Reduction in allergen-specific IgE binding as measured by microarray: A possible surrogate marker for effects of specific immunotherapy

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 3, 2015, Pages 806-809.e7

  Wollmann, Eva ^a   Lupinek, Christian ^a   Kundi, Michael ^b   Selb, Regina ^b   Niederberger, Verena ^b   Valenta, Rudolf ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; BET V 1 ALLERGEN, BETULA; BIOLOGICAL MARKER; PLANT ANTIGEN; PROTEIN BINDING;

ALLERGY RAPID TEST; CLINICAL TRIAL (TOPIC); DISEASE MARKER; HUMAN; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOTHERAPY; LETTER; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROVOCATION TEST; ADULT; BIOSYNTHESIS; BIRCH; CHEMISTRY; CLINICAL TRIAL; DESENSITIZATION; DEVICES; DOUBLE BLIND PROCEDURE; FEMALE; IMMUNOLOGICAL MONITORING; IMMUNOLOGY; MALE; MIDDLE AGED; PATHOLOGY; PROCEDURES; PROTEIN MICROARRAY; RHINITIS, ALLERGIC, SEASONAL;

ADULT; ALLERGENS; ANTIGENS, PLANT; BETULA; BIOMARKERS; DESENSITIZATION, IMMUNOLOGIC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; MONITORING, IMMUNOLOGIC; PROTEIN ARRAY ANALYSIS; PROTEIN BINDING; RHINITIS, ALLERGIC, SEASONAL;

EID: 84941188592     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.02.034     Document Type: Article

References (15)

1. S. Dreborg, T.H. Lee, A.B. Kay, and S.R. Durham Immunotherapy is allergen-specific: a double-blind trial of mite or timothy extract in mite and grass dual-allergic patients Int Arch Allergy Immunol 158 2012 63 70
2. V. Niederberger, F. Horak, S. Vrtala, S. Spitzauer, M.T. Krauth, P. Valent, and et al. Vaccination with genetically engineered allergens prevents progression of allergic disease Proc Natl Acad Sci U S A 101 2004 14677 14682
3. G. Pauli, T.H. Larsen, S. Rak, F. Horak, E. Pastorello, R. Valenta, and et al. Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis J Allergy Clin Immunol 122 2008 951 960
4. M.H. Shamji, and S.R. Durham Mechanisms of immunotherapy to aeroallergens Clin Exp Allergy 41 2011 1235 1246
5. L.M. Lichtenstein, K. Ishizaka, P.S. Norman, A.K. Sobotoka, and B.M. Hill IgE antibody measurements in ragweed hay fever J Clin Invest 52 1973 472 482
6. M.H. Shamji, L.K. Wilcock, P.A. Wachholz, R.J. Dearman, I. Kimber, P.A. Wurtzen, and et al. The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses J Immunol Methods 317 2006 71 79
7. C. Lupinek, E. Wollmann, A. Baar, S. Banerjee, H. Breiteneder, B.M. Broecker, and et al. Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip Methods 66 2014 106 119
8. V. Mahler, S. Vrtala, O. Kuss, T.L. Diepgen, R. Suck, O. Cromwell, and et al. Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1 Clin Exp Allergy 34 2004 115 122
9. S.R. Durham, W.H. Yang, M.R. Pedersen, N. Johansen, and S. Rak Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis J Allergy Clin Immunol 117 2006 802 809
10. J. Reisinger, F. Horak, G. Pauli, M. van Hage, O. Cromwell, F. Konig, and et al. Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity J Allergy Clin Immunol 116 2005 347 354
11. V. Niederberger, F. Horak, S. Vrtala, S. Spitzauer, M.T. Krauth, P. Valent, and et al. Vaccination with genetically engineered allergens prevents progression of allergic disease Proc Natl Acad Sci U S A 101 2004 14677 14682
12. S. Vrtala, K. Hirtenlehner, L. Vangelista, A. Pastore, H.G. Eichler, W.R. Sperr, and et al. Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy J Clin Invest 99 1997 1673 1681
13. S. Vrtala, K. Hirtenlehner, M. Susani, M. Akdis, F. Kussebi, C.A. Akdis, and et al. Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen Bet v 1 FASEB J 15 2001 2045 2047
14. J. Reisinger, F. Horak, G. Pauli, M. van Hage, O. Cromwell, F. Konig, and et al. Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity J Allergy Clin Immunol 116 2005 347 354
15. C. Lupinek, E. Wollmann, A. Baar, S. Banerjee, H. Breiteneder, B.M. Broecker, and et al. Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip Methods 66 2014 106 119