Antioxidant and antitumor efficacy of Luteolin, a dietary flavone on benzo(a)pyrene-induced experimental lung carcinogenesis

Biomedicine and Pharmacotherapy

Volumn 82, Issue , 2016, Pages 568-577

  Kasala, Eshvendar Reddy ^a   Bodduluru, Lakshmi Narendra ^a   Barua, Chandana C ^b   Gogoi, Ranadeep ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b ASSAM AGRICULTURAL UNIVERSITY   (India)

Author keywords

Benzo(a)pyrene; Chemoprevention; Dietary flavone; Lung cancer; Luteolin

Indexed keywords

ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BENZO[A]PYRENE; CARCINOEMBRYONIC ANTIGEN; CATALASE; CYCLINE; CYTOCHROME P450 1A1; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID PEROXIDE; LUTEOLIN; SUPEROXIDE DISMUTASE; ENOLASE; TUMOR MARKER; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BENZO[A]PYRENE INDUCED EXPERIMENTAL LUNG CARCINOGENESIS; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL CARCINOGENESIS; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LUNG CARCINOGENESIS; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD; BODY WEIGHT; CARCINOGENESIS; CHEMISTRY; DIET; DRUG EFFECTS; ENZYMOLOGY; IMMUNOBLOTTING; LUNG; LUNG NEOPLASMS; METABOLISM; ORGAN SIZE; PATHOLOGY;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; BENZO(A)PYRENE; BIOMARKERS, TUMOR; BODY WEIGHT; CARCINOEMBRYONIC ANTIGEN; CARCINOGENESIS; DIET; IMMUNOBLOTTING; LIPID PEROXIDATION; LUNG; LUNG NEOPLASMS; LUTEOLIN; MALE; MICE; NEOPLASM PROTEINS; ORGAN SIZE; PHOSPHOPYRUVATE HYDRATASE;

EID: 84974659845     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.05.042     Document Type: Article

References (38)

1. Ferlay J., Ervik M., Dikshit R., Eser S., Mathers C. Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 2012, International Agency for Research on Cancer. GLOBOCAN, Lyon, France.
2. Penning T.M., Burczynski M.E., Hung C.F., McCoull K.D., Palackal N.T., Tsuruda L.S. Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. Chem. Res. Toxicol. 1999, 12:1-18.
3. Kasala E.R., Bodduluru L.N., Barua C.C., Shekhar S.C., Gogoi R. Benzo (a) pyrene induced lung cancer: role of dietary phytochemicals in chemoprevention. Pharmacol. Rep. 2015, 67(5):996-1009.
4. Bodduluru L.N., Kasala E.R., Thota N., Barua C.C., Sistla R. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol. In Vitro 2014, 28(5):1026-1035.
5. Kasala E.R., Bodduluru L.N., Madana R.M., Athira K.V., Gogoi R., Barua C.C. Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives. Toxicol. Lett. 2015, 233(2):214-225.
6. López-Lázaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev. Med. Chem. 2009, 9(1):31-59.
7. Seelinger G., Merfort I., Schempp C.M. Anti-oxidant, anti-inflammatory and anti-allergic activities of Luteolin. Planta Med. 2008, 74(14):1667-1677.
8. Lin Y., Shi R., Wang X., Shen H.M. Luteolin, a flavonoid with potentials for cancer prevention and Therapy. Curr. Cancer Drug Targets 2008, 8(7):634-646.
9. Kasala ER, Bodduluru LN, Barua CC, Madhana RM, Dahiaya, Budhania MK et al. Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. September 6, 2015. 10.1016/j.pharep.2015.08.014.
10. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95(2):351-358.
11. Rotruck J.T., Pope A.L., Ganther H.E., Swanson A.B., Hafeman D.G., Hoekstra W.G. Selenium biochemical role as a component of glutathione peroxidase. Science 1973, 179(4073):588-590.
12. Carlberg I., Mannervik B. Glutathione reductase. Methods Enzymol. 1985, 113:484-490.
13. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
14. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
15. Desai I.D. Vitamin E analysis methods for animal tissues. Methods Enzymol. 1984, 105:138-147.
16. Omaye S.T., Turnbull J.D., Sauberlich H.E. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. 1979, 62:3-11.
17. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
18. Boorman G.A. Pathology of the Fischer Rat: Reference and Atlas 1990, Academic Press.
19. Cherng J.M., Shieh D.E., Chiang W., Chang M.Y., Chiang L.C. Chemopreventive effects of minor dietary constituents in common foods on human cancer cells. Biosci. Biotechnol. Biochem. 2007, 71(6):1500-1504.
20. Rajendran P., Ekambaram G., Magesh V., Sakthisekaran D. Chemopreventive efficacy of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals. Environ. Toxicol. Pharmacol. 2008, 26(3):278-282.
21. Tessitore L., Costelli P., Baccino F.M. Pharmacological interference with tissue hypercatabolism in tumour-bearing rats. Biochem. J. 1994, 299:71-78.
22. Magesh V., Singh J.P., Selvendiran K., Ekambaram G., Sakthisekaran D. Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies. Mol. Cell. Biochem. 2006, 287(1-2):127-135.
23. Storz P. Reactive oxygen species in tumor progression. Front. Biosci. 2005, 10(1-3):1881-1896.
24. Kim H.S., Kwack S.J., Lee B.M. Lipid peroxidation, antioxidant enzymes, and benzo[a]pyrene-quinones in the blood of rats treated with benzo[a]pyrene. Chem. Biol. Interact. 2000, 127(2):139-150.
25. Sen C.K. Oxygen toxicity and antioxidants state of the art. Indian J. Physiol. Pharmacol. 1995, 39(3):177-196.
26. Ashokkumar P., Sudhandiran G. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed. Pharmcother. 2008, 62(9):590-597.
27. Ferrigno D., Buccheri G., Biggi A. Serum tumour markers in lung cancer: history, biology and clinical applications. Eur. Respir. J. 1994, 7(1):186-197.
28. Sakao Y., Tomimitsu S., Takeda Y., Natsuaki M., Itoh T. Carcinoembryonic antigen as a predictive factor for postoperative tumor relapse in early-stage lung adenocarcinoma. Eur. J. Cardiothorac. Surg. 2004, 25(4):520-522.
29. Quoix E., Purohit A., Faller-Beau M., Moreau L., Oster J.P., Pauli G. Comparative prognostic value of lactate dehydrogenase and neuron-specific enolase in small-cell lung cancer patients treated with platinum-based chemotherapy. Lung Cancer 2000, 30(2):127-134.
30. Foa P., Fornier M., Miceli R., Seregni E., Santambrogio L., Nosotti M., et al. Tumor markers CEA, NSE, SCC, TPA and CYFRA 21.1 in resectable non-small cell lung cancer. Anticancer Res. 1999, 19(4C):3613-3618.
31. Aggarwal B.B., Shishodia S., Sandur S.K., Pandey M.K., Sethi G. Inflammation and cancer: how hot is the link?. Biochem. Pharmacol. 2006, 72:1605-1621.
32. Pantano C., Reynaert N.L., Van der Vliet A., Janssen-Heininger Y.M. Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway. Antioxid. Redox Signal. 2006, 8:1791-1806.
33. Hida T., Yatabe Y., Achiwa H., Muramatsu H., Kozaki K., Nakamura S., et al. Increased expression of cyclooxygenase-2 occurs frequently in human lung cancer, specifically in adenocarcinomas. Cancer Res. 1998, 58(17):3761-3764.
34. Bravo R., Frank R., Blundell P.A., Macdonald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 1987, 326(6112):515-517.
35. Dworakowska D., Gózdz S., Jassem E., Badzio A., Kobierska G., Urbaniak A., et al. Prognostic relevance of proliferating cell nuclear antigen and p53 expression in non-small cell lung cancer. Lung Cancer 2002, 35(1):35-41.
36. Ashokkumar P., Sudhandiran G. Luteolin inhibits cell proliferation during azoxymethane-induced experimental colon carcinogenesis via Wnt/β-catenin pathway. Invest. New Drugs 2011, 29(2):273-284.
37. Bodduluru L.N., Kasala E.R., Barua C.C., Madhana M.R., Hussain I., Borah P. Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NF-κB and PCNA expression. Int. Immunopharmacol. 2016, 30:102-110.
38. Bodduluru L.N., Kasala E.R., Barua C.C., Karnam K.C., Vicky D., Maheswara E. Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Chem. Biol. Interact. 2015, 242:345-352.