-
1
-
-
84877921536
-
A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis
-
[1] Abolmaali, S.S., Tamaddon, A.M., Dinarvand, R., A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis. Cancer Chemother. Pharmacol. 71:5 (2013), 1115–1130.
-
(2013)
Cancer Chemother. Pharmacol.
, vol.71
, Issue.5
, pp. 1115-1130
-
-
Abolmaali, S.S.1
Tamaddon, A.M.2
Dinarvand, R.3
-
2
-
-
84856082845
-
Methotrexate: a detailed review on drug delivery and clinical aspects
-
[2] Khan, Z.A., Tripathi, R., Mishra, B., Methotrexate: a detailed review on drug delivery and clinical aspects. Expert Opin. Drug Deliv. 9:2 (2012), 151–169.
-
(2012)
Expert Opin. Drug Deliv.
, vol.9
, Issue.2
, pp. 151-169
-
-
Khan, Z.A.1
Tripathi, R.2
Mishra, B.3
-
3
-
-
39749098413
-
Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells
-
[3] Fotoohi, A.K., Albertioni, F., Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells. Leuk. Lymphoma 49:3 (2008), 26–410.
-
(2008)
Leuk. Lymphoma
, vol.49
, Issue.3
, pp. 26-410
-
-
Fotoohi, A.K.1
Albertioni, F.2
-
4
-
-
0342434456
-
Resistance mechanisms to methotrexate in tumors
-
[4] Bertino, J.R., Goker, E., Gorlick, R., Li, W.W., Banerjee, D., Resistance mechanisms to methotrexate in tumors. Oncologist 1:4 (1996), 223–226.
-
(1996)
Oncologist
, vol.1
, Issue.4
, pp. 223-226
-
-
Bertino, J.R.1
Goker, E.2
Gorlick, R.3
Li, W.W.4
Banerjee, D.5
-
5
-
-
0028979473
-
Activation and cytotoxicity of 2-alpha-aminoacyl prodrugs of methotrexate
-
[5] Smal, M.A., Dong, Z., Cheung, H.T., Asano, Y., Escoffier, L., Costello, M., Tattersall, M.H., Activation and cytotoxicity of 2-alpha-aminoacyl prodrugs of methotrexate. Biochem. Pharmacol. 49:4 (1995), 567–574.
-
(1995)
Biochem. Pharmacol.
, vol.49
, Issue.4
, pp. 567-574
-
-
Smal, M.A.1
Dong, Z.2
Cheung, H.T.3
Asano, Y.4
Escoffier, L.5
Costello, M.6
Tattersall, M.H.7
-
6
-
-
15144346421
-
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance
-
[6] Jansen, G., Mauritz, R., Drori, S., Sprecher, H., Kathmann, I., Bunni, M., Priest, D.G., Noordhuis, P., Schornagel, J.H., Pinedo, H.M., Peters, G.J., Assaraf, Y.G., A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. J. Biol. Chem. 273:46 (1998), 30189–30198.
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.46
, pp. 30189-30198
-
-
Jansen, G.1
Mauritz, R.2
Drori, S.3
Sprecher, H.4
Kathmann, I.5
Bunni, M.6
Priest, D.G.7
Noordhuis, P.8
Schornagel, J.H.9
Pinedo, H.M.10
Peters, G.J.11
Assaraf, Y.G.12
-
7
-
-
84897476934
-
The effects of diosgenin in the regulation of renal proximal tubular fibrosis
-
[7] Wang, W.C., Liu, S.F., Chang, W.T., Shiue, Y.L., Hsieh, P.F., Hung, T.J., Hung, C.Y., Hung, Y.J., Chen, M.F., Yang, Y.L., The effects of diosgenin in the regulation of renal proximal tubular fibrosis. Exp. Cell Res. 323:2 (2014), 255–262.
-
(2014)
Exp. Cell Res.
, vol.323
, Issue.2
, pp. 255-262
-
-
Wang, W.C.1
Liu, S.F.2
Chang, W.T.3
Shiue, Y.L.4
Hsieh, P.F.5
Hung, T.J.6
Hung, C.Y.7
Hung, Y.J.8
Chen, M.F.9
Yang, Y.L.10
-
8
-
-
84868132557
-
Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin
-
[8] He, Z., Tian, Y., Zhang, X., Bing, B., Zhang, L., Wang, H., Zhao, W., Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin. Nat. Prod. Res. 26:23 (2012), 2243–2246.
-
(2012)
Nat. Prod. Res.
, vol.26
, Issue.23
, pp. 2243-2246
-
-
He, Z.1
Tian, Y.2
Zhang, X.3
Bing, B.4
Zhang, L.5
Wang, H.6
Zhao, W.7
-
9
-
-
84874968453
-
Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect
-
[9] Ghezali, L., Leger, D.Y., Limami, Y., Cook-Moreau, J., Beneytout, J.L., Liagre, B., Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect. Exp. Cell Res. 319:7 (2013), 1043–1053.
-
(2013)
Exp. Cell Res.
, vol.319
, Issue.7
, pp. 1043-1053
-
-
Ghezali, L.1
Leger, D.Y.2
Limami, Y.3
Cook-Moreau, J.4
Beneytout, J.L.5
Liagre, B.6
-
10
-
-
77950377691
-
Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells
-
[10] Lepage, C., Liagre, B., Cook-Moreau, J., Pinon, A., Beneytout, J.L., Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. Int. J. Oncol. 36:5 (2010), 1183–1191.
-
(2010)
Int. J. Oncol.
, vol.36
, Issue.5
, pp. 1183-1191
-
-
Lepage, C.1
Liagre, B.2
Cook-Moreau, J.3
Pinon, A.4
Beneytout, J.L.5
-
11
-
-
67650067290
-
Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells
-
[11] Srinivasan, S., Koduru, S., Kumar, R., Venguswamy, G., Kyprianou, N., Damodaran, C., Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Int. J. Cancer 125:4 (2009), 961–967.
-
(2009)
Int. J. Cancer
, vol.125
, Issue.4
, pp. 961-967
-
-
Srinivasan, S.1
Koduru, S.2
Kumar, R.3
Venguswamy, G.4
Kyprianou, N.5
Damodaran, C.6
-
12
-
-
0018745057
-
Studies on the disposition of diosgenin in rats, dogs, monkeys and man
-
[12] Cayen, M.N., Ferdinandi, E.S., Greselin, E., Dvornik, D., Studies on the disposition of diosgenin in rats, dogs, monkeys and man. Atherosclerosis 33:1 (1979), 71–87.
-
(1979)
Atherosclerosis
, vol.33
, Issue.1
, pp. 71-87
-
-
Cayen, M.N.1
Ferdinandi, E.S.2
Greselin, E.3
Dvornik, D.4
-
13
-
-
84863438515
-
Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment
-
[13] Kim, D.H., Hong, B.N., Le, H.T., Hong, H.N., Lim, C.W., Park, K.H., Kim, T.W., Kang, T.H., Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment. Bioorg. Med. Chem. Lett. 22:14 (2012), 4609–4612.
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, Issue.14
, pp. 4609-4612
-
-
Kim, D.H.1
Hong, B.N.2
Le, H.T.3
Hong, H.N.4
Lim, C.W.5
Park, K.H.6
Kim, T.W.7
Kang, T.H.8
-
14
-
-
84878776451
-
Synthesis of diosgenin-ibuprofen derivatives and their activities against insulin-dependent diabetes mellitus
-
[14] Xin, G., Wang, Y., Guo, X., Huang, B., Du, D., He, S., Zhang, R., Xing, Z., Zhao, H., Chen, Q., Huang, W., He, Y., Synthesis of diosgenin-ibuprofen derivatives and their activities against insulin-dependent diabetes mellitus. Chem. Pharm. Bull. 61:5 (2013), 532–538.
-
(2013)
Chem. Pharm. Bull.
, vol.61
, Issue.5
, pp. 532-538
-
-
Xin, G.1
Wang, Y.2
Guo, X.3
Huang, B.4
Du, D.5
He, S.6
Zhang, R.7
Xing, Z.8
Zhao, H.9
Chen, Q.10
Huang, W.11
He, Y.12
-
15
-
-
84870254697
-
Synthesis, characterization and biological studies of diosgenyl analogues
-
[15] Huang, B., Du, D., Zhang, R., Wu, X., Xing, Z., He, Y., Huang, W., Synthesis, characterization and biological studies of diosgenyl analogues. Bioorg. Med. Chem. Lett. 22:24 (2012), 7330–7334.
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, Issue.24
, pp. 7330-7334
-
-
Huang, B.1
Du, D.2
Zhang, R.3
Wu, X.4
Xing, Z.5
He, Y.6
Huang, W.7
-
16
-
-
84946210950
-
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease
-
[16] Chojnacki, J.E., Liu, K., Saathoff, J.M., Zhang, S., Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease. Bioorg. Med. Chem. 23:22 (2015), 7324–7331.
-
(2015)
Bioorg. Med. Chem.
, vol.23
, Issue.22
, pp. 7324-7331
-
-
Chojnacki, J.E.1
Liu, K.2
Saathoff, J.M.3
Zhang, S.4
-
17
-
-
35948935915
-
A facile approach to the preparation of bis-crown ethers based on SET-promoted photomacrocyclization reactions
-
[17] Sung, N.K., Cho, D.W., Choi, J.H., Choi, K.W., Yoon, U.C., Maeda, H., Mariano, P.S., A facile approach to the preparation of bis-crown ethers based on SET-promoted photomacrocyclization reactions. J. Org. Chem. 72:23 (2007), 8831–8837.
-
(2007)
J. Org. Chem.
, vol.72
, Issue.23
, pp. 8831-8837
-
-
Sung, N.K.1
Cho, D.W.2
Choi, J.H.3
Choi, K.W.4
Yoon, U.C.5
Maeda, H.6
Mariano, P.S.7
-
18
-
-
77956519419
-
Tricyclic host for linear anions
-
[18] Kang, S.O., Day, V.W., Bowman-James, K., Tricyclic host for linear anions. Inorg. Chem. 49:18 (2010), 8629–8636.
-
(2010)
Inorg. Chem.
, vol.49
, Issue.18
, pp. 8629-8636
-
-
Kang, S.O.1
Day, V.W.2
Bowman-James, K.3
-
19
-
-
84899005089
-
Solid-phase synthesis and hybrization behavior of partially 2′/3′-O-acetylated RNA oligonucleotides
-
[19] Xu, J., Duffy, C.D., Chan, C.K., Sutherland, J.D., Solid-phase synthesis and hybrization behavior of partially 2′/3′-O-acetylated RNA oligonucleotides. J. Org. Chem. 79:8 (2014), 3311–3326.
-
(2014)
J. Org. Chem.
, vol.79
, Issue.8
, pp. 3311-3326
-
-
Xu, J.1
Duffy, C.D.2
Chan, C.K.3
Sutherland, J.D.4
-
20
-
-
33845964502
-
Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs
-
[20] Santos, M.A., Enyedy, E.A., Nuti, E., Rossello, A., Krupenko, N.I., Krupenko, S.A., Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg. Med. Chem. 15:3 (2007), 1266–1274.
-
(2007)
Bioorg. Med. Chem.
, vol.15
, Issue.3
, pp. 1266-1274
-
-
Santos, M.A.1
Enyedy, E.A.2
Nuti, E.3
Rossello, A.4
Krupenko, N.I.5
Krupenko, S.A.6
-
21
-
-
30444448872
-
Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide
-
[21] Lindgren, M., Rosenthal-Aizman, K., Saar, K., Eiriksdottir, E., Jiang, Y., Sassian, M., Ostlund, P., Hallbrink, M., Langel, U., Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide. Biochem. Pharmacol. 71:4 (2006), 416–425.
-
(2006)
Biochem. Pharmacol.
, vol.71
, Issue.4
, pp. 416-425
-
-
Lindgren, M.1
Rosenthal-Aizman, K.2
Saar, K.3
Eiriksdottir, E.4
Jiang, Y.5
Sassian, M.6
Ostlund, P.7
Hallbrink, M.8
Langel, U.9
-
22
-
-
77955661190
-
Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cells
-
[22] Wu, Z., Shah, A., Patel, N., Yuan, X., Development of methotrexate proline prodrug to overcome resistance by MDA-MB-231 cells. Bioorg. Med. Chem. Lett. 20:17 (2010), 5108–5112.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.17
, pp. 5108-5112
-
-
Wu, Z.1
Shah, A.2
Patel, N.3
Yuan, X.4
-
23
-
-
0035955602
-
Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells
-
[23] Worm, J., Kirkin, A.F., Dzhandzhugazyan, K.N., Guldberg, P., Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells. J. Biol. Chem. 276:43 (2001), 39990–40000.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.43
, pp. 39990-40000
-
-
Worm, J.1
Kirkin, A.F.2
Dzhandzhugazyan, K.N.3
Guldberg, P.4
-
24
-
-
84906098500
-
Synthesis and in vitro evaluation of BBB permeability, tumor cell uptake, and cytotoxicity of a series of carboranylporphyrin conjugates
-
[24] Bhupathiraju, N.V., Hu, X., Zhou, Z., Fronczek, F.R., Couraud, P.O., Romero, I.A., Weksler, B., Vicente, M.G., Synthesis and in vitro evaluation of BBB permeability, tumor cell uptake, and cytotoxicity of a series of carboranylporphyrin conjugates. J. Med. Chem. 57:15 (2014), 6718–6728.
-
(2014)
J. Med. Chem.
, vol.57
, Issue.15
, pp. 6718-6728
-
-
Bhupathiraju, N.V.1
Hu, X.2
Zhou, Z.3
Fronczek, F.R.4
Couraud, P.O.5
Romero, I.A.6
Weksler, B.7
Vicente, M.G.8
-
25
-
-
84905197789
-
New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A
-
[25] Borrelli, S., Christodoulou, M.S., Ficarra, I., Silvani, A., Cappelletti, G., Cartelli, D., Damia, G., Ricci, F., Zucchetti, M., Dosio, F., Passarella, D., New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A. Eur. J. Med. Chem. 85 (2014), 179–190.
-
(2014)
Eur. J. Med. Chem.
, vol.85
, pp. 179-190
-
-
Borrelli, S.1
Christodoulou, M.S.2
Ficarra, I.3
Silvani, A.4
Cappelletti, G.5
Cartelli, D.6
Damia, G.7
Ricci, F.8
Zucchetti, M.9
Dosio, F.10
Passarella, D.11
-
26
-
-
84948798631
-
The rational design of a gemcitabine prodrug with AIE-based intracellular light-up characteristics for selective suppression of pancreatic cancer cells
-
[26] Han, H., Jin, Q., Wang, Y., Chen, Y., Ji, J., The rational design of a gemcitabine prodrug with AIE-based intracellular light-up characteristics for selective suppression of pancreatic cancer cells. Chem. Commun. 51:98 (2015), 17435–17438.
-
(2015)
Chem. Commun.
, vol.51
, Issue.98
, pp. 17435-17438
-
-
Han, H.1
Jin, Q.2
Wang, Y.3
Chen, Y.4
Ji, J.5
-
27
-
-
2442549560
-
Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling
-
[27] Pignatello, R., Guccione, S., Forte, S., Di Giacomo, C., Sorrenti, V., Vicari, L., Uccello Barretta, G., Balzano, F., Puglisi, G., Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling. Bioorg. Med. Chem. 12:11 (2004), 2951–2964.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, Issue.11
, pp. 2951-2964
-
-
Pignatello, R.1
Guccione, S.2
Forte, S.3
Di Giacomo, C.4
Sorrenti, V.5
Vicari, L.6
Uccello Barretta, G.7
Balzano, F.8
Puglisi, G.9
-
28
-
-
84862248921
-
Cancer cell signaling pathways targeted by spice-derived nutraceuticals
-
[28] Sung, B., Prasad, S., Yadav, V.R., Aggarwal, B.B., Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr. Cancer 64:2 (2012), 173–197.
-
(2012)
Nutr. Cancer
, vol.64
, Issue.2
, pp. 173-197
-
-
Sung, B.1
Prasad, S.2
Yadav, V.R.3
Aggarwal, B.B.4
|