IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors

ACS Chemical Biology

Volumn 11, Issue 10, 2016, Pages 2693-2705

  Cousido Siah, Alexandra ^a   Ruiz, Francesc X ^a,c   Fanfrlík, Jindřich ^b   Giménez Dejoz, Joan ^c   Mitschler, André ^a   Kamlar, Martin ^d   Veselý, Jan ^d   Ajani, Haresh ^b,e   Parés, Xavier ^c   Farrés, Jaume ^c   Hobza, Pavel ^b,e   Podjarny, Alberto D ^a  

^a CNRS   (France)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d CHARLES UNIVERSITY   (Czech Republic)

^e PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; POLYHALO DERIVATIVE; AKR1B10 PROTEIN, HUMAN; HALOGEN; MOLECULAR PROBE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; IC50; IN VITRO STUDY; MASS SPECTROMETRY; PRACTICE GUIDELINE; PRIORITY JOURNAL; SOLVATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; MOLECULAR PROBE;

ALDEHYDE REDUCTASE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HALOGENS; MOLECULAR PROBES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84992188326     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.6b00382     Document Type: Article

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