Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 43, 2016, Pages E6572-E6581

  Liu, Ce Feng ^a,b   Brandt, Gabriel S ^b,c   Hoang, Quyen Q ^b,d   Naumova, Natalia ^e,j   Lazarevic, Vanja ^f,k   Hwang, Eun Sook ^f,g   Dekker, Job ^e   Glimcher, Laurie H ^f,h,i,l   Ringe, Dagmar ^b   Petsko, Gregory A ^a,b  

^a FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c FRANKLIN AND MARSHALL COLLEGE   (United States)

^d INDIANA UNIVERSITY   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g Ewha Womans University   (South Korea)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ HARVARD UNIVERSITY   (United States)

^j Epinomics   (United States)

^k NATIONAL CANCER INSTITUTE   (United States)

^l DANA FARBER CANCER INSTITUTE   (United States)

more..

Author keywords

Crystal structure; DNA looping; Master regulator; T bet; Transcriptional regulation

Indexed keywords

CD4 ANTIGEN; PALINDROMIC DNA; TRANSCRIPTION FACTOR T BET; DNA; PROTEIN BINDING; RECOMBINANT PROTEIN; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BINDING SITE; CHROMOSOME; CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DNA CONFORMATION; ESCHERICHIA COLI; FLUORESCENCE ANALYSIS; GENE LOCUS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR RECOGNITION; MOUSE; MUS MUSCULUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CHROMATIN; ENHANCER REGION; GENE EXPRESSION; GENETICS; GENOME; INVERTED REPEAT; METABOLISM; MOLECULAR MODEL; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHROMATIN; CRYSTALLOGRAPHY, X-RAY; DNA; ENHANCER ELEMENTS, GENETIC; ESCHERICHIA COLI; GENE EXPRESSION; GENOME; INVERTED REPEAT SEQUENCES; MICE; MODELS, MOLECULAR; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; T-BOX DOMAIN PROTEINS; XENOPUS LAEVIS;

EID: 84992422455     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1613914113     Document Type: Article

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