A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 5, 2015, Pages 1275-1282.e6

  Narisety, Satya D ^a   Frischmeyer Guerrerio, Pamela A ^b   Keet, Corinne A ^b   Gorelik, Mark ^b   Schroeder, John ^b   Hamilton, Robert G ^b   Wood, Robert A ^b  

^a RUTGERS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

food allergy; immunotherapy; oral immunotherapy; Peanut allergy; sublingual immunotherapy

Indexed keywords

ADRENALIN; ANTIHISTAMINIC AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; PEANUT EXTRACT; PLACEBO; ALLERGEN; IMMUNOGLOBULIN G;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG WITHDRAWAL; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAINTENANCE THERAPY; MALE; ORAL IMMUNOTHERAPY; PEANUT ALLERGY; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN MANIFESTATION; SKIN TEST; SUBLINGUAL IMMUNOTHERAPY; TREATMENT DURATION; ADVERSE EFFECTS; ARACHIS; BLOOD; CLINICAL TRIAL; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; PEANUT HYPERSENSITIVITY; PROCEDURES; SUBLINGUAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADMINISTRATION, SUBLINGUAL; ADOLESCENT; ALLERGENS; ARACHIS; CHILD; DESENSITIZATION, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; MALE; PEANUT HYPERSENSITIVITY; PILOT PROJECTS; SKIN TESTS; TREATMENT OUTCOME;

EID: 84937932956     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.11.005     Document Type: Article

References (22)

1. S.H. Sicherer Epidemiology of food allergy J Allergy Clin Immunol 127 2011 594 602
2. S.H. Sicherer, A. Munoz-Furlong, J.H. Godbold, and H.A. Sampson US prevalence self-reported peanut, tree nut, and sesame allergy: 11-year follow-up J Allergy Clin Immunol 125 2010 1322 1326
3. A.H. Liu, R. Jaramillo, S.H. Sicherer, R.A. Wood, S.A. Bock, A.W. Burks, and et al. National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006 J Allergy Clin Immunol 126 2010 798 806
4. K.D. Jackson, L.D. Howie, and L.J. Akinbami Trends in allergic conditions among children: United States 1997-2011 NCHS Data Brief 121 2013 1 8
5. S.H. Sicherer, A. Munoz-Furlong, J.H. Godbold, and H.A. Sampson US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up J Allergy Clin Immunol 125 2010 1322 1326
6. M. Rinaldi, L. Harnack, C. Oberg, P. Schreiner, J. St Sauver, and L.L. Travis Peanut allergy diagnoses among children residing in Olmsted County, Minnesota J Allergy Clin Immunol 130 2012 945 950
7. D.L. Neuman-Sunshine, J.A. Eckman, C.A. Keet, E.C. Matsui, R.D. Peng, P.J. Lenehan, and et al. The natural history of persistent peanut allergy Ann Allergy Asthma Immunol 108 2012 326 331.e3
8. S.H. Sicherer, A.W. Burks, and H.A. Sampson Clinical features of acute allergic reactions to peanut and tree nuts in children Pediatrics 102 1998 e6
9. H.A. Sampson, A. Munoz-Furlong, S.A. Bock, C. Schmitt, R. Bass, B.A. Chowdhury, and et al. Symposium on the definition and management of anaphylaxis: summary report J Allergy Clin Immunol 115 2005 584 591
10. H.S. Skolnick, M.K. Conover-Walker, C.B. Koerner, H.A. Sampson, W. Burks, and R.A. Wood The natural history of peanut allergy J Allergy Clin Immunol 107 2001 367 374
11. A.T. Clark, S. Islam, Y. King, J. Deighton, K. Anagnostou, and P.W. Ewan Successful oral tolerance induction in severe peanut allergy Allergy 64 2009 1218 1220
12. S.M. Jones, L. Pons, J.L. Roberts, A.M. Scurlock, T.T. Perry, M. Kulis, and et al. Clinical efficacy and immune regulation with peanut oral immunotherapy J Allergy Clin Immunol 124 2009 292 300
13. A.M. Hofmann, A.M. Scurlock, S.M. Jones, K.P. Palmer, Y. Lokhnygina, P.H. Steele, and et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy J Allergy Clin Immunol 124 2009 286 291 e281-6
14. P. Varshney, P.H. Steele, B.P. Vickery, J.A. Bird, A. Thyagarajan, A.M. Scurlock, and et al. Adverse reactions during peanut oral immunotherapy home dosing J Allergy Clin Immunol 124 2009 1351 1352
15. K. Blumchen, H. Ulbricht, U. Staden, K. Dobberstein, J. Beschorner, L.C. de Oliveira, and et al. Oral peanut immunotherapy in children with peanut anaphylaxis J Allergy Clin Immunol 126 2010 83 91
16. E.H. Kim, J.A. Bird, M. Kulis, S. Laubach, L. Pons, W. Shreffler, and et al. Sublingual immunotherapy for peanut allergy: clinical and immunological evidence of desensitization J Allergy Clin Immunol 127 2011 640 646.e1
17. D.M. Fleischer, A.W. Burks, B.P. Vickery, A.M. Scurlock, R.A. Wood, S.M. Jones, and et al. Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial J Allergy Clin Immunol 131 2013 119 127.e7
18. M. Gorelik, S.D. Narisety, A.L. Guerrerio, K. Chichester, C.A. Keet, A.P. Bieneman, and et al. Suppression of the immunologic response to peanut during immunotherapy is often transient J Allergy Clin Immunol 135 2015 1283 1292
19. C.A. Keet, P.A. Frischmeyer-Guerrerio, A. Thyagarajan, J.T. Schroeder, R.G. Hamilton, S. Boden, and et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy J Allergy Clin Immunol 129 2012 448 455 e1-5
20. S.J. Chin, B.P. Vickery, M.D. Kulis, E.H. Kim, P. Varshney, P. Steele, and et al. Sublingual versus oral immunotherapy for peanut-allergic children: a retrospective comparison J Allergy Clin Immunol 132 2013 476 478
21. A.W. Burks, S.M. Jones, R.A. Wood, D.M. Fleischer, S.H. Sicherer, R.W. Lindblad, and et al. Oral immunotherapy for treatment of egg allergy in children N Engl J Med 367 2012 233 243
22. B.P. Vickery, A.M. Scurlock, M. Kulis, P.H. Steele, J. Kamilaris, J.P. Berglund, and et al. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy J Allergy Clin Immunol 133 2014 468 475