Antigen amount dictates CD8+ T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell

European Journal of Immunology

Volumn 42, Issue 9, 2012, Pages 2290-2304

  Richter, Kirsten ^a   Brocker, Thomas ^b   Oxenius, Annette ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antigen amount; CD8+ T cell; Chronic viral infection; Dysfunction; Immunopathology

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CELL STRESS; CELLULAR IMMUNITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; DENDRITIC CELL; HEMATOPOIETIC CELL; IMMUNOPATHOLOGY; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS LOAD;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; DENDRITIC CELLS; GENES, MHC CLASS I; IMMUNOTHERAPY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; VIRAL LOAD;

EID: 84865781144     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142275     Document Type: Article

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