ Sci Pollut Res Int 2016. [Epub ahead of print]
76. Fang D, Wang Q, Li H, et al. Mortality effects assessment of ambient PM2.5 pollution in the 74 leading cities of China. Sci Total Environ 2016;569-570:1545-52
77. Tomczak A, Miller AB, Weichenthal SA, et al. Longterm exposure to fine particulate matter air pollution and the risk of lung cancer among participants of the Canadian National Breast Screening Study. Int J Cancer 2016;139:1958-66
78. Jaakkola MS, Samet JM. Occupational exposure to environmental tobacco smoke and health risk assessment. Environ Health Perspect 1999;107 Suppl 6:829-35
79. Palacio Nebreda MM, de Miguel-Diez J, Villegas Fernández FR, et al. Trends in the Incidence of Lung Cancer Hospitalizations in Spain, 2001-2011. Arch Bronconeumol 2016;52:411-9
80. Molina AJ, Garcia-Martinez L, Zapata-Alvarado J, et al. Trends in Lung Cancer Incidence in a Healthcare Area. Arch Bronconeumol 2015;51:e53-e55
81. Parente Lamelas I, Abal Arca J, Blanco Cid N, et al. Clinical characteristics and survival in never smokers with lung cancer. Arch Bronconeumol 2014;50:62-6
82. Fiorelli A, Costanzo S, di Costanzo E, et al. The early detection of lung cancer during follow-up of patients undergoing endobronchial one-way valve treatment for emphysema. Arch Bronconeumol 2015;51:e13-5
83. Monsó E, Montuenga LM, Sánchez de Cos J, et al. Biological Marker Analysis as Part of the CIBERES-RTIC Cancer-SEPAR Strategic Project on Lung Cancer. Arch Bronconeumol 2015;51:462-7
84. Peñalver Cuesta JC, Jordá Aragón C, Mancheño Franch N, et al. Prognostic Factors in Non-Small Cell Lung Cancer Less Than 3 Centimeters: Actuarial Analysis, Accumulative Incidence and Risk Groups. Arch Bronconeumol 2015;51:431-9
85. Gould MK. Clinical practice. Lung-cancer screening with low-dose computed tomography. N Engl J Med 2014;371:1813-20
86. de-Torres JP, Wilson DO, Sanchez-Salcedo P, et al. Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. Am J Respir Crit Care Med 2015;191:285-91
87. de Torres JP, Bastarrika G, Wisnivesky JP, et al. Assessing the relationship between lung cancer risk and emphysema detected on low-dose CT of the chest. Chest 2007;132:1932-8
88. Freixinet Gilart J, Rodríguez Suárez PM. Morbidity, mortality and survival after surgery for lung cancer. Arch Bronconeumol 2015;51:211-2
89. Sánchez de Cos Escuín J, Rodríguez López DP, Utrabo Delgado I, et al. Disease Recurrence and Second Tumors in Long-term Survivors of Lung Cancer. Arch Bronconeumol 2016;52:183-8
90. Andreo García F, Centeno Clemente Cá, Sanz Santos J, et al. Initial experience with real-time elastography using an ultrasound bronchoscope for the evaluation of mediastinal lymph nodes. Arch Bronconeumol 2015;51:e8-11
91. Casutt A, Prella M, Beigelman-Aubry C, et al. Fluoroscopic-Guided Radial Endobronchial Ultrasound Without Guide Sheath For Peripheral Pulmonary Lesions: A Safe And Efficient Combination. Arch Bronconeumol 2015;51:338-43
92. Fernández-Villar A, Mouronte-Roibás C, Botana-Rial M, et al. Ten Years of Linear Endobronchial Ultrasound: Evidence of Efficacy, Safety and Cost-effectiveness. Arch Bronconeumol 2016;52:96-102
93. García-Ortega A, Briones-Gómez A, Fabregat S, et al. Benefit of Chest Ultrasonography in the Diagnosis of Peripheral Thoracic Lesions in an Interventional Pulmonology Unit. Arch Bronconeumol 2016;52:244-9
94. Martín-Sánchez JC, Clèries R, Lidón-Moyano C, et al. Differences between Men and Women in Time Trends in Lung Cancer Mortality in Spain (1980-2013). Arch Bronconeumol 2016;52:316-20
95. Bao PP, Zheng Y, Wu CX, et al. Cancer incidence in urban Shanghai, 1973-2010: an updated trend and age-periodcohort effects. BMC Cancer 2016;16:284
96. Chen W, Zheng R, Zuo T, et al. National cancer incidence and mortality in China, 2012. Chin J Cancer Res 2016;28:1-11
97. Cho WC, Kwan CK, Yau S, et al. The role of inflammation in the pathogenesis of lung cancer. Expert Opin Ther Targets 2011;15:1127-37
98. O'Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy. Br J Cancer 2001;85:473-83
99. Xiao B, Liu H, Gu Z, et al. Expression of microRNA-133 inhibits epithelial-mesenchymal transition in lung cancer cells by directly targeting FOXQ1. Arch Bronconeumol 2016. [Epub ahead of print]
100. Bozinovski S, Vlahos R, Anthony D, et al. COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link. Br J Pharmacol 2016;173:635-48
101. Carpagnano GE, Spanevello A, Curci C, et al. IL-2, TNFalpha, and leptin: local versus systemic concentrations in NSCLC patients. Oncol Res 2007;16:375-81
102. Bozinovski S, Anthony D, Vlahos R. Targeting proresolution pathways to combat chronic inflammation in COPD. J Thorac Dis 2014;6:1548-56
103. Becker Y. Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy-a review. Virus Genes 2006;33:235-52
104. Conway EM, Pikor LA, Kung SH, et al. Macrophages, Inflammation, and Lung Cancer. Am J Respir Crit Care Med 2016;193:116-30
105. Landskron G, De la Fuente M, Thuwajit P, et al. Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res 2014;2014:149185
106. Li J, Wang Z, Mao K, et al. Clinical significance of serum T helper 1/T helper 2 cytokine shift in patients with nonsmall cell lung cancer. Oncol Lett 2014;8:1682-6
107. Scrimini S, Pons J, Sauleda J. Myeloid-Derived Suppressor Cells: Possible Link Between Chronic Obstrucive Pulmonary Disease and Lung Cancer. Arch Bronconeumol 2016;52:29-35
108. Montilla D, Pérez M, Borges L, et al. Soluble Human Leukocyte Antigen-G in the Bronchoalveolar Lavage of Lung Cancer Patients. Arch Bronconeumol 2016;52:420-4
109. Yuan A, Hsiao YJ, Chen HY, et al. Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression. Sci Rep 2015;5:14273
110. Biswas SK, Sica A, Lewis CE. Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J Immunol 2008;180:2011-7
111. Vlahos R, Bozinovski S. Role of alveolar macrophages in chronic obstructive pulmonary disease. Front Immunol 2014;5:435
112. Mittal V, El Rayes T, Narula N, et al. The Microenvironment of Lung Cancer and Therapeutic Implications. Adv Exp Med Biol 2016;890:75-110
113. Shen HJ, Sun YH, Zhang SJ, et al. Cigarette smokeinduced alveolar epithelial-mesenchymal transition is mediated by Rac1 activation. Biochim Biophys Acta 2014;1840:1838-49
114. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74
115. Young JF, Larsen LB, Malmendal A, et al. Creatineinduced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics. J Int Soc Sports Nutr 2010;7:9
116. Alam S, Li Z, Janciauskiene S, et al. Oxidation of Z alpha1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema. Am J Respir Cell Mol Biol 2011;45:261-9
117. Li Z, Alam S, Wang J, et al. Oxidized α1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema. Am J Physiol Lung Cell Mol Physiol 2009;297:L388-L400
118. Connor KM, Hempel N, Nelson KK, et al. Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Cancer Res 2007;67:10260-7
119. Hempel N, Carrico PM, Melendez JA. Manganese superoxide dismutase (Sod2) and redox-control of signaling events that drive metastasis. Anticancer Agents Med Chem 2011;11:191-201
120. Zhao Y, Wang B, Hu K, et al. Glutathione S-transferase theta1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies. Oncol Lett 2015;9:1947-53
121. Gallegos-Arreola MP, Gómez-Meda BC, Morgan-Villela G, et al. GSTT1 gene deletion is associated with lung cancer in Mexican patients. Dis Markers 2003-2004;19:259-61
122. Litwack G, Ketterer B, Arias IM. Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions. Nature 1971;234:466-7
123. Kasala ER, Bodduluru LN, Barua CC, et al. Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis. Biomed Pharmacother 2016;82:568-77
124. Menon S, Lu C, Menon R, et al. Effects of Antioxidants in Human Cancers: Differential Effects on Non-Coding Intronic RNA Expression. Antioxidants (Basel) 2016;5