Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Nature

Volumn 529, Issue 7585, 2016, Pages 235-238

  Drake, Eric J ^a,b   Miller, Bradley R ^a,b   Shi, Ce ^c   Tarrasch, Jeffrey T ^d   Sundlov, Jesse A ^a,b   Leigh Allen, C ^a   Skiniotis, Georgios ^d   Aldrich, Courtney C ^c   Gulick, Andrew M ^a,b  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; NONRIBOSOMAL PEPTIDE SYNTHETASE; PANTETHEINE PHOSPHATE; THIOL ESTER HYDROLASE; 2,3-DIHYDROXYBENZOATE - SERINE LIGASE; 4'-PHOSPHOPANTETHEINE; CARRIER PROTEIN; COENZYME; HOLOENZYME; PANTETHEINE; PEPTIDE SYNTHASE;

AMINO ACID; BIOENGINEERING; CATALYSIS; ELECTRON MICROSCOPY; PEPTIDE; PROTEIN;

ADENYLATION; ARTICLE; CONFORMATIONAL TRANSITION; ELECTRON MICROSCOPY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME ENGINEERING; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; POLYMERIZATION; PRIORITY JOURNAL; SINGLE PARTICLE ELECTRON MICROSCOPY; ACINETOBACTER BAUMANNII; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMISTRY; COENZYME; ENZYMOLOGY; ESCHERICHIA COLI; METABOLISM; MOLECULAR MODEL; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACINETOBACTER BAUMANNII; BIOCATALYSIS; CARRIER PROTEINS; COENZYMES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HOLOENZYMES; MODELS, MOLECULAR; PANTETHEINE; PEPTIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY;

EID: 84955119754     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16163     Document Type: Article

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