Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/protein kinase B activation

Journal of Biological Chemistry

Volumn 275, Issue 24, 2000, Pages 18318-18326

  Venable, Carol L ^a   Frevert, Ernst U ^a   Kim, Young Bum ^a   Fischer, Britta M ^a   Kamatkar, Shubhangi ^a   Neel, Benjamin G ^a,b   Kahn, Barbara B ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c Diabetes Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; COS CELLS; DEOXYGLUCOSE; ENZYME ACTIVATION; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SRC HOMOLOGY DOMAINS;

ADENOVIRIDAE; ANIMALIA; RODENTIA;

EID: 0034674651     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M908392199     Document Type: Article

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