Structural elements of an NRPS cyclization domain and its intermodule docking domain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 44, 2016, Pages 12432-12437

  Dowling, Daniel P ^a,e   Kung, Yan ^a,f   Croft, Anna K ^b   Taghizadeh, Koli ^c,g   Kelly, Wendy L ^d   Walsh, Christopher T ^d   Drennan, Catherine L ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^f BRYN MAWR COLLEGE   (United States)

^g GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Crystal structure; Epothilone; Molecular dynamics; Natural product

Indexed keywords

BACTERIAL PROTEIN; CARRIER PROTEIN; EPOB PROTEIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; EPOTHILONE DERIVATIVE; PEPTIDE SYNTHASE; PROTEIN BINDING; THIAZOLE DERIVATIVE;

CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME ACTIVE SITE; HYBRID; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR SIZE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SORANGIUM CELLULOSUM; AMINO ACID SEQUENCE; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR MODEL; MYXOCOCCALES; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; EPOTHILONES; MODELS, MOLECULAR; MYXOCOCCALES; PEPTIDE SYNTHASES; POLYKETIDE SYNTHASES; PROTEIN BINDING; PROTEIN DOMAINS; SEQUENCE HOMOLOGY, AMINO ACID; THIAZOLES;

EID: 84994360407     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1608615113     Document Type: Article

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