Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 3, 2007, Pages 1266-1274

  Santos, M Amélia ^a   Enyedy, Eva A ^a   Nuti, Elisa ^b   Rossello, Armando ^b   Krupenko, Natalia I ^c   Krupenko, Sergey A ^c  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b UNIVERSITY OF PISA   (Italy)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antifolates; DHFR inhibitors; Dual drugs; Methotrexate hydroxamate derivatives; MMP inhibitors

Indexed keywords

GELATINASE A; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENESIS; DRUG EFFECT; DRUG SYNTHESIS; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; METASTASIS;

CARCINOMA, NON-SMALL-CELL LUNG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASES; METHOTREXATE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 33845964502     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.11.017     Document Type: Article

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