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European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 335-342

Selenadiazole derivatives as potent thioredoxin reductase inhibitors that enhance the radiosensitivity of cancer cells

(5) Liang, Yuan Wei a Zheng, Junsheng b Li, Xiaoling a Zheng, Wenjie a Chen, Tianfeng a

a JINAN UNIVERSITY (China)

b THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY (China)

Author keywords

Radiosensitization; ROS; Selenadiazole; Thioredoxin reductase

Indexed keywords

1,2,3 SELENADIAZOLE DERIVATIVE; ENZYME INHIBITOR; PYRROLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE; OXIDOREDUCTASE INHIBITOR; RADIOSENSITIZING AGENT; SELENADIAZOLE DERIVATIVE; SELENAZOLE DERIVATIVE; THIOREDOXIN REDUCTASE INHIBITOR; ORGANOSELENIUM DERIVATIVE;

A375 CELL LINE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IRRADIATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; RADIOSENSITIVITY; MELANOMA CELL; X RAY; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GAMMA RADIATION; METABOLISM; NEOPLASMS; PATHOLOGY; RADIATION DOSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

APOPTOSIS; AZOLES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GAMMA RAYS; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; ORGANOSELENIUM COMPOUNDS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN-DISULFIDE REDUCTASE; TUMOR CELLS, CULTURED;

EID: 84904557484 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2014.07.032 Document Type: Article

Times cited : (53)

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