The Alrestatin double-decker: Binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant

Biochemistry

Volumn 36, Issue 51, 1997, Pages 16134-16140

  Harrison, David H T ^a,c   Bohren, Kurt M ^b   Petsko, Gregory A ^a   Ringe, Dagmar ^a   Gabbay, Kenneth H ^b  

^a BRANDEIS UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ALRESTATIN; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SPECIFICITY; PRIORITY JOURNAL;

ALDEHYDE REDUCTASE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; ISOQUINOLINES; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NADP; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0031424157     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9717136     Document Type: Article

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