Overexpression of protein tyrosine phosphatase 1B impairs glucose-stimulated insulin secretion in INS-1 cells

Minerva Endocrinologica

Volumn 41, Issue 1, 2016, Pages 1-9

  Lu, Bin ^a   Gu, Ping ^a   Xu, Yixin ^a   Ye, Xiaozhen ^a   Wang, Yingzhijie ^a   Du, Hong ^a   Shao, Jiaqing ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Insulin resistance; Insulin secreting cells; Non receptor type 1; Protein tyrosine phosphatase

Indexed keywords

ADENOVIRUS VECTOR; GLUCOKINASE; GLUCOSE TRANSPORTER 2; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE 1B; GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, RAT; PROTEIN TYROSINE PHOSPHATASE; PTPN1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL LINE; GENETICS; MALE; METABOLISM; RAT;

ANIMALS; CELL LINE; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEIN TYROSINE PHOSPHATASES; RATS;

EID: 84992476946     PISSN: 03911977     EISSN: 18271634     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Harbeck MC, Louie DC, Howland J, Wolf BA, Rothenberg PL. Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. Diabetes 1996;45:711-7.
2. Leibiger IB, Leibiger B, Moede T, Berggren PO. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol Cell 1998;1:933-8.
3. Kulkarni RN. Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function. Biochem Soc Trans 2002;30:317-22.
4. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, et al. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 2004;286:E41-9.
5. Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999;96:329-39.
6. Aspinwall CA, Lakey JR, Kennedy RT. Insulin-stimulated insulin secretion in single pancreatic beta cells. J Biol Chem 1999;274:6360-5.
7. Halperin F, Lopez X, Manning R, Kahn CR, Kulkarni RN, Goldfine AB. Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans. Diabetes 2012;61:301-9.
8. Dadke SS, Li HC, Kusari AB, Begum N, Kusari J. Elevated expression and activity of protein-tyrosine phosphatase 1B in skeletal muscle of insulin-resistant type II diabetic Goto-Kakizaki rats. Biochem Biophys Res Commun 2000;274:583-9.
9. Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, et al. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem 2004;279:24844-51.
10. Egawa K, Maegawa H, Shimizu S, Morino K, Nishio Y, Bryer-Ash M, et al. Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in L6 myocytes and Fao hepatoma cells. J Biol Chem 2001;276:10207-11.
11. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999;283:1544-8.
12. Lu B, Wu H, Gu P, Du H, Shao J, Wang J, et al. Improved glucose-stimulated insulin secretion by intra-islet inhibition of protein-tyrosine phosphatase 1B expression in rats fed a high-fat diet. J Endocrinol Invest 2012;35:63-70.
13. Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, Hanahan D, et al. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 1999;104:R69-75.
14. Leibiger IB, Leibiger B, Berggren PO. Insulin signaling in the pancreatic beta-cell. Annu Rev Nutr 2008;28:233-51.
15. Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, et al. Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice Diabetes 2003;52:21-8.
16. Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem 2005;280:15038-46.
17. Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, et al. Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation. J Biol Chem 2000;275:18318-26.
18. Fernandez-Ruiz R, Vieira E, Garcia-Roves PM, Gomis R. Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass. PLoS One 2014;9:e90344.
19. Kim WH, Lee JW, Suh YH, Hong SH, Choi JS, Lim JH, et al. Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells. Diabetes 2005;54:2602-11.
20. Da Silva Xavier G, Qian Q, Cullen PJ, Rutter GA. Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing. Biochem J 2004;377:149-58.
21. Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 2001;7:559-70.