Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes

Cellular and Molecular Immunology

Volumn 13, Issue 6, 2016, Pages 805-815

  Ochel, Aaron ^a,d   Cebula, Marcin ^a   Riehn, Mathias ^a   Hillebrand, Upneet ^a   Lipps, Christoph ^a   Schirmbeck, Reinhold ^b   Hauser, Hansjörg ^a   Wirth, Dagmar ^a,c  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Antigen load; Chronicity; Immune modulation; T cell exhaustion

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; OVALBUMIN; TUMOR NECROSIS FACTOR; ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL FATE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION REGULATION; IMMUNOMODULATION; LIVER CELL; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE; UPREGULATION; ACUTE DISEASE; ANIMAL; C57BL MOUSE; HEPATITIS; IMMUNOLOGY; LIVER; LYMPHOCYTE ACTIVATION; PATHOLOGY;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; HEPATITIS; HEPATOCYTES; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE, INBRED C57BL;

EID: 84994582567     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2015.80     Document Type: Article

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