The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

ACS Chemical Biology

Volumn 10, Issue 7, 2015, Pages 1637-1642

  Fanfrlík, Jindřich ^a   Ruiz, Francesc X ^b   Kadlčíková, Aneta ^a   Řezáč, Jan ^a   Cousido Siah, Alexandra ^b   Mitschler, André ^b   Haldar, Susanta ^a   Lepšík, Martin ^a   Kolář, Michal H ^a,c   Majer, Pavel ^a   Podjarny, Alberto D ^b   Hobza, Pavel ^a,d  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

AK 198; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; AMINE; BROMINE; HALOGEN; HYDROGEN; IDD 388; IODINE; MK 315; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

ARTICLE; ATOM; DRUG CONFORMATION; ENERGY TRANSFER; ENZYME INHIBITION; HALOGEN TO HYDROGEN BOND SUBSTITUTION; HUMAN; IC50; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HALOGENATION; HYDROGEN BOND; METABOLISM;

ALDEHYDE REDUCTASE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HALOGENATION; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR;

EID: 84937120472     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00151     Document Type: Article

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