Anticholinergic Risk and Frequency of Anticholinergic Drug Prescriptions in a Population Older Than 65

Journal of the American Medical Directors Association

Volumn 17, Issue 3, 2016, Pages 275.e1-275.e4

  Machado Alba, Jorge Enrique ^a   Castro Rodríguez, Alejandro ^b   Álzate Piedrahita, John Alexander ^a   Hoyos Pulgarín, Julián Andrés ^a   Medina Morales, Diego Alejandro ^a  

^a UNIVERSIDAD TECNOLÓGICA DE PEREIRA   (Colombia)

^b UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

Aged 80 and older; Cholinergic antagonists; Health services; Pharmacoepidemiology (MeSH); Prescription drugs

Indexed keywords

CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; LORATADINE; METHOCARBAMOL; RANITIDINE; SCOPOLAMINE BUTYL BROMIDE; TRAZODONE;

AGED; ARTICLE; COLOMBIA; CROSS-SECTIONAL STUDY; FEMALE; GERIATRIC PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRESCRIPTION; INAPPROPRIATE PRESCRIBING; POLYPHARMACY; RISK ASSESSMENT; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CHOLINERGIC ANTAGONISTS; COLOMBIA; CROSS-SECTIONAL STUDIES; DRUG PRESCRIPTIONS; FEMALE; HUMANS; INAPPROPRIATE PRESCRIBING; MALE; POLYPHARMACY; RISK ASSESSMENT;

EID: 84958922717     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2015.12.003     Document Type: Article

References (23)

1. Rudolph J.L., Salow M.J., Angelini M.C., McGlinchey R.E. The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med 2008, 168:508-513.
2. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012, 60:616-631.
3. Lam M.P., Cheung B.M. The use of STOPP/START criteria as a screening tool for assessing the appropriateness of medications in the elderly population. Expert Rev Clin Pharmacol 2012, 5:187-197.
4. Kachru N., Carnahan R.M., Johnson M.L., Aparasu R.R. Potentially inappropriate anticholinergic medication use in community-dwelling older adults: A national cross-sectional study. Drugs Aging 2015, 32:379-389.
5. Willcox S.M., Himmelstein D.U., Woolhandler S. Inappropriate drug prescribing for the community-dwelling elderly. JAMA 1994, 272:292-296.
6. Lane C.J., Bronskill S.E., Sykora K., et al. Potentially inappropriate prescribing in Ontario community-dwelling older adults and nursing home residents. J Am Geriatr Soc 2004, 52:861-866.
7. López-Álvarez J., Sevilla M.A.Z., Ortiz L.A., et al. Efecto de los fármacos anticolinérgicos en el rendimiento cognitivo de las personas mayores. Rev Psiquiatr Salud Ment 2015, 8:35-43.
8. Ruxton K., Woodman R.J., Mangoni A.A. Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis. Br J Clin Pharmacol 2015, 80:209-220.
9. Arango V, Ruiz I. Diagnóstico de los adultos mayores de Colombia. Bogotá, Columbia: Documento de investigación de la Fundación Saldarriaga Concha Bogotá 2006.
10. Pasina L., Djade C.D., Lucca U., et al. Association of anticholinergic burden with cognitive and functional status in a cohort of hospitalized elderly: Comparison of the anticholinergic cognitive burden scale and anticholinergic risk scale: Results from the REPOSI study. Drugs Aging 2013, 30:103-112.
11. Lu W.H., Wen Y.W., Chen L.K., Hsiao F.Y. Effect of polypharmacy, potentially inappropriate medications and anticholinergic burden on clinical outcomes: a retrospective cohort study. CMAJ 2015, 187:E130-E137.
12. Narayan S.W., Hilmer S.N., Horsburgh S., Nishtala P.S. Anticholinergic component of the drug Burden Index and the anticholinergic drug scale as measures of anticholinergic exposure in older people in New Zealand: A population-level study. Drugs Aging 2013, 30:927-934.
13. Departamento Administrativo Nacionales de Estadistica (DANE). Demografía y población/Estimaciones y proyecciones de población/Estimación y proyección de población nacional, departamental y municipal por sexo, grupos quinquenales de edad y edades simples de 0 a 26 años 1985-2020. Columbia: Departamento Administrativo Nacionales de Estadistica (DANE); 2015.
14. Departamento Administrativo Nacionales de Estadistica (DANE). Estadísticas vitales/Defunciones no fetales 2014/Defunciones por área donde ocurrió la defunción y sexo, según grupos de edad. Total nacional. Columbia: Departamento Administrativo Nacionales de Estadistica (DANE); 2015.
15. Lowry E., Woodman R.J., Soiza R.L., Mangoni A.A. Associations between the anticholinergic risk scale score and physical function: Potential implications for adverse outcomes in older hospitalized patients. J Am Med Dir Assoc 2011, 12:565-572.
16. Salahudeen M.S., Hilmer S.N., Nishtala P.S. Comparison of anticholinergic risk scales and associations with adverse health outcomes in older people. J Am Geriatr Soc 2015, 63:85-90.
17. Curtis L.H., Ostbye T., Sendersky V., et al. Inappropriate prescribing for elderly Americans in a large outpatient population. Arch Intern Med 2004, 164:1621-1625.
18. Machado-Alba J.E., Plaza C.M., Gómez M.S. Patrones de prescripción de antidepresivos en pacientes afiliados al Sistema General de Seguridad Social en Salud de Colombia. Rev Panam Salud Pública 2011, 30:461.
19. Holguín E., Orozco J.G. Medicación potencialmente inapropiada en ancianos en un hospital de cuarto nivel en Bogotá. Universitas Médica 2011, 52:149-168.
20. Berdot S., Bertrand M., Dartigues J.F., et al. Inappropriate medication use and risk of falls-a prospective study in a large community-dwelling elderly cohort. BMC Geriatr 2009, 9:30.
21. Cid-Ruzafa J., Damián-Moreno J. Valoración de la discapacidad física: El índice de barthel. Rev Esp Salud Publica 1997, 71:127-137.
22. Campbell N., Boustani M., Limbil T., et al. The cognitive impact of anticholinergics: A clinical review. Clin Interv Aging 2009, 4:225-233.
23. Mangoni A.A., van Munster B.C., Woodman R.J., de Rooij S.E. Measures of anticholinergic drug exposure, serum anticholinergic activity, and all-cause postdischarge mortality in older hospitalized patients with hip fractures. Am J Geriatr Psychiatry 2013, 21:785-793.