Local intrahepatic CD8+ T cell activation by a non-self-antigen results in full functional differentiation

Journal of Immunology

Volumn 177, Issue 3, 2006, Pages 1689-1697

  Wuensch, Sherry A ^a   Pierce, Robert H ^a   Crispe, I Nicholas ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; LIVER ANTIGEN; PARVOVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CD8+ T LYMPHOCYTE; CLONE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HEPATITIS C; IMMUNE RESPONSE; IMMUNITY; IMMUNOLOGICAL TOLERANCE; INTERFERON PRODUCTION; LIVER CELL; LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 33746190823     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.3.1689     Document Type: Article

References (58)

1. Jenkins, M. K., A. Khoruts, E. Ingulli, D. L. Mueller, S. J. McSorley, R. L. Reinhardt, A. Itano, and K. A. Pape. 2001. In vivo activation of antigen-specific CD4 T cells. Annu. Rev. Immunol. 19: 23-45.
2. Burgio, V. L., G. Ballardini, M. Artini, M. Caratozzolo, F. B. Bianchi, and M. Levrero. 1998. Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology. Hepatology 27: 1600-1606.
3. Leifeld, L., C. Trautwein, F. L. Dumoulin, M, P. Manns, T. Sauerbruch, and U. Spengler. 1999. Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure. Am. J. Pathol 154: 1711-1720.
4. MacPhee, P. J., E. E. Schmidt, and A. C. Groom. 1992. Evidence for Kupffer cell migration along liver sinusoids, from high-resolution in vivo microscopy. Am. J. Physiol. 263: G17-G23.
5. Crofton, R. W., M. M. Diesselhoff-den Dulk, and R. van Furth. 1978. The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state. J. Exp. Med. 148: 1-17.
6. + T lymphocytes but fail to promote survival. Eur. J. Immunol. 28: 221-236.
7. Ando, K., T. Moriyama, L. G. Guidotti, S. Wirth, R. D. Schreiber, H. J. Schlicht, S. N. Huang, and F. V. Chisari. 1993. Mechanisms of class 1 restricted immunopathology: a transgenic mouse model of fulminant hepatitis. J. Exp. Med. 178: 1541-1554.
8. + T cell proliferation requires phosphatidylinositol 3-kinase activity. J. Immunol 166: 6523-6529.
9. Van Seventer, G. A., Y. Shimizu, K. J. Horgan, and S. Shaw. 1990. The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J. Immunol. 144: 4579-4586.
10. + T cells are poorly costimulated by ICAM-1. Eur. J. Immunol. 29: 45-53.
11. Qian, S., L. Lu, F. Fu, Y. Li, W. Li, T. E. Starzl, and J. J. Fung. 1997. Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J. Immunol. 158: 4654-4661.
12. Bertolino, P., M. C. Trescol-Biemont, J. Thomas, B. F. de St. Groth, M. Pihlgren, J. Marvel, and C. Rabourdin-Combe. 1999. Death by neglect as a deletional mechanism of peripheral tolerance. Int. Immunol. 11: 1225-1238.
13. Bowen, D. G., M. Zen, L. Holz, T. Davis, G. W. McCaughan, and P. Bertolino. 2004. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. J. Clin. Invest. 114: 701-712.
14. + T cells: CD4-independent help. J. Immunol 167: 1283-1289.
15. Clark, K. R., X. Liu, J. P. McGrath, and P. R. Johnson. 1999. Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum. Gene Ther. 10: 1031-1039.
16. Crispe, I. N., and W. Z. Mehal. 1996. Strange brew: T cells in the liver. Immunol. Today 17: 522-525.
17. -TCR αβ intermediate T cells in the liver of normal adult mice: implication for lpr pathogenesis. Int. Immunol. 6: 533-540.
18. Guengerich, F. P. 1979. Isolation and purification of cytochrome P-450, and the existence of multiple forms. Pharmacol. Ther. 6: 99-121.
19. Guzelian, P. S., D. M. Bissell, and U. A. Meyer. 1977. Drug metabolism in adult rat hepatocytes in primary monolayer culture. Gastroenterology 72: 1232-1239.
20. Michalopoulos, G., C. A. Sattler, G. L. Sattler, and H. C. Pilot. 1976. Cytochrome. P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes. Science 193: 907-909.
21. Rojkind, M., Z. Gatmaitan, S. Mackensen, M. A. Giambrone, P. Pohce, and L. M. Reid. 1980. Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes. J. Cell Biol. 87: 255-263.
22. Nakai, H., Y. Iwaki, M. A. Kay, and L. B. Couto. 1999. Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver. J. Virol. 73: 5438-5447.
23. Auphan-Anezin, N., G. Verdeil, and A. M. Schmitt-Verhulst. 2003. Distinct thresholds for CD8 T cell activation lead to functional heterogeneity: CD8 T cell priming can occur independently of cell division. J. Immunol 170: 2442-2448.
24. Gascoigne, N. R. J., and I. N. Crispe. 1984. Differential expression of the repertoire in in vivo and in vitro responses to minor alloantigens. Immunogenetics 19: 511-517.
25. Alam, S. M., I. N. Crispe, and N. R. Gascoigne. 1995. Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation. Immunity 3: 449-458.
26. Zaiss, A. K., Q. Liu, G. P. Bowen, N. C. Wong, J. S. Bartlett, and D. A. Muruve. 2002. Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors. J. Virol. 76: 4580-4590.
27. Greelish, J. P., L. T. Su, E. B. Lankford, J. M. Burkman, H. Chen, S. K. Konig, I. M. Mercier, P. R. Desjardins, M. A. Mitchell, X. G. Zheng, et al. 1999. Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector. Nat. Med. 5: 439-443.
28. Herzog, R. W., E. Y. Yang, L. B. Couto, J. N. Hagstrom, D. Elwell, P. A. Fields, M. Burton, D. A. Bellinger, M. S. Read, K. M. Brinkhous, et al. 1999. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nat. Med. 5: 56-63.
29. Bessis, N., F. J. GarciaCozar, and M. C. Boissier. 2004. Immune responses to gene therapy vectors: influence on vector function and effector mechanisms. Gene Ther. 11(Suppl. 1): S10-S17.
30. Herzog, R. W., J. N. Hagstrom, S. H. Kung, S. J. Tai, J. M. Wilson, K. J. Fisher, and K. A. High. 1997. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc. Natl. Acad. Sci. USA 94: 5804-5809.
31. Kay, M. A., C. S. Manno, M. V. Ragni, P. J. Larson, L. B. Couto, A. McClelland, B. Glader, A. J. Chew, S. J. Tai, R. W. Herzog, et al. 2000. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat. Genet. 24: 257-261.
32. Miao, C. H., H. Nakai, A. R. Thompson, T. A. Storm, W. Chiu, R. O. Snyder, and M. A. Kay. 2000. Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell-cycling does not influence hepatocyte transduction. J. Virol. 74: 3793-3803.
33. Nakai, H., C. E. Thomas, T. A. Storm, S. Fuess, S. Powell, J. F. Wright, and M. A. Kay. 2002. A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction. J. Virol. 76: 11343-11349.
34. Chen, S. J., J. Tazelaar, and J. M. Wilson. 2001. Selective repopulation of normal mouse liver by hepatocytes transduced in vivo with recombinant adeno-associated virus. Hum. Gene Ther. 12: 45-50.
35. Song, S., J. Embury, P. J. Laipis, K. I. Berns, J. M. Crawford, and T. R. Flotte. 2001. Stable therapeutic serum levels of human α-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Ther. 8: 1299-1306.
36. + T cell responses in vivo. J. Immunol. 171: 6339-6343.
37. + T cell response. Nat. Rev. Immunol. 4: 595-602.
38. + T lymphocytes. Nature 421: 852-856.
39. Keene, J. A., and J. Forman. 1982. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J. Exp. Med. 155: 768-782.
40. + cells after a transient response to antigen. Eur. J. Immunol. 23: 1963-1967.
41. + T cell help. J. Exp. Med. 186: 65-70.
42. Jennings, S. R., R. H. Bonneau, P. M. Smith, R. M. Wolcott, and R. Chervenak. 1991. CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 mice. Cell. Immunol. 133: 234-252.
43. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300: 339-342.
44. + T cell memory. Science 297: 2060-2063.
45. Mintern, J. D., G. M. Davey, G. T. Belz, F. R. Carbone, and W. R. Heath. 2002. Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells. J. Immunol. 168: 977-980.
46. + T cells activated locally within the transplanted liver. J. Exp. Med. 203: 437-447.
47. Brockstedt, D. G., G. M. Podsakoff, L. Fong, G. Kurtzman, W. Mueller-Ruchholtz, and E. G. Engleman. 1999. Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administration. Clin. Immunol. 92: 67-75.
48. Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401.
49. Palmer, E. 2003. Negative selection-clearing out the bad apples from the T cell repertoire. Nat. Rev. Immunol. 3: 383-391.
50. + T cells. Nat. Immunol. 6: 593-599.
51. Sun, Z., T. Wada, K. Maemura, K. Uchikura, S. Hoshino, A. M. Diehl, and A. S. Klein. 2003. Hepatic allograft-derived Kupffer cells regulate T cell response in rats. Liver Transpl. 9: 489-497.
52. Sato, K., K. Yabuki, T. Haba, and T. Maekawa. 1996. Role of Kupffer cells in the induction of tolerance after liver transplantation. J. Surg. Res. 63: 433-438.
53. Roland, C. R., M. J. Mangino, B. F. Duffy, and M. W. Flye. 1993. Lymphocyte suppression by Kupffer cells prevents portal venous tolerance induction: a study of macrophage function after intravenous gadolinium. Transplantation 55: 1151-1158.
54. Ishido, N., J. Matsuoka, T. Malsuno, K. Nakagawa, and N. Tanaka. 1999. Induction of donor-specific hyporesponsiveness and prolongation of cardiac allograft survival by jejunal administration of donor splenocytes. Transplantation 68: 1377-1382.
55. + T cells results in antigen-specific T cell tolerance. Nat. Med. 6: 1348-1354.
56. Knolle, P. A., and A. Limmer. 2001. Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells. Trends Immunol. 22: 432-437.
57. Katz, S. C., V. G. Pillarisetty, J. I. Bleier, A. B. Shah, and R. P. DeMatteo. 2004. Liver sinusoidal endothelial cells are insufficient to activate T cells. J. Immunol. 173: 230-235.
58. + T cell responses. J. Immunol. 174: 3401-3407.