Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Derkow, Katja ^a   Müller, Anja ^a   Eickmeier, Ira ^a   Seidel, Daniel ^a   Moreira, Marcos Vicinius ^a   Kruse, Nils ^a   Klugewitz, Katja ^a   Mintern, Justine ^b   Wiedenmann, Bertram ^a   Schott, Eckart ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LIVER ANTIGEN; OVALBUMIN; ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; DISEASE SEVERITY; HEPATITIS; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER INJURY; LYMPH NODE; MOUSE; NONHUMAN; SPLEEN; T LYMPHOCYTE ACTIVATION; TH1 CELL; ANIMAL; CYTOLOGY; FEMALE; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM;

MUS;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; MICE;

EID: 79960290721     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021847     Document Type: Article

References (38)

1. Shedlock DJ, Shen H, (2003) Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339.
2. Sun JC, Bevan MJ, (2003) Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300: 339-342.
3. Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687.
4. Grakoui A, Shoukry NH, Woollard DJ, Han JH, Hanson HL, et al. (2003) HCV persistence and immune evasion in the absence of memory T cell help. Science 302: 659-662.
5. Crispe IN, (2003) Hepatic T cells and liver tolerance. Nat Rev Immunol 3: 51-62.
6. O'Connell PJ, Morelli AE, Logar AJ, Thomson AW, (2000) Phenotypic and functional characterization of mouse hepatic CD8 alpha+ lymphoid-related dendritic cells. J Immunol 165: 795-803.
7. Rogoff TM, Lipsky PE, (1980) Antigen presentation by isolated guinea pig Kupffer cells. J Immunol 124: 1740-1744.
8. Limmer A, Ohl J, Kurts C, Ljunggren HG, Reiss Y, et al. (2000) Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med 6: 1348-1354.
9. Bertolino P, Bowen DG, McCaughan GW, Fazekas de St Groth B, (2001) Antigen-specific primary activation of CD8+ T cells within the liver. J Immunol 166: 5430-5438.
10. Matsuno K, Ezaki T, Kudo S, Uehara Y, (1996) A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph. J Exp Med 183: 1865-1878.
11. Bevan MJ, (1976) Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med 143: 1283-1288.
12. Wuensch SA, Pierce RH, Crispe IN, (2006) Local intrahepatic CD8+ T cell activation by a non-self-antigen results in full functional differentiation. J Immunol 177: 1689-1697.
13. Derkow K, Loddenkemper C, Mintern J, Kruse N, Klugewitz K, et al. (2007) Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis. Hepatology 46: 1155-1165.
14. Buxbaum J, Qian P, Allen PM, Peters MG, (2008) Hepatitis resulting from liver-specific expression and recognition of self-antigen. J Autoimmun 31: 208-215.
15. Zierden M, Kuhnen E, Odenthal M, Dienes HP, (2010) Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis. Gastroenterology 139: 975-986, 986 e971-973.
16. Herkel J, Jagemann B, Wiegard C, Lazaro JF, Lueth S, et al. (2003) MHC class II-expressing hepatocytes function as antigen-presenting cells and activate specific CD4 T lymphocyutes. Hepatology 37: 1079-1085.
17. Wiegard C, Wolint P, Frenzel C, Cheruti U, Schmitt E, et al. (2007) Defective T helper response of hepatocyte-stimulated CD4 T cells impairs antiviral CD8 response and viral clearance. Gastroenterology 133: 2010-2018.
18. Knolle PA, Schmitt E, Jin S, Germann T, Duchmann R, et al. (1999) Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells. Gastroenterology 116: 1428-1440.
19. Katz SC, Pillarisetty VG, Bleier JI, Shah AB, DeMatteo RP, (2004) Liver sinusoidal endothelial cells are insufficient to activate T cells. J Immunol 173: 230-235.
20. Elvevold K, Smedsrod B, Martinez I, (2008) The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity. Am J Physiol Gastrointest Liver Physiol 294: G391-400.
21. Onoe T, Ohdan H, Tokita D, Shishida M, Tanaka Y, et al. (2005) Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. J Immunol 175: 139-146.
22. Kruse N, Neumann K, Schrage A, Derkow K, Schott E, et al. (2009) Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3- regulatory T cells suppressing autoimmune hepatitis. Hepatology 50: 1904-1913.
23. Khanna A, Morelli AE, Zhong C, Takayama T, Lu L, et al. (2000) Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo. J Immunol 164: 1346-1354.
24. Klugewitz K, Topp SA, Dahmen U, Kaiser T, Sommer S, et al. (2002) Differentiation-dependent and subset-specific recruitment of T-helper cells into murine liver. Hepatology 35: 568-578.
25. Limmer A, Sacher T, Alferink J, Kretschmar M, Schonrich G, et al. (1998) Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment. Eur J Immunol 28: 2395-2406.
26. Bertolino P, Heath WR, Hardy CL, Morahan G, Miller JF, (1995) Peripheral deletion of autoreactive CD8+ T cells in transgenic mice expressing H-2Kb in the liver. Eur J Immunol 25: 1932-1942.
27. Wuensch SA, Spahn J, Crispe IN, (2010) Direct, help-independent priming of CD8+ T cells by adeno-associated virus-transduced hepatocytes. Hepatology 52: 1068-1077.
28. Crispe IN, (2011) Liver antigen-presenting cells. J Hepatol 54: 357-365.
29. Luth S, Huber S, Schramm C, Buch T, Zander S, et al. (2008) Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. J Clin Invest 118: 3403-3410.
30. Lohr HF, Schlaak JF, Gerken G, Fleischer B, Dienes HP, et al. (1994) Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology. Liver 14: 161-166.
31. Schlaak JF, Lohr H, Gallati H, Meyer zum Buschenfelde KH, Fleischer B, (1993) Analysis of the in vitro cytokine production by liver-infiltrating T cells of patients with autoimmune hepatitis. Clin Exp Immunol 94: 168-173.
32. Senaldi G, Portmann B, Mowat AP, Mieli-Vergani G, Vergani D, (1992) Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis. Arch Dis Child 67: 1447-1453.
33. Ichiki Y, Aoki CA, Bowlus CL, Shimoda S, Ishibashi H, et al. (2005) T cell immunity in autoimmune hepatitis. Autoimmun Rev 4: 315-321.
34. Suzuki Y, Kobayashi M, Hosaka T, Someya T, Akuta N, et al. (2004) Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis. J Gastroenterol 39: 649-653.
35. Sprengers D, Sille FC, Derkow K, Besra GS, Janssen HL, et al. (2008) Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen. Gastroenterology 134: 2132-2143.
36. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
37. Barnden MJ, Allison J, Heath WR, Carbone FR, (1998) Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76: 34-40.
38. Mintern J, Li M, Davey GM, Blanas E, Kurts C, et al. (1999) The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo. Immunol Cell Biol 77: 539-543.