A demonstration of the uncertainty in predicting the estrogenic activity of individual chemicals and mixtures from an in vitro estrogen receptor transcriptional activation assay (T47D-KBluc) to the in vivo uterotrophic assay using oral exposure

Toxicological Sciences

Volumn 153, Issue 2, 2016, Pages 382-395

  Conley, Justin M ^a   Hannas, Bethany R ^a,b   Furr, Johnathan R ^a,c   Wilson, Vickie S ^a   Gray, L Earl ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

bisphenols; Estrogen; Mixture; Oral exposure; T47D KBluc; Uterotrophic

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BISPHENOL AF; BISPHENOL C; BISPHENOL S; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTRADIOL BENZOATE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ETHINYLESTRADIOL; METHOXYCHLOR; PHTHALIC ACID BENZYL BUTYL ESTER; UNCLASSIFIED DRUG; ESTROGEN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG EXPOSURE; DRUG METABOLISM; DRUG POTENCY; EC50; ESTROGEN ACTIVITY; FACTOR ANALYSIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OVARIECTOMY; PHARMACOKINETIC PARAMETERS; PREDICTION; RAT; RELATIVE POTENCY FACTOR; SINGLE DRUG DOSE; TOXICOKINETICS; TRANSACTIVATION ASSAY; TRANSCRIPTION INITIATION; UNCERTAINTY; UTEROTROPHIC ASSAY; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; SPRAGUE DAWLEY RAT; UTERUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; TRANSCRIPTIONAL ACTIVATION; UNCERTAINTY; UTERUS;

EID: 84994525150     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw134     Document Type: Article

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