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Volumn 30, Issue 1, 2013, Pages 125-130

SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein

Author keywords

Bcl 2; Breast cancer; Ki67; Silent mating type information regulation 2 homologue 1

Indexed keywords

KI 67 ANTIGEN; PROTEIN BCL 2; SIRTINOL; SIRTUIN 1;

EID: 84878184564     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2470     Document Type: Article
Times cited : (30)

References (35)
  • 1
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • DOI 10.1146/annurev.biochem.73.011303.073651
    • Blander G and Guarente L: The Sir2 family of protein deacetylases. Annu Rev Biochem 73: 417-435, 2004. (Pubitemid 39050375)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 2
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: Insights into their biological function
    • DOI 10.1042/BJ20070140
    • Michan S and Sinclair D: Sirtuins in mammals: insights into their biological function. Biochem J 404: 1-13, 2007. (Pubitemid 46788079)
    • (2007) Biochemical Journal , vol.404 , Issue.1 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 4
    • 33845396682 scopus 로고    scopus 로고
    • SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity
    • Dai JM, Wang ZY, Sun DC, Lin RX and Wang SQ: SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity. J Cell Physiol 210: 161-166, 2007.
    • (2007) J Cell Physiol , vol.210 , pp. 161-166
    • Dai, J.M.1    Wang, Z.Y.2    Sun, D.C.3    Lin, R.X.4    Wang, S.Q.5
  • 5
    • 35748949600 scopus 로고    scopus 로고
    • Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
    • DOI 10.1042/BJ20070151
    • Wong S and Weber JD: Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J 407: 451-460, 2007. (Pubitemid 350058478)
    • (2007) Biochemical Journal , vol.407 , Issue.3 , pp. 451-460
    • Wong, S.1    Weber, J.D.2
  • 7
    • 66849138420 scopus 로고    scopus 로고
    • Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells
    • Jung-Hynes B and Ahmad N: Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. Cell Cycle 8: 1478-1483, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 1478-1483
    • Jung-Hynes, B.1    Ahmad, N.2
  • 9
    • 59649126261 scopus 로고    scopus 로고
    • Deacetylation of cortactin by SIRT1 promotes cell migration
    • Zhang Y, Zhang M, Dong H, et al: Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene 28: 445-460, 2009.
    • (2009) Oncogene , vol.28 , pp. 445-460
    • Zhang, Y.1    Zhang, M.2    Dong, H.3
  • 11
    • 67650563916 scopus 로고    scopus 로고
    • SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
    • Kabra N, Li Z, Chen L, et al: SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem 284: 18210-18217, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 18210-18217
    • Kabra, N.1    Li, Z.2    Chen, L.3
  • 12
    • 33845671339 scopus 로고    scopus 로고
    • + cancer stem cells in glioblastoma
    • + cancer stem cells in glioblastoma. Mol Cancer 5: 67, 2006.
    • (2006) Mol Cancer , vol.5 , pp. 67
    • Liu, G.1    Yuan, X.2    Zeng, Z.3
  • 13
    • 53449083751 scopus 로고    scopus 로고
    • SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
    • Jang KY, Hwang SH, Kwon KS, et al: SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma. Am J Surg Pathol 32: 1523-1531, 2008.
    • (2008) Am J Surg Pathol , vol.32 , pp. 1523-1531
    • Jang, K.Y.1    Hwang, S.H.2    Kwon, K.S.3
  • 14
    • 27144475816 scopus 로고    scopus 로고
    • Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
    • DOI 10.1038/sj.leu.2403910, PII 2403910
    • Bradbury CA, Khanim FL, Hayden R, et al: Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 19: 1751-1759, 2005. (Pubitemid 41486152)
    • (2005) Leukemia , vol.19 , Issue.10 , pp. 1751-1759
    • Bradbury, C.A.1    Khanim, F.L.2    Hayden, R.3    Bunce, C.M.4    White, D.A.5    Drayson, M.T.6    Craddock, C.7    Turner, B.M.8
  • 15
    • 34250897968 scopus 로고    scopus 로고
    • SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein
    • DOI 10.1016/j.molcel.2007.05.029, PII S1097276507003309
    • Yuan Z, Zhang X, Sengupta N, Lane WS and Seto E: SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell 27: 149-162, 2007. (Pubitemid 46991383)
    • (2007) Molecular Cell , vol.27 , Issue.1 , pp. 149-162
    • Yuan, Z.1    Zhang, X.2    Sengupta, N.3    Lane, W.S.4    Seto, E.5
  • 16
    • 28544451205 scopus 로고    scopus 로고
    • Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1
    • DOI 10.1158/0008-5472.CAN-05-2002
    • Chu F, Chou PM, Zheng X, Mirkin BL and Rebbaa A: Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. Cancer Res 65: 10183-10187, 2005. (Pubitemid 41743708)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10183-10187
    • Chu, F.1    Chou, P.M.2    Zheng, X.3    Mirkin, B.L.4    Rebbaa, A.5
  • 18
    • 15944365507 scopus 로고    scopus 로고
    • Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells
    • DOI 10.1111/j.1365-2443.2005.00836.x
    • Matsushita N, Takami Y, Kimura M, et al: Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells 10: 321-332, 2005. (Pubitemid 40443684)
    • (2005) Genes to Cells , vol.10 , Issue.4 , pp. 321-332
    • Matsushita, N.1    Takami, Y.2    Kimura, M.3    Tachiiri, S.4    Ishiai, M.5    Nakayama, T.6    Takata, M.7
  • 19
    • 47249154705 scopus 로고    scopus 로고
    • A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
    • Kojima K, Ohhashi R, Fujita Y, et al: A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells. Biochem Biophys Res Commun 373: 423-428, 2008.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 423-428
    • Kojima, K.1    Ohhashi, R.2    Fujita, Y.3
  • 20
    • 65349096174 scopus 로고    scopus 로고
    • A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
    • Yuan J, Minter-Dykhouse K and Lou Z: A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol 185: 203-211, 2009.
    • (2009) J Cell Biol , vol.185 , pp. 203-211
    • Yuan, J.1    Minter-Dykhouse, K.2    Lou, Z.3
  • 21
    • 44849096876 scopus 로고    scopus 로고
    • The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    • Firestein R, Blander G, Michan S, et al: The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3: e2020, 2008.
    • (2008) PLoS One , vol.3
    • Firestein, R.1    Blander, G.2    Michan, S.3
  • 23
    • 53149137486 scopus 로고    scopus 로고
    • Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    • Wang RH, Sengupta K, Li C, et al: Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14: 312-323, 2008.
    • (2008) Cancer Cell , vol.14 , pp. 312-323
    • Wang, R.H.1    Sengupta, K.2    Li, C.3
  • 24
    • 33744774692 scopus 로고    scopus 로고
    • SIRT1: Tumor promoter or tumor suppressor?
    • Lim CS: SIRT1: tumor promoter or tumor suppressor? Med Hypotheses 67: 341-344, 2006.
    • (2006) Med Hypotheses , vol.67 , pp. 341-344
    • Lim, C.S.1
  • 25
    • 84873691430 scopus 로고    scopus 로고
    • The role of SIRT1 in tumorigenesis
    • Li K and Luo J: The role of SIRT1 in tumorigenesis. N Am J Med Sci 4: 104-106, 2011.
    • (2011) N Am J Med Sci , vol.4 , pp. 104-106
    • Li, K.1    Luo, J.2
  • 27
    • 77954647009 scopus 로고    scopus 로고
    • Balance between SIRT1 and DBC1 expression is lost in breast cancer
    • Sung JY, Kim R, Kim JE and Lee J: Balance between SIRT1 and DBC1 expression is lost in breast cancer. Cancer Sci 101: 1738-1744, 2010.
    • (2010) Cancer Sci , vol.101 , pp. 1738-1744
    • Sung, J.Y.1    Kim, R.2    Kim, J.E.3    Lee, J.4
  • 28
    • 33646254136 scopus 로고    scopus 로고
    • Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    • Heltweg B, Gatbonton T, Schuler AD, et al: Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66: 4368-4377, 2006.
    • (2006) Cancer Res , vol.66 , pp. 4368-4377
    • Heltweg, B.1    Gatbonton, T.2    Schuler, A.D.3
  • 29
    • 30544445468 scopus 로고    scopus 로고
    • Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
    • DOI 10.1038/sj.onc.1209049, PII 1209049
    • Ota H, Tokunaga E, Chang K, et al: Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25: 176-185, 2006. (Pubitemid 43083679)
    • (2006) Oncogene , vol.25 , Issue.2 , pp. 176-185
    • Ota, H.1    Tokunaga, E.2    Chang, K.3    Hikasa, M.4    Iijima, K.5    Eto, M.6    Kozaki, K.7    Akishita, M.8    Ouchi, Y.9    Kaneki, M.10
  • 30
    • 28544444366 scopus 로고    scopus 로고
    • Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
    • DOI 10.1158/0008-5472.CAN-05-1923
    • Ford J, Jiang M and Milner J: Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 65: 10457-10463, 2005. (Pubitemid 41743740)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10457-10463
    • Ford, J.1    Jiang, M.2    Milner, J.3
  • 31
    • 43549112759 scopus 로고    scopus 로고
    • Bcl-2-family proteins and hematologic malignancies: History and future prospects
    • Reed JC: Bcl-2-family proteins and hematologic malignancies: history and future prospects. Blood 111: 3322-3330, 2008.
    • (2008) Blood , vol.111 , pp. 3322-3330
    • Reed, J.C.1
  • 32
    • 77953494288 scopus 로고    scopus 로고
    • Targeting mitochondria for cancer therapy
    • Hockenbery DM: Targeting mitochondria for cancer therapy. Environ Mol Mutagen 51: 476-489, 2010.
    • (2010) Environ Mol Mutagen , vol.51 , pp. 476-489
    • Hockenbery, D.M.1
  • 33
  • 34
    • 0012731458 scopus 로고    scopus 로고
    • LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members
    • DOI 10.1016/S0304-3835(03)00148-4
    • Zhang M, Guo R, Zhai Y and Yang D: LIGHT sensitizes IFNgamma-mediated apoptosis of MDA-MB-231 breast cancer cells leading to down-regulation of anti-apoptosis Bcl-2 family members. Cancer Lett 195: 201-210, 2003. (Pubitemid 36603330)
    • (2003) Cancer Letters , vol.195 , Issue.2 , pp. 201-210
    • Zhang, M.1    Guo, R.2    Zhai, Y.3    Yang, D.4
  • 35
    • 80051761743 scopus 로고    scopus 로고
    • The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
    • Kelly PN and Strasser A: The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell Death Differ 18: 1414-1424, 2011.
    • (2011) Cell Death Differ , vol.18 , pp. 1414-1424
    • Kelly, P.N.1    Strasser, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.