Synthesis and in vitro evaluation of BBB permeability, tumor cell uptake, and cytotoxicity of a series of carboranylporphyrin conjugates

Journal of Medicinal Chemistry

Volumn 57, Issue 15, 2014, Pages 6718-6728

  Bhupathiraju, N V S Dinesh K ^a   Hu, Xiaoke ^a   Zhou, Zehua ^a   Fronczek, Frank R ^a   Couraud, Pierre Olivier ^b   Romero, Ignacio A ^b   Weksler, Babette ^b   Vicente, M Graça H ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; ANTINEOPLASTIC AGENT; ARGININE; CARBORANYLPORPHYRIN; GLUCOSE; LUCIFER YELLOW; POLYAMINE; PORPHYRIN DERIVATIVE; TETRA[( 4 CARBORANYLMETHYLTHIO)TETRAFLUOROPHENYL]PORPHYRIN; TRIETHYLENE GLYCOL; TYROSYL DEXTRO ARGINYLPHENYLALANYL BETA ALANINE; UNCLASSIFIED DRUG; BORON DERIVATIVE; MACROGOL DERIVATIVE; OLIGOPEPTIDE; PHOTOSENSITIZING AGENT; PORPHYRIN; TYROSYL-ARGINYL-PHENYLALANYL-BETA--ALANINE;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CELL ORGANELLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG CONJUGATION; DRUG PENETRATION; DRUG SYNTHESIS; ENDOTHELIUM CELL; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROPHOBICITY; IC 50; IN VITRO STUDY; LYSOSOME; MITOCHONDRION; MOLECULAR WEIGHT; PHOTOTOXICITY; TUMOR CELL; CAPILLARY; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG SCREENING; METABOLISM; PERMEABILITY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; VASCULARIZATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; ARGININE; BLOOD-BRAIN BARRIER; BORON COMPOUNDS; BRAIN; CAPILLARIES; CELL LINE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOTHELIAL CELLS; GLUCOSE; HUMANS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; ORGANELLES; PERMEABILITY; PHOTOSENSITIZING AGENTS; POLYAMINES; POLYETHYLENE GLYCOLS; PORPHYRINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906098500     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500786c     Document Type: Article

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