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Volumn 110, Issue 7, 2007, Pages 2494-2500

Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNγ/Stat1 signals

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 12; STAT1 PROTEIN; STAT4 PROTEIN; TRANSCRIPTION FACTOR T BET;

EID: 34948833693     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-11-058271     Document Type: Article
Times cited : (68)

References (39)
  • 2
    • 0034672647 scopus 로고    scopus 로고
    • Cloning and characterization of a new member of the T-box gene family
    • Zhang WX, Yang SY. Cloning and characterization of a new member of the T-box gene family. Genomics. 2000;70:41-48.
    • (2000) Genomics , vol.70 , pp. 41-48
    • Zhang, W.X.1    Yang, S.Y.2
  • 3
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • Finotto S, Neurath MF, Glickman JN, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002;295:336-338.
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1    Neurath, M.F.2    Glickman, J.N.3
  • 4
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    • Neurath MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002;195:1129-1143.
    • (2002) J Exp Med , vol.195 , pp. 1129-1143
    • Neurath, M.F.1    Weigmann, B.2    Finotto, S.3
  • 5
    • 3142724732 scopus 로고    scopus 로고
    • Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    • Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med. 2004;200:79-87.
    • (2004) J Exp Med , vol.200 , pp. 79-87
    • Bettelli, E.1    Sullivan, B.2    Szabo, S.J.3    Sobel, R.A.4    Glimcher, L.H.5    Kuchroo, V.K.6
  • 8
    • 8444242090 scopus 로고    scopus 로고
    • Cutting edge: Immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet
    • Way SS, Wilson CB. Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet. J Immunol. 2004;173:5918-5922.
    • (2004) J Immunol , vol.173 , pp. 5918-5922
    • Way, S.S.1    Wilson, C.B.2
  • 9
    • 1842785209 scopus 로고    scopus 로고
    • T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells
    • Townsend MJ, Weinmann AS, Matsuda JL, et al. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity. 2004;20:477-494.
    • (2004) Immunity , vol.20 , pp. 477-494
    • Townsend, M.J.1    Weinmann, A.S.2    Matsuda, J.L.3
  • 10
    • 0242410712 scopus 로고    scopus 로고
    • Control of effector CD8+ T cell function by the transcription factor
    • Pearce EL, Mullen AC, Martins GA, et al. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science. 2003;302:1041-1043.
    • (2003) Eomesodermin. Science , vol.302 , pp. 1041-1043
    • Pearce, E.L.1    Mullen, A.C.2    Martins, G.A.3
  • 11
    • 0033791427 scopus 로고    scopus 로고
    • Transcriptional regulation of Th1/Th2 polarization
    • Rengarajan J, Szabo SJ, Glimcher LH. Transcriptional regulation of Th1/Th2 polarization. Immunol Today. 2000;21:479-483.
    • (2000) Immunol Today , vol.21 , pp. 479-483
    • Rengarajan, J.1    Szabo, S.J.2    Glimcher, L.H.3
  • 12
    • 0035827347 scopus 로고    scopus 로고
    • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
    • Mullen AC, High FA, Hutchins AS, et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 2001;292:1907-1910.
    • (2001) Science , vol.292 , pp. 1907-1910
    • Mullen, A.C.1    High, F.A.2    Hutchins, A.S.3
  • 13
    • 0035910037 scopus 로고    scopus 로고
    • T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells
    • Lighvani AA, Frucht DM, Jankovic D, et al. T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A. 2001;98:15137-15142.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 15137-15142
    • Lighvani, A.A.1    Frucht, D.M.2    Jankovic, D.3
  • 14
    • 0035997908 scopus 로고    scopus 로고
    • T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
    • Afkarian M, Sedy JR, Yang J, et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol. 2002;3:549-557.
    • (2002) Nat Immunol , vol.3 , pp. 549-557
    • Afkarian, M.1    Sedy, J.R.2    Yang, J.3
  • 15
    • 33645065358 scopus 로고    scopus 로고
    • T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNγ gene acetylation and transcription
    • Usui T, Preiss JC, Kanno Y, et al. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNγ gene acetylation and transcription. J Exp Med. 2006;203:755-766.
    • (2006) J Exp Med , vol.203 , pp. 755-766
    • Usui, T.1    Preiss, J.C.2    Kanno, Y.3
  • 16
    • 0037013930 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    • Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med. 2002;195:1499-1505.
    • (2002) J Exp Med , vol.195 , pp. 1499-1505
    • Gorelik, L.1    Constant, S.2    Flavell, R.A.3
  • 17
    • 0037342749 scopus 로고    scopus 로고
    • GATA-3 suppresses Th1 development by down-regulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
    • Usui T, Nishikomori R, Kitani A, Strober W. GATA-3 suppresses Th1 development by down-regulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet. Immunity. 2003;18:415-428.
    • (2003) Immunity , vol.18 , pp. 415-428
    • Usui, T.1    Nishikomori, R.2    Kitani, A.3    Strober, W.4
  • 18
    • 3142686560 scopus 로고    scopus 로고
    • Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet
    • Miller AT, Wilcox HM, Lai Z, Berg LJ. Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity. 2004;21:67-80.
    • (2004) Immunity , vol.21 , pp. 67-80
    • Miller, A.T.1    Wilcox, H.M.2    Lai, Z.3    Berg, L.J.4
  • 19
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430-433.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 20
    • 0033594812 scopus 로고    scopus 로고
    • Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2
    • Rui L, Carter-Su C. Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc Natl Acad Sci U S A. 1999;96:7172-7177.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7172-7177
    • Rui, L.1    Carter-Su, C.2
  • 21
    • 0141446329 scopus 로고    scopus 로고
    • Differential chemokine and chemokine receptor gene induction by ischemia, alloantigen, and gene transfer in cardiac grafts
    • Chen D, Ding Y, Schroppel B, et al. Differential chemokine and chemokine receptor gene induction by ischemia, alloantigen, and gene transfer in cardiac grafts. Am J Transplant. 2003;3:1216-1229.
    • (2003) Am J Transplant , vol.3 , pp. 1216-1229
    • Chen, D.1    Ding, Y.2    Schroppel, B.3
  • 22
    • 0026327416 scopus 로고
    • High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons
    • McKendry R, John J, Flavell D, Muller M, Kerr IM, Stark GR. High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons. Proc Natl Acad Sci U S A. 1991;8:11455-11459.
    • (1991) Proc Natl Acad Sci U S A , vol.8 , pp. 11455-11459
    • McKendry, R.1    John, J.2    Flavell, D.3    Muller, M.4    Kerr, I.M.5    Stark, G.R.6
  • 23
    • 0037310860 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses
    • Ding Y, Chen D, Tarcsafalvi A, Su R, Qin L, Bromberg JS. Suppressor of cytokine signaling 1 inhibits IL-10-mediated immune responses. J Immunol. 2003;170:1383-1391.
    • (2003) J Immunol , vol.170 , pp. 1383-1391
    • Ding, Y.1    Chen, D.2    Tarcsafalvi, A.3    Su, R.4    Qin, L.5    Bromberg, J.S.6
  • 24
    • 14044268797 scopus 로고    scopus 로고
    • IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation
    • Yang Y, Ochando J, Yopp A, Bromberg JS, Ding Y. IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J Immunol. 2005;174:2720-2729.
    • (2005) J Immunol , vol.174 , pp. 2720-2729
    • Yang, Y.1    Ochando, J.2    Yopp, A.3    Bromberg, J.S.4    Ding, Y.5
  • 25
    • 0035892751 scopus 로고    scopus 로고
    • Differential IL-10R1 expression plays a critical role in IL-10 mediated immune regulation
    • Ding Y, Qin L, Zamarin D, et al. Differential IL-10R1 expression plays a critical role in IL-10 mediated immune regulation. J Immunol. 2001;167:6884-6892.
    • (2001) J Immunol , vol.167 , pp. 6884-6892
    • Ding, Y.1    Qin, L.2    Zamarin, D.3
  • 26
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996;382:174-177.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 27
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13:715-725.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 28
    • 0037144547 scopus 로고    scopus 로고
    • Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
    • Nguyen KB, Watford WT, Salomon R, et al. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science. 2002;297:2063-2066.
    • (2002) Science , vol.297 , pp. 2063-2066
    • Nguyen, K.B.1    Watford, W.T.2    Salomon, R.3
  • 29
    • 0030445948 scopus 로고    scopus 로고
    • A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
    • Presky DH, Yang H, Minetti LJ, et al. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A. 1996;93:14002-14007.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14002-14007
    • Presky, D.H.1    Yang, H.2    Minetti, L.J.3
  • 30
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper (TH1) and TH2 cells
    • Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper (TH1) and TH2 cells. J Exp Med. 1997;185:817-824.
    • (1997) J Exp Med , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 31
    • 2442503239 scopus 로고    scopus 로고
    • ChIP-based strategies to uncover transcription factor target genes in the immune system
    • Weinmann AS. Novel ChIP-based strategies to uncover transcription factor target genes in the immune system. Nat Rev Immunol. 2004;4:381-386.
    • (2004) Nat Rev Immunol , vol.4 , pp. 381-386
    • Novel, W.A.S.1
  • 32
    • 0029001660 scopus 로고
    • Components of a Stat recognition code: Evidence for two layers of molecular selectivity
    • Schindler U, Wu P, Rothe M, Brasseur M, McKnight SL. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity. 1995;2:689-697.
    • (1995) Immunity , vol.2 , pp. 689-697
    • Schindler, U.1    Wu, P.2    Rothe, M.3    Brasseur, M.4    McKnight, S.L.5
  • 33
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • Horvath CM, Wen Z, Darnell JE Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 1995;9:984-994.
    • (1995) Genes Dev , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell Jr, J.E.3
  • 34
    • 0029739627 scopus 로고    scopus 로고
    • Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
    • Xu X, Sun YL, Hoey T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science. 1996;273:794-797.
    • (1996) Science , vol.273 , pp. 794-797
    • Xu, X.1    Sun, Y.L.2    Hoey, T.3
  • 35
    • 0035794217 scopus 로고    scopus 로고
    • DNA binding specificity of different STAT proteins: Comparison of in vitro specificity with natural target sites
    • Ehret GB, Reichenbach P, Schindler U, et al. DNA binding specificity of different STAT proteins: comparison of in vitro specificity with natural target sites. J Bio Chem. 2001;276:6675-6688.
    • (2001) J Bio Chem , vol.276 , pp. 6675-6688
    • Ehret, G.B.1    Reichenbach, P.2    Schindler, U.3
  • 36
    • 0037790710 scopus 로고    scopus 로고
    • Molecular basis of the inflammatory response to adenovirus vectors
    • Liu Q, Muruve DA. Molecular basis of the inflammatory response to adenovirus vectors. Gene Ther. 2003;10:935-940.
    • (2003) Gene Ther , vol.10 , pp. 935-940
    • Liu, Q.1    Muruve, D.A.2
  • 37
    • 0029903770 scopus 로고    scopus 로고
    • DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: Interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites
    • Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, Darnell JE Jr. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J. 1996;15:5616-5626.
    • (1996) EMBO J , vol.15 , pp. 5616-5626
    • Vinkemeier, U.1    Cohen, S.L.2    Moarefi, I.3    Chait, B.T.4    Kuriyan, J.5    Darnell Jr., J.E.6
  • 38
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    • Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002;295:338-342.
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3    Satoskar, A.R.4    Sleckman, B.P.5    Glimcher, L.H.6
  • 39
    • 33751584436 scopus 로고    scopus 로고
    • IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation
    • Takemoto N, Intlekofer AM, Northrup JT, Wherry EJ, Reiner SL. IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J Immunol. 2006;177:7515-7519.
    • (2006) J Immunol , vol.177 , pp. 7515-7519
    • Takemoto, N.1    Intlekofer, A.M.2    Northrup, J.T.3    Wherry, E.J.4    Reiner, S.L.5


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