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Bioorganic and Medicinal Chemistry

Volumn 23, Issue 22, 2015, Pages 7324-7331

Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease

(4) Chojnacki, Jeremy E a Liu, Kai a Saathoff, John M a Zhang, Shijun a

a VIRGINIA COMMONWEALTH UNIVERSITY (United States)

Author keywords

Alzheimer's disease; Bivalent strategy; Caprospinol; Curcumin; Diosgenin; Natural products

Indexed keywords

AMYLOID BETA PROTEIN; CAPROSPINOL; CARBON; CARBONYL DERIVATIVE; COPPER; CURCUMIN; DIOSGENIN; IRON; LIGAND; NATURAL PRODUCT; OLIGOMER; UNCLASSIFIED DRUG; ZINC; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; THIAZOLE DERIVATIVE; THIOFLAVINE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EC50; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROPROTECTION; PROTEIN BINDING; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; CELL SURVIVAL; CURCUMIN; DIOSGENIN; DRUG DESIGN; HUMANS; LIGANDS; NEUROPROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; THIAZOLES;

EID: 84946210950 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.10.032 Document Type: Article

Times cited : (31)

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