A murine model of type 2 diabetes mellitus developed using a combination of high fat diet and multiple low doses of streptozotocin treatment mimics the metabolic characteristics of type 2 diabetes mellitus in humans

Journal of Pharmacological and Toxicological Methods

Volumn 84, Issue , 2017, Pages 20-30

  Nath, Sayantan ^a   Ghosh, Sankar Kumar ^a   Choudhury, Yashmin ^a  

^a ASSAM UNIVERSITY   (India)

Author keywords

High fat diet; Metformin; Streptozotocin; Type 2 diabetes mellitus; Vildagliptin

Indexed keywords

CATALASE; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; STREPTOZOCIN; TRIACYLGLYCEROL; VILDAGLIPTIN; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE BLOOD LEVEL;

AGE DISTRIBUTION; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES CONTROL; DIET RESTRICTION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HEART; HUMAN; INSULIN SENSITIVITY; KIDNEY; LIPID ANALYSIS; LIPID DIET; LIPID PEROXIDATION; LIVER; MALE; METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PROTEIN CARBONYLATION; SERUM; SEX DIFFERENCE; TISSUE LEVEL; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; ADVERSE EFFECTS; ANIMAL; BLOOD; CHEMICALLY INDUCED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE MODEL; DRUG EFFECTS;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; STREPTOZOCIN;

EID: 84994383142     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2016.10.007     Document Type: Article

References (49)

1. Aebi, H., Catalase in vitro. Methods in Enzymology 105 (1984), 121–126.
2. Akarte, A.S., Srinivasan, B.P., Gandhi, S., Vildagliptin selectively ameliorates GLP-1, GLUT4, SREBP-1c mRNA levels and stimulates beta-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes. Journal of Diabetes and its Complications 26:4 (2012), 266–274.
3. Algire, C., Zakikhani, M., Blouin, M.J., Shuai, J.H., Pollak, M., Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocrine-Related Cancer 15:3 (2008), 833–839.
4. Allison, D.B., Paultre, F., Maggio, C., Mezzitis, N., Pi-Sunyer, F.X., The use of areas under curves in diabetes research. Diabetes Care 18:2 (1995), 245–250 (Research Support, Non-U.S. Gov't).
5. Aragno, M., Brignardello, E., Tamagno, E., Gatto, V., Danni, O., Boccuzzi, G., Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. The Journal of Endocrinology 155:2 (1997), 233–240.
6. Arulmozhi, D.K., Kurian, R., Bodhankar, S.L., Veeranjaneyulu, A., Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes. The Journal of Pharmacy and Pharmacology 60:9 (2008), 1167–1173.
7. Bonomi, L., Brown, M., Ungerleider, N., Muse, M., Matzuk, M.M., Schneyer, A., Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity. American Journal of Physiology. Endocrinology and Metabolism 303 (2012), E587–E596.
8. Cade, W.T., Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Physical Therapy 88:11 (2008), 1322–1335.
9. Chen, D., Wang, M.W., Development and application of rodent models for type 2 diabetes. Diabetes, Obesity & Metabolism 7:4 (2005), 307–317.
10. Donath, M.Y., Schumann, D.M., Faulenbach, M., Ellingsgaard, H., Perren, A., Ehses, J.A., Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Diabetes Care 31:Suppl 2 (2008), S161–S164.
11. Doycheva, I., Patel, N., Peterson, M., Loomba, R., Prognostic implication of liver histology in patients with nonalcoholic fatty liver disease in diabetes. Journal of Diabetes and its Complications 27:3 (2013), 293–300.
12. Espinel, E., Agraz, I., Ibernon, M., Ramos, N., Fort, J., Serón, D., Renal biopsy in type 2 diabetic patients. Journal of Clinical Medicine 4:5 (2015), 998–1009.
13. Freeman, J.S., Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus. Cleveland Clinic Journal of Medicine 76:Suppl 5 (2009), S12–S19.
14. Hardie, D.G., Neither LKB1 nor AMPK are the direct targets of metformin. Gastroenterology, 131(3), 2006, 973 (author reply 974–975).
15. Hu, J., Pang, W., Chen, J., Bai, S., Zheng, Z., Wu, X., Hypoglycemic effect of polysaccharides with different molecular weight of Pseudostellaria heterophylla. BMC Complementary and Alternative Medicine, 13, 2013, 267.
16. Hugill, A.J., Stewart, M.E., Yon, M.A., Probert, F., Cox, I.J., Hough, T.A., Cox, R.D., Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance. Biology Open 4:11 (2015), 1367–1375.
17. Inzucchi, S.E., Bergenstal, R.M., Buse, J.B., Diamant, M., Ferrannini, E., Nauck, M., Matthews, D.R., Management of hyperglycaemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 55:6 (2012), 1577–1596.
18. Junker, A.E., Gluud, L.L., Pedersen, J., Langhoff, J.L., Holst, J.J., Knop, F.K., Vilsbøll, T., A 25-year-old woman with type 2 diabetes and liver disease. Case Reports in Gastroenterology 8:3 (2014), 398–403.
19. Kahn, S.E., Zraika, S., Utzschneider, K.M., Hull, R.L., The beta cell lesion in type 2 diabetes: There has to be a primary functional abnormality. Diabetologia 52:6 (2009), 1003–1012.
20. Kahn, S.E., Cooper, M.E., Del Prato, S., Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future. Lancet 383:9922 (2014), 1068–1083.
21. Kang, S.J., Lee, J.E., Lee, E.K., Jung, D.H., Song, C.H., Park, S.J., Lee, Y.J., Fermentation with Aquilariae Lignum enhances the anti-diabetic activity of green tea in type II diabetic db/db mouse. Nutrients 6:9 (2014), 3536–3571.
22. Kannan, Y., Tokunaga, M., Moriyama, M., Kinoshita, H., Nakamura, Y., Beneficial effects of troglitazone on neutrophil dysfunction in multiple low-dose streptozotocin-induced diabetic mice. Clinical and Experimental Immunology 137:2 (2004), 263–271.
23. Kieffer, T.J., Habener, J.F., The glucagon-like peptides. Endocrine Reviews 20:6 (1999), 876–913.
24. Kim, J.H., Saxton, A.M., The TALLYHO mouse as a model of human type 2 diabetes. Methods in Molecular Biology, 933, 2012, 7587.
25. Kunjathoor, V.V., Wilson, D.L., LeBoeuf, R.C., Increased atherosclerosis in streptozotocin-induced diabetic mice. The Journal of Clinical Investigation 97:7 (1996), 1767–1773.
26. Kusakabe, T., Tanioka, H., Ebihara, K., Hirata, M., Miyamoto, L., Miyanaga, F., Nakao, K., Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet. Diabetologia 52:4 (2009), 675–683 (Research Support, Non-U.S. Gov't).
27. Levine, R.L., Garland, D., Oliver, C.N., Amici, A., Climent, I., Lenz, A.G., Stadtman, E.R., Determination of carbonyl content in oxidatively modified proteins. Methods in Enzymology 186 (1990), 464–478.
28. Li, Y.G., Ji, D.F., Zhong, S., Lin, T.B., Lv, Z.Q., Hypoglycemic effect of deoxynojirimycin-polysaccharide on high fat diet and streptozotocin-induced diabetic mice via regulation of hepatic glucose metabolism. Chemico-Biological Interactions 225 (2015), 70–79.
29. Macotela, Y., Boucher, J., Tran, T.T., Kahn, C.R., Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism. Diabetes 58:4 (2009), 803–812.
30. Mathe, D., Dyslipidemia and diabetes: Animal models. Diabète & Métabolisme 21:2 (1995), 106–111.
31. McEvoy, R.C., Andersson, J., Sandler, S., Hellerstrom, C., Multiple low-dose streptozotocin-induced diabetes in the mouse. Evidence for stimulation of a cytotoxic cellular immune response against an insulin-producing beta cell line. The Journal of Clinical Investigation 74:3 (1984), 715–722.
32. Niehaus, W.G. Jr., Samuelsson, B., Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. European Journal of Biochemistry 6:1 (1968), 126–130.
33. Omabe, M., Nwudele, C., Omabe, K.N., Okorocha, A.E., Anion gap toxicity in alloxan induced type 2 diabetic rats treated with antidiabetic Noncytotoxic bioactive compounds of ethanolic extract of Moringa oleifera. Journal of Toxicology, 2014, 2014, 406242.
34. Ozcan, U., Cao, Q., Yilmaz, E., Lee, A.H., Iwakoshi, N.N., Ozdelen, E., Hotamisligil, G.S., Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:5695 (2004), 457–461.
35. Prieto, P., Vallejo-Cremades, M.T., Benito, G., González-Peramato, P., Francés, D., Agra, N., Fernández-Velasco, M., NOD1 receptor is up-regulated in diabetic human and murine myocardium. Clinical Science (London, England) 127:12 (2014), 665–677.
36. Reed, M.J., Meszaros, K., Entes, L.J., Claypool, M.D., Pinkett, J.G., Gadbois, T.M., Reaven, G.M., A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat. Metabolism 49:11 (2000), 1390–1394.
37. Ryden, L., Grant, P.J., Anker, S.D., Berne, C., Cosentino, F., Danchin, N., Xuereb, R.G., ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). European Heart Journal 34:39 (2013), 3035–3087.
38. Schubert, G.E., Adam, A., Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma. Journal of Clinical Pathology 27:10 (1974), 800–805.
39. Shaw, R.J., Lamia, K.A., Vasquez, D., Koo, S.H., Bardeesy, N., Depinho, R.A., Cantley, L.C., The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310:5754 (2005), 1642–1646.
40. Shinde, S.N., Dhadke, V.N., Suryakar, A.N., Evaluation of oxidative stress in type 2 diabetes mellitus and follow-up along with vitamin E supplementation. Indian Journal of Clinical Biochemistry 26:1 (2011), 74–77.
41. Srinivasan, K., Viswanad, B., Asrat, L., Kaul, C.L., Ramarao, P., Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening. Pharmacological Research 52:4 (2005), 313–320.
42. Szkudelski, T., The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiological Research 50:6 (2001), 537–546.
43. Takeda, Y., Fujita, Y., Honjo, J., Yanagimachi, T., Sakagami, H., Takiyama, Y., Haneda, M., Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. Diabetologia 55:2 (2012), 404–412.
44. Tangvarasittichai, S., Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World Journal of Diabetes 6:3 (2015), 456–480.
45. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Tepper, R.I., Identification and expression cloning of a leptin receptor, OB-R. Cell 83:7 (1995), 1263–1271.
46. Tiwari, B.K., Pandey, K.B., Abidi, A.B., Rizvi, S.I., Markers of oxidative stress during diabetes mellitus. Journal of Biomarkers, 2013, 2013, 378790.
47. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., Friedman, J.M., Positional cloning of the mouse obese gene and its human homologue. Nature 372:6505 (1994), 425–432.
48. Zhang, M., Lv, X.Y., Li, J., Xu, Z.G., Chen, L., The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Experimental Diabetes Research 2008:704045 (2008), 1–9.
49. Zucker, L.M., Hereditary obesity in the rat associated with hyperlipemia. Annals of the New York Academy of Sciences 131:1 (1965), 447–458.