Lipophilic conjugates of methotrexate with short-chain alkylamino acids as DHFR inhibitors. Synthesis, biological evaluation, and molecular modeling

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 11, 2004, Pages 2951-2964

  Pignatello, Rosario ^a   Guccione, Salvatore ^a   Forte, Stefano ^a   Di Giacomo, Claudia ^a   Sorrenti, Valeria ^a   Vicari, Luisa ^a   Barretta, Gloria Uccello ^b   Balzano, Federica ^b   Puglisi, Giovanni ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[N 1 (1 CARBOXYPROPYL) N 2 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](METHYL)AMINO]BENZOYL] ALPHA GLUTAMINYL]AMINO]BUTANOIC ACID; 2 [[N 1 (CARBOXYBUTYL) N 2 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](METHYL)AMINO]BENZOYL]AMINO]GLUTAMINYL]NORVALINATE; 2 [[N 1 (CARBOXYPENTYL) N 2 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](METHYL)AMINO]BENZOYL] ALPHA GLUTAMINYL]]NORLEUCINATE; BUTYRIC ACID DERIVATIVE; DIHYDROFOLATE REDUCTASE; HEXANOIC ACID DERIVATIVE; METHOTREXATE; METHYL 2 [[N 2 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](METHYL)AMINO]BENZOYL] N 1 [1 (METHOXYCARBONYL)BUTYL] ALPHA GLUTAMINYL]AMINO]PENTANOATE; METHYL 2 [[N 2 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](METHYL)AMINO]BENZOYL] N 1 [1 (METHOXYCARBONYL)PENTYL] ALPHA GLUTAMINYL]AMINO]HEXANOATE; METHYL 2 [[N 2 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](METHYL)AMINO]BENZOYL] N 1 [1 (METHOXYCARBONYL)PROPYL] ALPHA GLUTAMINYL]AMINO]BUTANOATE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MOLECULAR MODEL; PHYSICAL CHEMISTRY; STEREOCHEMISTRY;

AMINO ACIDS; ANIMALS; CATTLE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; LIPID METABOLISM; LIPIDS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; MODELS, MOLECULAR; STEREOISOMERISM; TETRAHYDROFOLATE DEHYDROGENASE;

BOVINAE;

EID: 2442549560     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.040     Document Type: Article

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