Exercise, fitness and cognition - A randomised controlled trial in older individuals: The DR's EXTRA study

European Geriatric Medicine

Volumn 1, Issue 5, 2010, Pages 266-272

  Komulainen, P ^a   Kivipelto, M ^a,b   Lakka, T A ^a   Savonen, K ^a,c   Hassinen, M ^a   Kiviniemi, V ^a   Hanninen T ^c   Rauramaa, R ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Ageing; Cognitive function; Memory; Physical exercise; Randomised controlled trial

Indexed keywords

ADULT; AEROBIC EXERCISE; AGED; ANGINA PECTORIS; ARTICLE; BICYCLE ERGOMETRY; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DISEASE COURSE; DIZZINESS; EXERCISE; FEMALE; FITNESS; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MUSCLE TRAINING; NEUROPSYCHOLOGICAL TEST; OXYGEN CONSUMPTION; POPULATION; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; RISK FACTOR; SEX DIFFERENCE; VERBAL BEHAVIOR;

EID: 78049431659     PISSN: 18787649     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurger.2010.08.001     Document Type: Article

References (30)

1. P.J. Nestor, P. Scheltens, and J.R. Hodges Advances in the early detection of Alzheimer's disease Nat Med 5 Suppl. 2004 S34 S41
2. J. Weuve, J.H. Kang, and J.E. Manson Physical activity, including walking, and cognitive function in older women JAMA 292 2004 1454 1461
3. D. Laurin, R. Verreault, and J. Lindsay Physical activity and risk of cognitive impairment and dementia in elderly persons Arch Neurol 58 2001 498 504 (Pubitemid 32217469)
4. K. Yaffe, D. Barnes, and M. Nevitt A prospective study of physical activity and cognitive decline in elderly women: women who walk Arch Intern Med 161 2001 1703 1708
5. R.D. Abbott, L.R. White, and G.W. Ross Walking and dementia in physically capable elderly men JAMA 292 2004 1447 1453
6. S. Rovio, I. Kareholt, and E.L. Helkala Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease Lancet Neurol 4 2005 705 711 (Pubitemid 41457285)
7. E.B. Larson, L. Wang, and J.D. Bowen Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older Ann Intern Med 144 2006 73 81
8. M. Angevaren, G. Aufdemkampe, and H.J. Verhaar Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment Cochrane Database Syst Rev 16 2008 CD005381
9. Daviglus ML, Bell CC, Berrettini W, et al. NIH State-of-the-Science Conference Statement: preventing Alzheimer's disease and cognitive decline. NIH Consens State Sci Statements 2010;27:1-19 [Epub ahead of print].
10. N.T. Lautenschlager, K.L. Cox, and L. Flicker Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial JAMA 300 2008 1027 1037
11. T. Liu-Ambrose, L.S. Nagamatsu, and P. Graf Resistance training and executive functions: a 12-month randomized controlled trial Arch Intern Med 170 2010 170 178
12. US Department of Health and Human Services. Physical Activity and Health: a report of the surgeon general. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, 1996.
13. J. Morris, A. Heyman, and R. Mohs The Consortium to establish a registry for Alzheimer's disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease Neurology 39 1989 1159 1165
14. T.A. Lakka, D.E. Laaksonen, and H.M. Lakka Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome Med Sci Sports Exerc 35 2003 1279 1286
15. M. Hassinen, T.A. Lakka, and K. Savonen Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women: the dose-responses to exercise training study (DR's Extra) Diabetes Care 31 2008 1242 1247
16. P. Komulainen, M. Pedersen, and T. Hanninen BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study Neurobiol Learn Mem 90 2008 596 603
17. L.S. Radloff The CES-D scale: a self-report depression scale for research in the general population Appl Psychol Meas 1 1977 385 401
18. M.E. Nelson, W.J. Rejeski, and S.N. Blair Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association Circulation 116 2007 1094 1105
19. C. Bouchard, and T. Rankinen Individual differences in response to regular physical activity Med Sci Sports Exerc 33 2001 S446 S451
20. T.A. Lakka, J.M. Venalainen, and R. Rauramaa Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction N Engl J Med 330 1994 1549 1554
21. L. Fratiglioni, S. Paillard-Borg, and B. Winblad An active and socially integrated lifestyle in late life might protect against dementia Lancet Neurol 3 2004 343 353
22. S.J. Colcombe, K.I. Erickson, and N. Raz Aerobic fitness reduces brain tissue loss in aging humans J Gerontol A Biol Sci Med Sci 58 2003 176 180
23. B. Winter, C. Breitenstein, and F.C. Mooren High impact running improves learning Neurobiol Learn Mem 87 2007 597 609
24. M.G. Murer, Q. Yan, and R. Raisman-Vozari Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease Prog Neurobiol 63 2001 71 124
25. K.S. Krabbe, A.R. Nielsen, and R. Krogh-Madsen Brain-derived neurotrophic factor (BDNF) and type 2 diabetes Diabetologia 50 2007 431 438
26. C.H. Hillman, K.I. Erickson, and A.F. Kramer Be smart, exercise your heart: exercise effects on brain and cognition Nat Rev Neurosci 9 2008 58 65
27. S. Colcombe, and A.F. Kramer Fitness effects on the cognitive function of older adults: a meta-analytic study Psychol Sci 14 2003 125 130 (Pubitemid 37283096)
28. O. Lazarov, J. Robinson, and Y.P. Tang Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice Cell 120 2005 701 713
29. D.E. Barnes, K. Yaffe, and W.A. Satariano A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults J Am Geriatr Soc 51 2003 459 465
30. G.C. Roman, P. Sachdev, and D.R. Royall Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia J Neurol Sci 226 2004 81 87