Extensive metabolism and route-dependent pharmacokinetics of bisphenol A (BPA) in neonatal mice following oral or subcutaneous administration

Toxicology

Volumn 333, Issue , 2015, Pages 168-178

  Draganov, Dragomir I ^a   Markham, Dan A ^b   Beyer, Dieter ^c   Waechter, John M ^b   Dimond, Stephen S ^d   Budinsky, Robert A ^b   Shiotsuka, Ronald N ^e   Snyder, Stephanie A ^e   Ehman, Kimberly D ^f   Hentges, Steven G ^g  

^a WIL RESEARCH LABORATORIES   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c BAYER PHARMA AG   (Germany)

^d SABIC INNOVATIVE PLASTICS   (United States)

^e Formerly Baver Material Science AG   (United States)

^f Toxicology/Regulatory Services Inc   (United States)

^g AMERICAN CHEMISTRY COUNCIL   (United States)

Author keywords

Bisphenol A; CAS No. 80 05 7; Mice; Neonates; Pharmacokinetics; Route dependent

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BENZHYDRYL DERIVATIVE; BISPHENOL A GLUCURONIDE; GLUCURONIDE; PHENOL DERIVATIVE; SULFATE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID SCINTILLATION COUNTING; MAXIMUM PLASMA CONCENTRATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RADIOCHROMATOGRAPHY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOTRANSFORMATION; BLOOD; COMPARATIVE STUDY; METABOLOMICS; ORAL DRUG ADMINISTRATION; PROCEDURES; SUBCUTANEOUS DRUG ADMINISTRATION; TANDEM MASS SPECTROMETRY;

MUS;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; BENZHYDRYL COMPOUNDS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUCURONIDES; INJECTIONS, SUBCUTANEOUS; METABOLOMICS; MICE; PHENOLS; SULFATES; TANDEM MASS SPECTROMETRY;

EID: 84929660171     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2015.04.012     Document Type: Article

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