Oxidation of Z α 1-antitrypsin by cigarette smoke induces polymerization: A novel mechanism of early-onset emphysema

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 2, 2011, Pages 261-269

  Alam, Sam ^a   Li, Zhenjun ^a   Janciauskiene, Sabina ^b   Mahadeva, Ravi ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Chronic obstructive pulmonary disease; Cigarette smoke; Oxidation; Polymerization; SERPINA1

Indexed keywords

ACETYLCYSTEINE; ALPHA 1 ANTITRYPSIN; CIGARETTE SMOKE; LEUKOCYTE ELASTASE; OXIDIZED ALPHA 1 ANTITRYPSIN; POLYMER; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HOMOZYGOTE; HUMAN; INFLAMMATORY CELL; LUNG EMPHYSEMA; LUNG HOMOGENATE; LUNG LAVAGE; MOLECULAR INTERACTION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATION; POLYMERIZATION; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN PURIFICATION;

ACETYLCYSTEINE; ALPHA 1-ANTITRYPSIN; ANIMALS; ANTIOXIDANTS; BRONCHOALVEOLAR LAVAGE FLUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MICE; MICE, INBRED CBA; MICE, TRANSGENIC; NEUTROPHILS; POLYMERIZATION; PROTEIN CONFORMATION; PULMONARY EMPHYSEMA; SMOKING; SUCCINIMIDES;

MUS;

EID: 80051635385     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0328OC     Document Type: Article

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