Advances in allergen immunotherapy in 2015

Journal of Allergy and Clinical Immunology

Volumn 138, Issue 5, 2016, Pages 1284-1291

  Bush, Robert K ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Allergen immunotherapy; clinical trials; immunotherapy

Indexed keywords

ALLERGEN; GRASS POLLEN EXTRACT; PEPTIDE VACCINE; BIOLOGICAL MARKER; VACCINE;

ALLERGIC RHINITIS; ASTHMA; CONTROLLED CLINICAL TRIAL (TOPIC); FOOD ALLERGY; HUMAN; IMMUNOTHERAPY; META ANALYSIS (TOPIC); ORAL IMMUNOTHERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SUBLINGUAL IMMUNOTHERAPY; ANIMAL; DESENSITIZATION; FOOD HYPERSENSITIVITY; RHINITIS, ALLERGIC;

ANIMALS; ASTHMA; BIOMARKERS; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS; RHINITIS, ALLERGIC; VACCINES;

EID: 84994910831     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.09.007     Document Type: Review

References (55)

1. 1 Bacchert, C., Larché, M., Bonini, S., Canonica, G.W., Kundig, T., Larenas-Linnemann, D., et al. Allergen immunotherapy on the way to product-based evaluation—a WAO statement. World Allergy Organ J, 8, 2015, 29.
2. 2 Tabatabaian, F., Casale, T.B., Selection of patients for sublingual immunotherapy (SLIT) versus subcutaneous umminotherapy (SCIT). Allergy Asthma Proc 36 (2015), 100–104.
3. 3 Pitsios, C., Demoly, P., Bilò, M.B., Gerth van Wijk, R., Pfaar, O., Sturm, G.J., et al. Clinical contraindications to allergen immunotherapy: an EAACI position paper. Allergy 70 (2015), 897–909.
4. 4 Jutel, M., Agache, I., Bonini, S., Burks, A.W., Calderon, M., Canonica, W., et al. International consensus on allergy immunotherapy. J Allergy Clin Immunol 136 (2015), 556–568.
5. 5 Mondoulet, L., Dioszeghy, V., Puteaux, E., Ligouis, M., Dhelft, V., Plaquet, C., et al. Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model. J Allergy Clin Immunol 135 (2015), 1546–1557.e4.
6. 6 Siebeneicher, S., Reuter, S., Wangorsch, A., Krause, M., Foetisch, K., Heinz, A., et al. Epicutaneous immunotherapy with a hypoallergenic Bet v 1 suppresses allergic asthma in a murine model. Allergy 70 (2015), 1559–1568.
7. 7 Senti, G., von Moos, S., Tay, F., Graf, N., Johansen, P., Kündig, T.M., Determinants of efficacy and safety in epicutaneous allergen immunotherapy: summary of three clinical trials. Allergy 70 (2015), 707–710.
8. 8 Senti, G., Kündig, T.M., Intralymphatic immunotherapy. World Allergy Organ J, 8, 2015, 9.
9. 9 Fox, E., Torrero, M.N., Evans, H., Mitre, E., Immunologic characterization of 3 murine regimens of allergen-specific immunotherapy. J Allergy Clin Immunol 135 (2015), 1341–1351.
10. 10 Wollmann, E., Lupinek, C., Kundi, M., Selb, R., Niederberger, V., Valenta, R., Reduction in allergen-specific IgE binding as measured by microarray: a possible surrogate marker for effects of specific immunotherapy. J Allergy Clin Immunol 136 (2015), 806–809.
11. 11 Shamji, M.H., Leyhadi, J.A., Scadding, G.W., Cheung, D.K., Calderon, M.A., Turka, L.A., et al. Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response. J Allergy Clin Immunol 135 (2015), 913–9121.e9.
12. 12 Martinez-Botas, J., Rodriguez-Álvarez, M., Cerecedo, I., Vlaicu, C., Diéguez, M.C., Gómez-Coronado, D., et al. Identification of novel peptide biomarkers to predict safety and efficacy of cow's milk oral immunotherapy by peptide microarray. Clin Exp Allergy 45 (2015), 1071–1084.
13. 13 Sastre, J., Rodríguez, F., Campo, P., Laffond, E., Marín, A., Alonso, M.D., Adverse reactions to immunotherapy are associated with different patterns of sensitization to grass allergens. Allergy 70 (2015), 598–600.
14. 14 Subbarayal, B., Schiller, D., Möbs, C., Pfützner, W., Jahn-Schmid, B., Gepp, B., et al. The diversity of Bet v 1–specific IgG4 antibodies remains mostly constant during the course of birch pollen immunotherapy. J Allergy Clin Immunol 136 (2015), 1680–1682.
15. 15 Dodev, T.S., Bowen, H., Shamji, M.H., Bax, H.J., Beavil, A.J., McDonnell, J.M., et al. Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class. Allergy 70 (2015), 720–724.
16. 16 Calderón, M.A., Kleine-Tebbe, J., Linneberg, A., De Blay, F., Hernandez Fernandez de Rojas, D., Virchow, J.C., et al. House dust mite respiratory allergy: an overview of current therapeutic strategies. J Allergy Clin Immunol Prect 3 (2015), 843–855.
17. 17 Liao, W., Hu, Q., Shen, L.L., Hu, Y., Tao, H.F., Li, H.F., et al. Sublingual immunotherapy for asthmatic children sensitized to house dust mite: a meta-analysis. Medicine (Baltimore), 94, 2015, E701.
18. 18 Di Bona, D., Plaia, A., Leto-Barone, M.S., La Piana, S., Di Lorenzo, G., Efficacy of grass pollen allergen sublingual immunotherapy tablets for seasonal allergy rhinoconjunctivitis: a systematic review and meta-analysis. JAMA Intern Med 175 (2015), 1301–1309.
19. 19 Nony, E., Bouley, J., Le Mignon, M., Lemoine, P., Jain, K., Horiot, S., et al. Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen-allergic patients. Allergy 70 (2015), 795–804.
20. 20 Maloney, J., Durham, S., Skoner, D., Dahl, R., Bufe, A., Bernstein, D., et al. Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma. Allergy 70 (2015), 302–309.
21. 21 Scadding, G.W., Eifan, A.O., Lao-Araya, M., Penagos, M., Poon, S.Y., Steveling, E., et al. Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge. Allergy 70 (2015), 689–696.
22. 22 Zidarn, M., Košnik, M., Šilar, M., Bajrović, N., Korošec, P., Sustained effect of grass pollen subcutaneous immunotherapy on suppression of allergen-specific basophil response; a real-life, nonrandomized controlled study. Allergy 70 (2015), 547–555.
23. 23 Rosner-Friese, K., Kaul, S., Vieths, S., Pfaar, O., Environmental exposure chambers in allergen immunotherapy trials; current status and clinical validation needs. J Allergy Clin Immunol 135 (2015), 636–643.
24. 24 Nolte, H., Maloney, J., Nelson, H.S., Berstein, D.I., Lu, S., Li, Z., et al. Onset and dose-related efficacy of house dust mite sublingual immunotherapy in an environmental exposure chamber. J Allergy Clin Immunol 135 (2015), 1494–1501.e6.
25. 25 Schmitt, J., Schwarz, K., Stadler, E., Wüstenberg, E.G., Allergy immunotherapy for allergic rhinitis effectively prevents asthma: results from a large retrospective cohort study. J Allergy Clin Immunol 136 (2015), 1511–1516.
26. 26 Gómez, E., Fernández, T.D., Doña, I., Rondon, C., Campo, P., Gomez, F., et al. Initial immunological changes as predictors for house dust mite immunotherapy response. Clin Exp Allergy 45 (2015), 1542–1553.
27. 27 Zolkipli, Z., Roberts, G., Cornelius, V., Clayton, B., Pearson, S., Michaelis, L., et al. Randomized controlled trial of primary prevention of atopy using house dust mite ORAI immunotherapy in early childhood. J Allergy Clin Immunol 136 (2015), 1541–1547.
28. 28 Chien, C.H., Yu, H.H., Chiang, B.L., Single allergen induced oral tolerance inhibits airway inflammation in conjugated allergen mice. J Allergy Clin Immunol 136 (2015), 1110–1113.e4.
29. 29 Nagai, Y., Shiraishi, D., Tanaka, Y., Nagasawa, Y., Ohwada, S., Shimauchi, H., et al. Transportation of sublingual antigens across sublingual ductal epithelial cells to the ductal antigen presenting cells in mice. Clin Exp Allergy 45 (2015), 677–686.
30. 30 Mascarell, L., Rak, S., Worm, M., Melac, M., Soulie, S., Lescaille, G., et al. Characterization of oral immune cells in birch pollen-allergic patients” impact of the oral allergy syndrome and sublingual allergen immunotherapy on antigen-presenting cells. Allery 70 (2015), 408–419.
31. 31 Böhm, L., Maxeiner, J., Meyer-Martin, H., Reuter, S., Finotto, S., Klein, M., et al. IL-10 and regulatory T-cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma. J Immunol 194 (2015), 887–897.
32. 32 Akdis, C.A., Akdis, M., Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens. J Immunol, 8, 2015, 17.
33. 33 Nelson, H., Cartier, S., Allen-Ramey, F., Lawton, S., Calderon, M.A., Network meta-analysis shows commercialized subcutaneous and sublingual grass products have comparable efficacy. J Allergy Clin Immunol Pract 3 (2015), 256–266.e3.
34. 34 Moreno Benítez, F., Espinazo Romeu, M., Letrán Camacho, A., Mas, S., García-Còzar, F.J., Tabar, A., Variation in allergen content in sublingual allergen immunotherapy with house dust mites. Allergy 70 (2015), 1413–1420.
35. 35 Bouchaud, G., Braza, F., Chesné, J., Lair, D., Chea, K.-W., Rolland-Debord, C., et al. Prevention of allergic asthma through DER p2 peptide vaccination. J Allergy Clin Immunol 136 (2015), 197–200.e1.
36. 36 Linhart, B., Focke-Tejkl, M., Weber, M., Narayanan, M., Neubauer, A., Mayrhofer, H., et al. Molecular evolution of hypoallergenic hybrid proteins for vaccination against grass pollen allergy. J Immunol 194 (2015), 4008–4018.
37. 37 Focke-Tejkl, M., Weber, M., Niespodziana, K., Newbaurer, A., Huber, H., Henning, R., et al. Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy. J Allergy Clin Immunol 135 (2015), 1207–1217.
38. 38 Niederberger, V., Marth, K., Eckl-Dorna, J., Foicke-Tejk, M., Weber, M., Hemmer, W., et al. Skin test evaluation of a novel peptide carrier-based vaccine BM32 in grass pollen-allergic patients. J Allergy Clin Immunol 136 (2015), 1101–1103.e8.
39. 39 Prickett, S.R., Rolland, J.M., O'Heir, R.E., Immunoregulatory T cell epitope peptides: the new frontier in allergy therapy. Clin Exp Allergy 45 (2015), 1015–1026.
40. 40 Worm, M., SPIREs: a new horizon for allergic disease treatment?. Expert Rev Clin Immunol 11 (2015), 1173–1175.
41. 41 Couroux, P., Patel, D., Armstrong, K., Larché, M., Hafner, R.P., Fel d 1-derived synthetic peptide immune-regulator epitopes show a long-term treatment effect in cat allergic subjects. Clin Exp Allergy 45 (2015), 974–981.
42. 42 Burks, A.W., Wood, R.A., Jones, S., Sicherer, S., Fleischer, D.M., Scurlock, A.M., et al. Sublingual immunotherapy for peanut allergy: long-term follow-up of a randomized multicenter trial. J Allergy Clin Immunol 135 (2015), 1240–1248.
43. 43 Nariesety, S.D., Frischmeyer-Gurrerio, P.A., Keet, C.A., Gorelik, M., Schroeder, J., Hamilton, R.G., et al. A randomized, double-blind placebo-controlled pilot study of sublingual versus immunotherapy for the treatment of peanut allergy. J Allergy Clin Immunol 135 (2015), 1275–1282.
44. 44 Gorelik, M., Nariesty, S.D., Guerrerio, A.L., Chichesters, K.L., Keet, C.A., Bieneman, A.P., et al. Suppression of the immunologic response to peanut during immunotherapy is often transient. J Allergy Clin Immunol 135 (2015), 1283–1292.
45. 45 Tang, M.L., Ponsonby, A.L., Orsini, F., Tey, D., Robinson, M., Su, E.L., et al. Administration of a probiotic with peanut oral immunotherapy: a randomized trial. J Allergy Clin Immunol 135 (2015), 737–744.e8.
46. 46 Patil, S.U., Ogunniyi, A.O., Calatroni, A., Tadigotla, V.R., Ruiter, B., Ma, A., et al. Peanut oral immunotherapy transiently expands circulation Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. J Allergy Clin Immunol 136 (2015), 125–134.e12.
47. 47 Begin, P., Nadeau, K.C., Changes in peanut specific T-cell clonotype with oral immunotherapy. J Allergy Clin Immunol 135 (2015), 1636–1638.
48. 48 Wisniewski, J.A., Commins, S.P., Agrawal, R., Hulse, K.E., Yu, M.D., Cronin, J., et al. Analysis of cytokine production by peanut-reactive T cells identifies residual th2 effectors in highly allergic children who received peanut oral immunotherapy. Clin Exp Allergy 45 (2015), 1201–1213.
49. 49 Goldberg, M.R., Nachshon, L., Appel, M.Y., Elizar, A., Levy, M.B., Eisenberg, E., et al. Efficacy of backed milk oral immunotherapy in backed milk-reactive allergic patients. J Allergy Clin Immunol 136 (2015), 1601–1606.
50. 50 Kuitunen, M., Englund, H., Remes, S., Movérare, R., Pelkonen, A., Borres, M.P., et al. High IgE levels to α-lactalbumin, β-lactoglobulin and casein predict less successful cow's milk oral immunotherapy. Allergy 70 (2015), 955–962.
51. 51 Caminiti, L., Pajno, G.B., Crisafulli, G., Chiera, F., Collura, M., Panasci, G., et al. Oral immunotherapy for egg allergy: a double-blind placebo-controlled study with post-desensitization follow-up. J Allergy Clin Immunol Pract 3 (2015), 532–539.
52. 52 Sato, S., Utsunomiya, T., Imai, T., Yanagida, N., Wheat oral immunotherapy for wheat-induced anaphylaxis. J Allergy Clin Immunol 136 (2015), 1131–1133.e7.
53. 53 Douladiris, N., Linhart, B., Swoboda, I., Gstöttner, A., Vassilopoulou, E., Stolz, F., et al. In vivo allergenic activity of a hypo-allergenic mutant of the major fish allergen Cyp c1 evaluate by means of skin testing. J Allergy Clin Immunol 136 (2015), 493–495.e8.
54. 54 Nowak-Wagrzyn, A., Albin, S., Oral immunotherapy for food allergy: mechanisms and role in management. Clin Exp Allergy 45 (2015), 368–383.
55. 55 Werfel, T., Asero, R., Ballmer-Weber, B.K., Beyer, K., Enrique, E., Knulst, A.C., et al. Position paper of the EAACI: food allergy due to immunological cross reactions with common inhalant allergens. Allergy 70 (2015), 1079–1090.