HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy

Oncotarget

Volumn 7, Issue 40, 2016, Pages 64820-64835

  Mehta, Meghna ^a   Basalingappa, Kanthesh ^a   Griffith, James N ^a   Andrade, Daniel ^a   Babu, Anish ^a,b   Amreddy, Narsireddy ^a,b   Muralidharan, Ranganayaki ^a,b   Gorospe, Myriam ^c   Herman, Terence ^a   Ding, Wei Qun ^a   Ramesh, Rajagopal ^a,b   Munshi, Anupama ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Breast cancer; DNA repair; HuR; Oxidative stress; Radiation; SiRNA

Indexed keywords

ACETYLCYSTEINE; ELAV LIKE PROTEIN 1; HISTONE H2AX; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; THIOREDOXIN REDUCTASE; THIOREDOXIN REDUCTASE 1; ELAVL1 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER CELL LINE; BREAST EPITHELIUM CELL; CANCER CELL; CANCER RADIOTHERAPY; CELL SURVIVAL; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HS578T CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; MDA MB 231 CELL LINE; MDA MB 468 CELL LINE; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RADIOSENSITIZATION; TRIPLE NEGATIVE BREAST CANCER; WESTERN BLOTTING; ADENOCARCINOMA; APOPTOSIS; FEMALE; GENETICS; METABOLISM; RADIATION TOLERANCE; TUMOR CELL LINE;

ADENOCARCINOMA; APOPTOSIS; CELL LINE, TUMOR; COMET ASSAY; DNA DAMAGE; ELAV-LIKE PROTEIN 1; FEMALE; HUMANS; OXIDATIVE STRESS; RADIATION TOLERANCE; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; THIOREDOXIN-DISULFIDE REDUCTASE; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84994172683     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.11706     Document Type: Article

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