메뉴 건너뛰기




Volumn 26, Issue 1, 2011, Pages 237-245

Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9

Author keywords

Breast cancer; Cyclin D1; Growth; Human antigen R; Invasion; MMP 9

Indexed keywords

CYCLIN D1; GELATINASE B; HU ANTIGEN; HUMAN ANTIGEN R; MESSENGER RNA; RIBOZYME; UNCLASSIFIED DRUG;

EID: 79955854286     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1271     Document Type: Article
Times cited : (29)

References (36)
  • 1
    • 0029873536 scopus 로고    scopus 로고
    • Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
    • DOI 10.1074/jbc.271.14.8144
    • Ma WJ, Cheng S, Campbell C, Wright A and Furneaux H: Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem 271: 8144-8151, 1996. (Pubitemid 26108641)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.14 , pp. 8144-8151
    • Ma, W.-J.1    Cheng, S.2    Campbell, C.3    Wright, A.4    Furneaux, H.5
  • 2
    • 0031060705 scopus 로고    scopus 로고
    • Localization of the human HuR gene to chromosome 19p13.2
    • Ma WJ and Furneaux H: Localization of the human HuR gene to chromosome 19p13.2. Hum Genet 99: 32-33, 1997.
    • (1997) Hum Genet , vol.99 , pp. 32-33
    • Ma, W.J.1    Furneaux, H.2
  • 3
    • 0027309573 scopus 로고
    • Gene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans
    • DOI 10.1002/neu.480240604
    • Yao KM, Samson ML, Reeves R and White K: Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans. J Neurobiol 24: 723-739, 1993. (Pubitemid 23157139)
    • (1993) Journal of Neurobiology , vol.24 , Issue.6 , pp. 723-739
    • Yao, K.-M.1    Samson, M.-L.2    Reeves, R.3    White, K.4
  • 4
    • 0032526417 scopus 로고    scopus 로고
    • RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
    • DOI 10.1093/emboj/17.12.3461
    • Peng SS, Chen CY, Xu N and Shyu AB: RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 17: 3461-3470, 1998. (Pubitemid 28279518)
    • (1998) EMBO Journal , vol.17 , Issue.12 , pp. 3461-3470
    • Peng, S.S.-Y.1    Chen, C.-Y.A.2    Xu, N.3    Shyu, A.-B.4
  • 5
    • 0030909816 scopus 로고    scopus 로고
    • A hierarchy of Hu RNA binding proteins in developing and adult neurons
    • Okano HJ and Darnell RB: A hierarchy of Hu RNA binding proteins in developing and adult neurons. J Neurosci 17: 3024-3037, 1997.
    • (1997) J Neurosci , vol.17 , pp. 3024-3037
    • Okano, H.J.1    Darnell, R.B.2
  • 7
    • 0034655951 scopus 로고    scopus 로고
    • NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C
    • Inoue M, Muto Y, Sakamoto H and Yokoyama S: NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C. Nucleic Acids Res 28: 1743-1750, 2000. (Pubitemid 30199307)
    • (2000) Nucleic Acids Research , vol.28 , Issue.8 , pp. 1743-1750
    • Inoue, M.1    Muto, Y.2    Sakamoto, H.3    Yokoyama, S.4
  • 8
    • 0037008694 scopus 로고    scopus 로고
    • Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD
    • DOI 10.1074/jbc.M201982200
    • Beckel-Mitchener AC, Miera A, Keller R and Perrone-Bizzozero NI: Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD. J Biol Chem 277: 27996-28002, 2002. (Pubitemid 34966749)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.31 , pp. 27996-28002
    • Beckel-Mitchener, A.C.1    Miera, A.2    Keller, R.3    Perrone-Bizzozero, N.I.4
  • 9
    • 0030933006 scopus 로고    scopus 로고
    • Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay
    • DOI 10.1093/emboj/16.8.2130
    • Myer VE, Fan XC and Steitz JA: Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J 16: 2130-2139, 1997. (Pubitemid 27170973)
    • (1997) EMBO Journal , vol.16 , Issue.8 , pp. 2130-2139
    • Myer, V.E.1    Fan, X.C.2    Steitz, J.A.3
  • 10
    • 0037252788 scopus 로고    scopus 로고
    • ARED 2.0: An update of AU-rich element mRNA database
    • DOI 10.1093/nar/gkg023
    • Bakheet T, Williams BR and Khabar KS: ARED 2.0: an update of AU-rich element mRNA database. Nucleic Acids Res 31: 421-423, 2003. (Pubitemid 36150418)
    • (2003) Nucleic Acids Research , vol.31 , Issue.1 , pp. 421-423
    • Bakheet, T.1    Williams, B.R.G.2    Khabar, K.S.A.3
  • 11
    • 0030867877 scopus 로고    scopus 로고
    • Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression
    • Antic D and Keene JD: Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. Am J Hum Genet 61: 273-278, 1997. (Pubitemid 27382301)
    • (1997) American Journal of Human Genetics , vol.61 , Issue.2 , pp. 273-278
    • Antic, D.1    Keene, J.D.2
  • 12
    • 0032526427 scopus 로고    scopus 로고
    • Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs
    • DOI 10.1093/emboj/17.12.3448
    • Fan XC and Steitz JA: Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J 17: 3448-3460, 1998. (Pubitemid 28279517)
    • (1998) EMBO Journal , vol.17 , Issue.12 , pp. 3448-3460
    • Fan, X.C.1    Steitz, J.A.2
  • 13
    • 0042121256 scopus 로고    scopus 로고
    • Mfold web server for nucleic acid folding and hybridization prediction
    • Zuker M: Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31: 3406-3415, 2003.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3406-3415
    • Zuker, M.1
  • 14
    • 15444362203 scopus 로고    scopus 로고
    • Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection
    • DOI 10.1016/j.bbrc.2005.02.157
    • Jiang WG, Davies G and Fodstad O: Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection. Biochem Biophys Res Commun 330: 253-262, 2005. (Pubitemid 40394960)
    • (2005) Biochemical and Biophysical Research Communications , vol.330 , Issue.1 , pp. 253-262
    • Jiang, W.G.1    Davies, G.2    Fodstad, O.3
  • 16
    • 38449085987 scopus 로고    scopus 로고
    • Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro
    • Sanders AJ, Parr C, Mason MD and Jiang WG: Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro. Int J Mol Med 20: 613-619, 2007.
    • (2007) Int J Mol Med , vol.20 , pp. 613-619
    • Sanders, A.J.1    Parr, C.2    Mason, M.D.3    Jiang, W.G.4
  • 17
    • 0028824758 scopus 로고
    • Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA)
    • Jiang WG, Hiscox S, Hallett MB, Horrobin DF, Mansel RE and Puntis MC: Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). Cancer Res 55: 5043-5048, 1995.
    • (1995) Cancer Res , vol.55 , pp. 5043-5048
    • Jiang, W.G.1    Hiscox, S.2    Hallett, M.B.3    Horrobin, D.F.4    Mansel, R.E.5    Puntis, M.C.6
  • 18
    • 0028941798 scopus 로고
    • Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid
    • Jiang WG, Hiscox S, Hallett MB, Scott C, Horrobin DF and Puntis MC: Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. Br J Cancer 71: 744-752, 1995.
    • (1995) Br J Cancer , vol.71 , pp. 744-752
    • Jiang, W.G.1    Hiscox, S.2    Hallett, M.B.3    Scott, C.4    Horrobin, D.F.5    Puntis, M.C.6
  • 19
    • 0032713122 scopus 로고    scopus 로고
    • Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells
    • Jiang WG, Hiscox SE, Parr C, et al: Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells. Clin Cancer Res 5: 3695-3703, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 3695-3703
    • Jiang, W.G.1    Hiscox, S.E.2    Parr, C.3
  • 20
    • 67649352637 scopus 로고    scopus 로고
    • Nuclear cyclin D1: An oncogenic driver in human cancer
    • Kim JK and Diehl JA: Nuclear cyclin D1: an oncogenic driver in human cancer. J Cell Physiol 220: 292-296, 2009.
    • (2009) J Cell Physiol , vol.220 , pp. 292-296
    • Kim, J.K.1    Diehl, J.A.2
  • 21
    • 0035819050 scopus 로고    scopus 로고
    • Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells
    • DOI 10.1038/sj.onc.1204944
    • Yao J, Xiong S, Klos K, et al: Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene 20: 8066-8074, 2001. (Pubitemid 34028331)
    • (2001) Oncogene , vol.20 , Issue.56 , pp. 8066-8074
    • Yao, J.1    Xiong, S.2    Klos, K.3    Nguyen, N.4    Grijalva, R.5    Li, P.6    Yu, D.7
  • 22
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000. (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 23
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • DOI 10.1038/nm1087
    • Vogelstein B and Kinzler KW: Cancer genes and the pathways they control. Nat Med 10: 789-799, 2004. (Pubitemid 39070849)
    • (2004) Nature Medicine , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 24
    • 4143122397 scopus 로고    scopus 로고
    • Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
    • DOI 10.1038/sj.emboj.7600305
    • Lal A, Mazan-Mamczarz K, Kawai T, Yang X, Martindale JL and Gorospe M: Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J 23: 3092-3102, 2004. (Pubitemid 39093603)
    • (2004) EMBO Journal , vol.23 , Issue.15 , pp. 3092-3102
    • Lal, A.1    Mazan-Mamczarz, K.2    Kawai, T.3    Yang, X.4    Martindale, J.L.5    Gorospe, M.6
  • 25
    • 0034657686 scopus 로고    scopus 로고
    • HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation
    • Wang W, Caldwell MC, Lin S, Furneaux H and Gorospe M: HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 19: 2340-2350, 2000. (Pubitemid 30259015)
    • (2000) EMBO Journal , vol.19 , Issue.10 , pp. 2340-2350
    • Wang, W.1    Caldwell, M.C.2    Lin, S.3    Furneaux, H.4    Gorospe, M.5
  • 26
    • 0034908634 scopus 로고    scopus 로고
    • Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence
    • DOI 10.1128/MCB.21.17.5889-5898.2001
    • Wang W, Yang X, Cristofalo VJ, Holbrook NJ and Gorospe M: Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol Cell Biol 21: 5889-5898, 2001. (Pubitemid 32737806)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.17 , pp. 5889-5898
    • Wang, W.1    Yang, X.2    Cristofalo, V.J.3    Holbrook, N.J.4    Gorospe, M.5
  • 27
    • 6044269455 scopus 로고    scopus 로고
    • Androgens regulate the binding of endogenous HuR to the AU-rich 3′UTRs of HIF-1alpha and EGF mRNA
    • DOI 10.1016/j.bbrc.2004.07.173, PII S0006291X04016298
    • Sheflin LG, Zou AP and Spaulding SW Androgens regulate the binding of endogenous HuR to the AU-rich 3′UTRs of HIF-1alpha and EGF mRNA. Biochem Biophys Res Commun 322: 644-651, 2004. (Pubitemid 39490351)
    • (2004) Biochemical and Biophysical Research Communications , vol.322 , Issue.2 , pp. 644-651
    • Sheflin, L.G.1    Zou, A.-P.2    Spaulding, S.W.3
  • 28
    • 0346366983 scopus 로고    scopus 로고
    • Hyaluronic Acid or TNF-alpha Plus Fibronectin Triggers Granulocyte Macrophage-Colony-Stimulating Factor mRNA Stabilization in Eosinophils Yet Engages Differential Intracellular Pathways and mRNA Binding Proteins
    • Esnault S and Malter JS: Hyaluronic acid or TNF-alpha plus fibronectin triggers granulocyte macrophage-colony-stimulating factor mRNA stabilization in eosinophils yet engages differential intracellular pathways and mRNA binding proteins. J Immunol 171: 6780-6787, 2003. (Pubitemid 37532112)
    • (2003) Journal of Immunology , vol.171 , Issue.12 , pp. 6780-6787
    • Esnault, S.1    Malter, J.S.2
  • 29
    • 0032513043 scopus 로고    scopus 로고
    • Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
    • DOI 10.1074/jbc.273.11.6417
    • Levy NS, Chung S, Furneaux H and Levy AP: Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem 273: 6417-6423, 1998. (Pubitemid 28144735)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.11 , pp. 6417-6423
    • Levy, N.S.1    Chung, S.2    Furneaux, H.3    Levy, A.P.4
  • 30
    • 0141640857 scopus 로고    scopus 로고
    • Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
    • DOI 10.1128/MCB.23.20.7177-7188.2003
    • Tran H, Maurer F and Nagamine Y: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Mol Cell Biol 23: 7177-7188, 2003. (Pubitemid 37211000)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.20 , pp. 7177-7188
    • Tran, H.1    Maurer, F.2    Nagamine, Y.3
  • 32
    • 27744520451 scopus 로고    scopus 로고
    • HuR: Post-transcriptional paths to malignancy
    • Lopez de Silanes I, Lal A and Gorospe M: HuR: post-transcriptional paths to malignancy. RNA Biol 2: 11-13, 2005.
    • (2005) RNA Biol , vol.2 , pp. 11-13
    • Lopez De Silanes, I.1    Lal, A.2    Gorospe, M.3
  • 33
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr CJ: Mammalian G1 cyclins. Cell 73: 1059-1065, 1993.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 34
    • 0034780882 scopus 로고    scopus 로고
    • Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II
    • PII S0169500201002252
    • Jin M, Inoue S, Umemura T, et al: Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II. Lung Cancer 34: 207-218, 2001. (Pubitemid 33010796)
    • (2001) Lung Cancer , vol.34 , Issue.2 , pp. 207-218
    • Jin, M.1    Inoue, S.2    Umemura, T.3    Moriya, J.4    Arakawa, M.5    Nagashima, K.6    Kato, H.7
  • 36
    • 0034132687 scopus 로고    scopus 로고
    • Cyclin D1 overexpression in esophageal dysplasia: A possible biomarker for carcinogenesis of esophageal squamous cell carcinoma
    • Shamma A, Doki Y, Shiozaki H, et al: Cyclin D1 overexpression in esophageal dysplasia: a possible biomarker for carcinogenesis of esophageal squamous cell carcinoma. Int J Oncol 16: 261-266, 2000.
    • (2000) Int J Oncol , vol.16 , pp. 261-266
    • Shamma, A.1    Doki, Y.2    Shiozaki, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.