Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans

Diabetes

Volumn 61, Issue 2, 2012, Pages 301-309

  Halperin, Florencia ^a,b,c   Lopez, Ximena ^a,b,d   Manning, Raquel ^a   Kahn, C Ronald ^a,c   Kulkarni, Rohit N ^a,c   Goldfine, Allison B ^a,b,c  

^a JOSLIN DIABETES CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN ASPART;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE STIMULATED INSULIN SECRETION; HORMONE ACTION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADULT; BLOOD GLUCOSE; C-PEPTIDE; CALCIUM; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED;

EID: 84856537444     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1067     Document Type: Article

References (49)

1. Kulkarni RN, Winnay JN, Daniels M, et al. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 1999;104:R69-R75 (Pubitemid 30053195)
2. Luciani DS, Johnson JD. Acute effects of insulin on beta-cells from transplantable human islets. Mol Cell Endocrinol 2005;241:88-98 (Pubitemid 41262174)
3. Muller D, Huang GC, Amiel S, Jones PM, Persaud SJ. Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression. Diabetes 2006;55:2835-2842 (Pubitemid 44923684)
4. Lingohr MK, Dickson LM, Wrede CE, McCuaig JF, Myers MG Jr, Rhodes CJ. IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells. Mol Cell Endocrinol 2003;204:85-99 (Pubitemid 36871555)
5. Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 2001;108: 1631-1638 (Pubitemid 33144873)
6. Hashimoto N, Kido Y, Uchida T, et al. Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet 2006; 38:589-593
7. Tuttle RL, Gill NS, Pugh W, et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med 2001;7:1133-1137 (Pubitemid 33010022)
8. Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 1999;96:329-339 (Pubitemid 29077587)
9. Aspinwall CA, Lakey JR, Kennedy RT. Insulin-stimulated insulin secretion in single pancreatic beta cells. J Biol Chem 1999;274:6360-6365 (Pubitemid 29111049)
10. Gunton JE, Kulkarni RN, Yim S, et al. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005;122:337-349 (Pubitemid 41127137)
11. DeFronzo RA, Binder C, Wahren J, Felig P, Ferrannini E, Faber OK. Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia. Acta Endocrinol (Copenh) 1981;98:81-86 (Pubitemid 11023925)
12. Waldhäusl WK, Gasić S, Bratusch-Marrain P, Korn A, Nowotny P. Feedback inhibition by biosynthetic human insulin of insulin release in healthy human subjects. Am J Physiol 1982;243:E476-E482 (Pubitemid 13166230)
13. Garvey WT, Revers RR, Kolterman OG, Rubenstein AH, Olefsky JM. Modulation of insulin secretion by insulin and glucose in type II diabetes mellitus. J Clin Endocrinol Metab 1985;60:559-568 (Pubitemid 15133861)
14. Argoud GM, Schade DS, Eaton RP. Insulin suppresses its own secretion in vivo. Diabetes 1987;36:959-962 (Pubitemid 17136810)
15. Zilker T, Paterek K, Ermler R, Bottermann P. Studies on the question of a possible autoregulation of insulin secretion (author's translation). Klin Wochenschr 1977;55:475-479 [in German] (Pubitemid 8085564)
16. Shima K, Morishta S, Sawazaki N, Tanaka R, Tarui S. Failure of exogenous insulin to inhibit insulin secretion in man. Horm Metab Res 1977;9:441-443 (Pubitemid 8247972)
17. Elahi D, Nagulesparan M, Hershcopf RJ, et al. Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity. N Engl J Med 1982;306:1196-1202 (Pubitemid 12158849)
18. Kraegen EW, Lazarus L, Campbell LV. Failure of insulin infusion during euglycemia to influence endogenous basal insulin secretion. Metabolism 1983;32:622-627 (Pubitemid 13099168)
19. Best CH, Haist RE. The effect of insulin administration on the insulin content of the pancreas. J Physiol 1941;100:142-146
20. Bouche C, Lopez X, Fleischman A, et al. Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci USA 2010;107:4770-4775
21. Anderwald C, Tura A, Grassi A, et al. Insulin infusion during normoglycemia modulates insulin secretion according to whole-body insulin sensitivity. Diabetes Care 2011;34:437-441
22. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011;34(Suppl. 1):S62-S69
23. McGuire EA, Helderman JH, Tobin JD, Andres R, Berman M. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol 1976;41:565-573
24. Goldfine AB, Ebbeling CB, Ludwig DS. Antegrade intravenous catheterization for metabolic studies in man. Diabetologia 2002;45:1742-1743 (Pubitemid 35478149)
25. Rizza RA, Mandarino LJ, Gerich JE. Mechanisms of insulin resistance in man. Assessment using the insulin dose-response curve in conjunction with insulin-receptor binding. Am J Med 1981;70:169-176 (Pubitemid 11183523)
26. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223 (Pubitemid 9249478)
27. Brange J, Owens DR, Kang S, Vølund A. Monomeric insulins and their experimental and clinical implications. Diabetes Care 1990;13:923-954 (Pubitemid 20260734)
28. Kawamori D, Kurpad AJ, Hu J, et al. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab 2009;9:350-361
29. Assmann A, Hinault C, Kulkarni RN. Growth factor control of pancreatic islet regeneration and function. Pediatr Diabetes 2009;10:14-32
30. Withers DJ, Gutierrez JS, Towery H, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998;391:900-904 (Pubitemid 28157668)
31. Cho H, Mu J, Kim JK, et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001;292:1728-1731 (Pubitemid 32506248)
32. Kaneko K, Ueki K, Takahashi N, et al. Class IA phosphatidylinositol 3-kinase in pancreatic b cells controls insulin secretion by multiple mechanisms. Cell Metab 2010;12:619-632
33. Leibiger B, Wahlander K, Berggren PO, Leibiger IB. Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription. J Biol Chem 2000;275:30153-30156
34. Westerlund J, Wolf BA, Bergsten P. Glucose-dependent promotion of insulin release from mouse pancreatic islets by the insulin-mimetic compound L-783,281. Diabetes 2002;51(Suppl. 1):S50-S52 (Pubitemid 34761494)
35. Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, Kennedy RT. Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta-cells. J Biol Chem 2000;275:22331-22338 (Pubitemid 30621818)
36. Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN. Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol 2009;29:3219-3228
37. Federici M, Hribal M, Perego L, et al. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 2001;50:1290-1301 (Pubitemid 32500161)
38. Hribal ML, Perego L, Lovari S, et al. Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans. FASEB J 2003;17: 1340-1342
39. Ratzmann KP, Schulz B. Further support for inhibition of endogenous insulin secretion by exogenous insulin. Exp Clin Endocrinol 1985;85:75-80 (Pubitemid 15105743)
40. Van Cauter E, Mestrez F, Sturis J, Polonsky KS. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 1992;41:368-377
41. Neerman-Arbez M, Halban PA. Novel, non-crinophagic, degradation of connecting peptide in transformed pancreatic beta cells. J Biol Chem 1993; 268:16248-16252 (Pubitemid 23229922)
42. Ohgawara H, Tasaka Y, Kosaka K, Shizume K. Effect of exogenous bonito insulin on endogenous insulin secretion in dogs. Endocrinol Jpn 1974;21: 147-156
43. Lopez X, Cypess A, Manning R, O'Shea S, Kulkarni RN, Goldfine AB. Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids. J Clin Endocrinol Metab 2011;96:3811-3821
44. Samols E, Marri G, Marks V. Promotion of insulin secretion by glucagon. Lancet 1965;2:415-416
45. Cooperberg BA, Cryer PE. Insulin reciprocally regulates glucagon secretion in humans. Diabetes 2010;59:2936-2940
46. Helderman JH, Elahi D, Andersen DK, et al. Prevention of the glucose intolerance of thiazide diuretics by maintenance of body potassium. Diabetes 1983;32:106-111 (Pubitemid 13180341)
47. Donath MY, Böni-Schnetzler M, Ellingsgaard H, Ehses JA. Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 2009;24:325-331
48. Guardado-Mendoza R, Davalli AM, Chavez AO, et al. Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci USA 2009;106:13992-13997
49. Jurgens CA, Toukatly MN, Fligner CL, et al. β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol 2011;178:2632-2640