Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases

Journal of Molecular Biology

Volumn 425, Issue 17, 2013, Pages 3137-3150

  Bloudoff, Kristjan ^a   Rodionov, Dmitry ^a   Schmeing, T Martin ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

calcium dependent antibiotic; condensation domain; conformational changes; nonribosomal peptide synthetases; X ray crystallography

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM DEPENDENT ANTIBIOTIC SYNTHETASE; NONRIBOSOMAL PEPTIDE SYNTHETASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; ENZYME SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES COELICOLOR; X RAY CRYSTALLOGRAPHY;

STREPTOMYCES COELICOLOR;

EID: 84881664990     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.06.003     Document Type: Article

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