Aging successfully needs lifelong prevention strategies

European Geriatric Medicine

Volumn 7, Issue 4, 2016, Pages 285-288

  Morley, J E ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging successfully; Disability; Frailty; Longevity; Prevention

Indexed keywords

CALCIUM; SODIUM; VITAMIN D; VITAMIN D BINDING PROTEIN;

AGING; ANEMIA; ANOREXIA; ATRIAL FIBRILLATION; BLOOD PRESSURE; BODY MASS; CALCIUM INTAKE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CONSTIPATION; CYANOCOBALAMIN DEFICIENCY; DEMENTIA; DEPRESSION; DIABETES MELLITUS; DISABILITY; EDITORIAL; EXERCISE; FAINTNESS; FALLING; HEALTH PROMOTION; HEART DISEASE; HUMAN; HYPERTENSION; HYPOTENSION; HYPOTHYROIDISM; LIFESPAN; MEDICAL SPECIALIST; MEDITERRANEAN DIET; MENTAL PERFORMANCE; MILD COGNITIVE IMPAIRMENT; NEPHROLITHIASIS; NURSING HOME; OSTEOPOROSIS; POLYPHARMACY; PRIMARY PREVENTION; PRIORITY JOURNAL; SARCOPENIA; SECONDARY PREVENTION; SLEEP DISORDERED BREATHING; SOCIALIZATION; SODIUM RESTRICTION; TERTIARY PREVENTION; VACCINATION; WEIGHT REDUCTION;

EID: 84992195890     PISSN: 18787649     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurger.2016.04.006     Document Type: Editorial

References (102)

1. [1] Michel, J.P., Dreux, C., Vacheron, A., Healthy ageing: evidence that Improvement is possible at every age. Eur Geriatr Med, 2016, 10.1016/j.eurger.2016.04.014.
2. [2] Sayer, A.A., Syddall, H.E., Gilbody, H.J., Dennison, E.M., Cooper, C., Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study. J Gerontol A Biol Sci Med Sci 59 (2004), M930–M934.
3. [3] Ma, X.M., Huang, Z.W., Yang, X.G., Su, Y.X., Calcium supplementation and bone mineral accretion in Chinese adolescents aged 12-14 years: a 12-month, dose-response, randomized intervention trial. Br J Nutr 112 (2014), 1510–1520.
4. A comprehensive meta-analysis on evidence of mediterranean diet and cardiovascular disease: are individual components equal?
5. [5] James, P.A., Oparil, S., Carter, B.L., Cushman, W.C., Dennison-Himmelfarb, C., Handler, J., et al. 2015 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311 (2014), 507–520.
6. [6] Sanford, A., Morley, J.E., Are the new guidelines for cholesterol and hypertension age friendly?. J Am Med Dir Assoc 15 (2014), 373–375.
7. [7] Cobb, J., Mitchell, M., Klaus-Peter, A., Nakhle, P., Button, E., Hathorn, J., et al. A novel fasting blood test for insulin resistance and prediabetes. J Diab Sci Technol 7 (2013), 100–110.
8. [8] Morley, J.E., Osteoporosis and fragility fractures. J Am Med Dir Assoc 12 (2011), 389–392.
9. [9] Chan, T.C., Hung, I.F., Chan, K.H., Li, C.P., Li, P.T., Luk, J.K., et al. Immunogenicity and safety of intradermal trivalent influenza vaccination in nursing home older adults: a randomized controlled trial. J Am Med Dir Assoc, 15, 2014 607.e5-e12.
10. [10] Lee, W.J., Chen, L.K., Tang, G.J., Lan, T.Y., The impact of influenza vaccination on hospitalizations and mortality among frail older people. J Am Med Dir Assoc 15 (2014), 256–260.
11. [11] Lang, P.O., Govind, S., Mitchell, W.A., Kenny, N., Lapenna, A., Pitts, D., et al. Influenza vaccine effectiveness in aged individuals: the role played by cell-mediated immunity. Eur Geriatr Med 1 (2010), 233–238.
12. [12] Wiwanitkit, V., How to increase seasonal influenza vaccine coverage. J Am Med Dir Assoc, 15, 2014, 296.
13. [13] Smith, K.J., Wateska, A.R., Nowalk, M.P., Raymund, M., Nuorti, J.P., Zimmerman, R.K., Cost-effectiveness of adult vaccination strategies using pneumococcal conjugate vaccine compared with pneumococcal polysaccharide vaccine. JAMA 307 (2012), 804–812.
14. [14] Morley, J.E., Treatment of hypertension in older persons: what is the evidence?. Drugs Aging 31 (2014), 331–337.
15. [15] Morley, J.E., Systolic hypertension should not be treated in persons aged 80 and older until blood pressure is greater than 160 mmHg. J Am Geriatr Soc 61 (2013), 1197–1198.
16. [16] Iwanczyk, L., Weintraub, N.T., Rubenstein, L.Z., Orthostatic hypotension in the nursing home setting. J Am Med Dir Assoc 7 (2006), 163–167.
17. [17] Trahair, L.G., Horowitz, M., Jones, K.L., Postprandial hypotension: a systematic review. J Am Med Dir Assoc 15 (2014), 394–409.
18. [18] Morley, J.E., Editorial:, Postprandial hypotension—the ultimate Big Mac attack. J Gerontol A Biol Sci Med Sci 56 (2001), M741–M743.
19. [19] Hui, D.S., Morley, J.E., Mikolajczak, P.C., Lee, R., Atrial fibrillation: a major risk factor for cognitive decline. Am Heart J 169 (2015), 448–456.
20. [20] Ampadu, J., Morley, J.E., Heart failure and cognitive dysfunction. Int J Cardiol 178 (2015), 12–23.
21. [21] Morley, J.E., Syncope. J Am Med Dir Assoc 14 (2013), 311–312.
22. [22] Jokanovic, N., Tan, E.C., Dooley, M.J., Kirkpatrick, C.M., Bell, J.S., Prevalence and factors associated with polypharmacy in long-term care facilities: a systematic review. J Am Med Dir Assoc, 16, 2015, 535 e1-e12.
23. [23] Moulis, F., Moulis, G., Balardy, L., Gerard, S., Sourdet, S., Rouge-Bugat, M.E., et al. Searching for a polypharmacy threshold associated with frailty. J Am Med Dir Assoc 16 (2015), 253–257.
24. [24] Morley, J.E., Inappropriate drug prescribing and polypharmacy are major causes of poor outcomes in long-term care. J Am Med Dir Assoc 15 (2014), 780–782.
25. [25] Fitzgerald, S.P., Bean, N.G., An analysis of the interactions between individual comorbidities and their treatments—implications for guidelines and polypharmacy. J Am Med Dir Assoc 11 (2010), 475–484.
26. [26] Little, M.O., Morley, J.E., Reducing polypharmacy: evidence from a simple quality improvement initiative. J Am Med Dir Assoc 14 (2013), 152–156.
27. [27] Moulis, F., Moulis, G., Balardy, L., Gerard, S., Montastruc, F., Sourdet, S., et al. Exposure to atropinic drugs and frailty status. J Am Med Dir Assoc 16 (2015), 253–257.
28. [28] Machado-Alba, J.E., Castro-Rodriguez, A., Alzate-Piedrahita, J.A., Hoyos-Pulgarin, J.A., Medina-Morales, D.A., Anticholinergic risk and frequency of anticholinergic drug prescriptions in a population older than 65. J Am Med Dir Assoc, 17, 2016 275e1-e4.
29. [29] Lowry, E., Woodman, R.J., Soiza, R.L., Mangoni, A.A., Associations between the anticholinergic risk scale score and physical function: potential implications for adverse outcomes in older hospitalized patients. J Am Med Dir Assoc 12 (2011), 565–572.
30. [30] O'Mahony, D., Gallagher, P., Ryan, C., Byrne, S., Hamilton, H., Barry, P., et al. STOPP & START criteria: a new approach to detecting potentially inappropriate prescribing in old age. Eur Ger Med 1 (2010), 45–51.
31. [31] Bales, C.W., Buhr, G., Is obesity bad for older persons? A systematic review of the pros and cons of weight reduction in later life. J Am Med Dir Assoc 9 (2008), 302–312.
32. [32] Morley, J.E., Pathophysiology of the anorexia of aging. Curr Opin Clin Nutr Metab Care 16 (2013), 27–32.
33. [33] Morley, J.E., Undernutrition in older adults. Fam Pract 29:Suppl. 1 (2012), i89–i93.
34. [34] Morley, J.E., Why have the complications of diabetes mellitus declined over the past 30 years?. J Am Med Dir Assoc 15 (2014), 449–453.
35. [35] Morley, J.E., Weight loss in older persons: new therapeutic approaches. Curr Pharm Des 13 (2007), 3637–3647.
36. [36] Villareal, D.T., Fontana, L., Das, S.K., Redman, L., Smith, S.R., Saltzman, E., et al. Effect of two-year caloric restriction on bone metabolism and bone mineral density in non-obese younger adults: a randomized clinical trial. J Bone Miner Res 31 (2016), 40–51.
37. [37] Soenen, S., Chapman, I.M., Body weight, anorexia, and undernutrition in older people. J Am Med Dir Assoc 14 (2013), 642–648.
38. [38] Morley, J.E., Anorexia of aging: physiologic and pathologic. Am J Clin Nutr 66 (1997), 760–773.
39. [39] Ezeoke, C.C., Morley, J.E., Pathophysiology of anorexia in the cancer cachexia syndrome. J Cachexia Sarcopenia Muscle 6 (2015), 287–302.
40. [40] Thomas, D.R., Kamel, H., Azharrudin, M., Ali, A.S., Khan, A., Javaid, U., et al. The relationship of functional status, nutritional assessment, and severity of illness to in-hospital mortality. J Nutr Health Aging 9 (2005), 169–175.
41. [41] O'Donnell, M., Mente, A., Rangarajan, S., McQueen, M.J., Wang, X., Liu, L., et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med 371 (2014), 612–623.
42. [42] Stolarz-Skrzypek, K., Kuznetsova, T., Thijs, L., Tikhonoff, V., Seidlerova, J., Richart, T., et al. European Project on Genes in Hypertension (EPOGH) Investigators. Fata and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion. JAMA 305 (2011), 1777–1785.
43. [43] Morley, J.E., Osteoporosis: new treatments. J Am Med Dir Assoc 16 (2015), 265–267.
44. [44] Morley, J.E., Dementia:, Does vitamin D modulate cognition?. Nat Rev Neurol 10 (2014), 613–614.
45. [45] Rosen, C.J., Clinical, practice., Vitamin D insufficiency. N Engl J Med 364 (2011), 248–254.
46. [46] Hoofnagle, A.N., Eckfeldt, J.H., Lutsey, P.L., Vitamin D-binding protein concentrations quantified by mass spectrometry. N Engl J Med 373 (2015), 1480–1482.
47. [47] Morley, J.E., Vellas, B., van Kan, G.A., Anker, S.D., Bauer, J.M., Bernabei, R., et al. Frailty consensus: a call to action. J Am Med Dir Assoc 14 (2013), 392–397.
48. [48] Morley, J.E., Frailty: a time for action. Eur Geriatr Med 4 (2013), 215–216.
49. [49] Morley, J.E., von Haehling, S., Anker, S.D., Vellas, B., From sarcopenia to frailty: a road less traveled. J Cachexia Sarcopenia Muscle 5 (2014), 5–8.
50. [50] Malmstrom, T.K., Miller, D.K., Morley, J.E., A comparison of four frailty models. J Am Geriatr Soc 62 (2014), 721–726.
51. [51] Morley, J.E., Malmstrom, T.K., Miller, D.K., A simple frailty questionnaire (FRAIL) predicts outcomes in middle-aged African Americans. J Nutr Health Aging 16 (2012), 601–608.
52. [52] Woo, J., Leung, J., Morley, J.E., Comparison of frailty indicators based on clinical phenotype and the multiple deficit approach in predicting mortality and physical limitation. J Am Geriatr Soc 60 (2012), 1478–1486.
53. [53] Hyde, Z., Flicker, L., Almeida, O.P., Hankey, G.J., McCaul, K.A., Chubb, S.A., et al. Low free testosterone predicts frailty in older men: the health in men study. J Clin Endocrinol Metab 95 (2010), 3165–3172.
54. [54] Gardiner, P.A., Mishra, G.D., Dobson, A.J., Validity and responsiveness of the FRAIL scale in a longitudinal cohort study of older Australian women. J Am Med Dir Assoc 16 (2015), 781–783.
55. [55] Woo, J., Leung, J., Morley, J.E., Defining sarcopenia in terms of incident adverse outcomes. J Am Med Dir Assoc 16 (2015), 247–252.
56. [56] Woo, J., Leung, J., Morley, J.E., Validating the SARC-F: a suitable community screening tool for sarcopenia?. J Am Med Dir Assoc 15 (2014), 630–634.
57. [57] Cao, L., Chen, S., Zou, C., Ding, X., Gao, L., Liao, Z., et al. A pilot study of the SARC-F scale on screening sarcopenia and physical disability in the Chinese older people. J Nutr Health Aging 18 (2014), 277–283.
58. [58] Malmstrom, T.K., Morley, J.E., SARC-F: a simple questionnaire to rapidly diagnose sarcopenia. J Am Med Dir Assoc 14 (2013), 531–532.
59. [59] Morley, J.E., Cao, L., Rapid screening for sarcopenia. J Cachexia Sarcopenia Muscle 6 (2015), 312–314.
60. [60] Bauer, J.M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L.M., Maggio, M., et al. Effects of vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 16 (2015), 740–747.
61. [61] Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A.J., Morley, J.E., et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE study group. J Am Med Dir Assoc 14 (2013), 542–559.
62. [62] Morley, J.E., Abbatecola, A.M., Argiles, J.M., Baracos, V., Bauer, J., Cederholm, T., et al. Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop. Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 12 (2011), 403–409.
63. [63] Churchward-Venne, T.A., tiland, M., Verdijk, L.B., Leenders, M., Dirks, M.L., de Groot, L.C., et al. There are no nonresponders to resistance-type exercise training in older men and women. J Am Med Dir Assoc 16 (2015), 400–411.
64. [64] Morley, J.E., Argiles, J.M., Evans, W.J., Bhasin, S., Cella, D., Deutz, N.E., et al. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 11 (2010), 391–396.
65. [65] Tarazona-Santabalbina, F.J., Gomez-Cabrera, M.C., Perez-Ros, P., Martinez-Arnau, F.M., Cabo, H., Tsaparas, K., et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: a randomized clinical trial. J Am Med Dir Assoc, 2016, 17, 10.1016/j.jamda.2016.01.019 [Epub ahead of print].
66. [66] Abizanda, P., Lopez, M.D., Garcia, V.P., Estrella Jde, D., da Silva Gonzalez, A., Vilardell, N.B., et al. Effects of an oral nutritional supplementation plus physical exercise intervention on the physical function, nutritional status, and quality of life in frail institutionalized older adults: the ACTIVNES study. J Am Med Dir Assoc 16 (2015), 439e9–439e16.
67. [67] Ng, T.P., Feng, L., Nyunt, M.S., Feng, L., Niti, M., Tan, B.Y., et al. Nutritional, physical, cognitive, and combination interventions and frailty reversal among older adults: a randomized controlled trial. Am J Med, 128, 2015 1225-1236.e1.
68. [68] Morley, J.E., Depression in nursing home residents. J Am Med Dir Assoc 11 (2010), 301–303.
69. [69] Thakur, M., Blazer, D.G., Depression in long-term care. J Am Med Dir Assoc 9 (2008), 82–87.
70. [70] Onen, F., Higgins, S., Onen, S.H., Falling-asleep-related injured falls in the elderly. J Am Med Dir Assoc 10 (2009), 207–210.
71. [71] Ferrè, A., Chronic fatigue syndrome and sleep disorders: clinical associations and diagnostic difficulties. Neurologia, 2016, 10.1016/j.nrl.2015.11.019 [Epub ahead of print].
72. [72] Kaltsas, G., Fgontzas, A., Chrousos, G., Fatigue, endocrinopathies, and metabolic disorders. PM R 2 (2010), 393–398.
73. [73] Briani, C., Dalla Torre, C., Citton, V., Manara, R., Pompanin, S., Binotto, G., et al. Cobalimin deficiency: clinical picture and radiological findings. Nutrients 5 (2013), 4521–4539.
74. [74] Artz, A.S., Anemia and the frail elderly. Semin Hematol 45 (2008), 261–266.
75. [75] Morley, J.E., Anorexia of aging: a true geriatric syndrome. J Nutr Health Aging 16 (2012), 422–425.
76. [76] Morley, J.E., Silver, A.J., Nutritional issues in nursing home care. Ann Intern Med 123 (1995), 850–859.
77. [77] Leon-Munoz, L.M., Guallar-Castillon, P., Lopez-Garcia, E., Rodriguez-Artalejo, F., Mediterranean diet and risk of frailty in community-dwelling older adults. J Am Med Dir Assoc 15 (2014), 899–903.
78. [78] Jansen, S., Bhangu, J., de Rooij, S., Daams, J., Kenny, R.A., van der Velde, N., The association of cardiovascular disorders and falls: a systematic review. J Am Med Dir Assoc 17 (2016), 193–199.
79. [79] Day, L., Hill, K.D., Stathakis, V.Z., Flicker, L., Segal, L., Cicuttini, F., et al. Impact of tai-chi on falls among preclinically disabled older people. A randomized controlled trial. J Am Med Dir Assoc 16 (2015), 420–426.
80. [80] Büchele, G., Becker, C., Cameron, I.D., König, H.H., Robinovitch, S., Rapp, K., Predictors of serious consequences of falls in residential aged care: analysis of more than 70,000 falls from residents of Bavarian nursing homes. J Am Med Dir Assoc 15 (2014), 559–563.
81. [81] Morley, J.E., Is it possible to prevent injurious falls?. Eur Geriatr Med 5 (2014), 75–77.
82. [82] Silva, R.B., Eslick, G.D., Duque, G., Exercise for falls and fracture prevention in long term care facilities: a systematic review and meta-analysis. J Am Med Dir Assoc, 14, 2013 685-689.e2.
83. [83] Morley, J.E., Frailty, falls, and fractures. J Am Med Dir Assoc 14 (2013), 149–151.
84. [84] Nyrop, K.A., Zimmerman, S., Sloane, P.D., Bangdiwala, S., Fall prevention and monitoring of assisted living patients: an exploratory study of physician perspectives. J Am Med Dir Assoc 13 (2012), 429–433.
85. [85] Morley, J.E., Morris, J.C., Berg-Weger, M., Borson, S., Carpenter, B.D., Del Campo, N., et al. Brain health: the importance of recognizing cognitive impairment: an IAGG consensus conference. J Am Med Dir Assoc 16 (2015), 731–739.
86. [86] Wimo, A., Winblad, B., Brain health: a primary health care viewpoint. J Am Med Dir Assoc 16 (2015), 720–721.
87. [87] Malmstrom, T.K., Voss, V.B., Cruz-Oliver, D.M., Cummings-Vaughn, L.A., Tumosa, N., Grossberg, G.T., et al. The Rapid Cognitive Screen (RCS): a point-of-care screening for dementia and mild cognitive impairment. J Nutr Health Aging 7 (2015), 741–744.
88. [88] Sakurai, T., Arai, H., Toba, K., Japan's challenge of early detection of persons with cognitive decline. J Am Med Dir Assoc, 7, 2016, 10.1016/j.jamda.2016.02.012 [Epub ahead of print].
89. [89] Lam, L.C., Chau, R.C., Wong, B.M., Fung, A.W., Tam, C.W., Leung, G.T., et al. A 1-year randomized controlled trial comparing mind body exercise (Tai Chi) with stretching and toning exercise on cognitive function in older Chinese adults at risk of cognitive decline. J Am Med Dir Assoc, 24, 2012 568.e15-20.
90. [90] Fiatarone Singh, M.A., Gates, N., Saigal, N., Wilson, G.C., Meiklejohn, J., Brodaty, H., et al. The study of mental and resistance training (SMART) study—resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial. J Am Med Dir Assoc 15 (2014), 873–880.
91. [91] Komulainen, P., Kivipelto, M., Lakka, T.A., Savonen, K., Hassinen, M., Kiviniemi, V., et al. Exercise, fitness and cognition–a randomized controlled trial in older individuals: the DR's EXTRA Study. Eur Geriatr Med 1 (2010), 266–272.
92. [92] Ströhle, A., Schmidt, D.K., Schultz, F., Fricke, N., Staden, T., Hellweg, R., et al. Drug and exercise treatment of Alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis of effects on cognition in randomized controlled trials. Am J Geriatr Psychiatry 23 (2015), 1234–1249.
93. [93] Martinez-Lapiscina, E.H., Clavero, P., Toledo, E., San Julian, B., Sanchex-Tainta, A., Corella, D., et al. Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized trial. J Nutr Health Aging 17 (2013), 544–552.
94. [94] Martinez-Lapiscina Eh, Clavero, P., Toledo, E., Estruch, R., Salas-Salvado, J., San Julian, J., et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRO randomized trial. J Neurol Neurosurg Psychiatry 84 (2013), 1318–1325.
95. [95] Farr, S.A., Price, T.O., Dominguez, L.J., Motisi, A., Saiano, F., Niehoff, M.L., et al. Extra virgin olive oil improves learning and memory in SAMP8 mice. J Alzheimers Dis 28 (2012), 81–92.
96. [96] Wells, J.L., Seabrook, J.A., Stolee, P., Borrie, M.J., Knoefel, F., State of the art in geriatric rehabilitation. Part 1: review of frailty and comprehensive geriatric assessment. Arch Phys Med Rehabil 84 (2003), 890–897.
97. [97] Van Craen, K., Braes, T., Wellens, N., Denhaerynck, K., Flamaing, J., Moons, P., et al. The effectiveness of inpatient geriatric evaluation and management units: a systematic review and meta-analysis. J Am Geriatr Soc 58 (2010), 83–92.
98. [98] Kaehr, E.W., Pape, L.C., Malmstrom, T.K., Morley, J.E., FRAIL-NH predicts outcomes in long term care. J Nutr Health Aging 20 (2016), 192–198.
99. [99] Kaehr, E., Visvanathan, R., Malmstrom, T.K., Morley, J.E., Frailty in nursing homes: the FRAIL-NH scale. J Am Med Dir Assoc 16 (2015), 87–89.
100. [100] Luo, H., Lum, T.Y., Wong, G.H., Kwan, J.S., Tang, J.Y., Chi, I., Predicting adverse health outcomes in nursing homes: a 9-year longitudinal study and development of the FRAIL-Minimum Data Set (MDS) quick screening tool. J Am Med Dir Assoc 16 (2015), 1042–1047.
101. [101] Morley, J.E., Aging successfully: the key to aging in place. J Am Med Dir Assoc 16 (2015), 1005–1007.
102. [102] Young, Y., Fan, M.Y., Parrish, J.M., Frick, K.D., Validation of a novel successful aging construct. J Am Med Dir Assoc 10 (2009), 314–322.