메뉴 건너뛰기




Volumn 4, Issue , 2016, Pages

Vitamin D, calcium homeostasis and aging

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLENE 19 NOR 1ALPHA 25 DIHYDROXYVITAMIN D3; ALFACALCIDOL; CALCIUM; ELDECALCITOL; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D DERIVATIVE;

EID: 84992166495     PISSN: 20954700     EISSN: 20956231     Source Type: Journal    
DOI: 10.1038/boneres.2016.41     Document Type: Review
Times cited : (276)

References (79)
  • 1
    • 76149097543 scopus 로고    scopus 로고
    • Calcium metabolism in health and disease
    • Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol 2010; 5 (Suppl 1): S23-S30.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. S23-S30
    • Peacock, M.1
  • 2
    • 0026355278 scopus 로고
    • Calcium absorption in normal and osteoporotic postmenopausal women
    • Morris HA, Need AG, Horowitz M et al. Calcium absorption in normal and osteoporotic postmenopausal women. Calcif Tissue Int 1991; 49: 240-243.
    • (1991) Calcif Tissue Int , vol.49 , pp. 240-243
    • Morris, H.A.1    Need, A.G.2    Horowitz, M.3
  • 3
    • 0034095006 scopus 로고    scopus 로고
    • Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Study of Osteoporotic Fractures Research Group
    • Ensrud KE, Duong T, Cauley JA et al. Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Study of Osteoporotic Fractures Research Group. Ann Intern Med 2000; 132: 345-353.
    • (2000) Ann Intern Med , vol.132 , pp. 345-353
    • Ensrud, K.E.1    Duong, T.2    Cauley, J.A.3
  • 4
    • 84861578479 scopus 로고    scopus 로고
    • Recent advances in our understanding of 1,25-dihydroxy Vitamin D(3) regulation of intestinal calcium absorption
    • Christakos S. Recent advances in our understanding of 1,25-dihydroxy Vitamin D(3) regulation of intestinal calcium absorption. Arch Biochem Biophys 2012; 523: 73-76.
    • (2012) Arch Biochem Biophys , vol.523 , pp. 73-76
    • Christakos, S.1
  • 5
    • 38849145209 scopus 로고    scopus 로고
    • The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics
    • Brown EM. The calcium-sensing receptor: physiology, pathophysiology and CaR-based therapeutics. Subcell Biochem 2007; 45: 139-167.
    • (2007) Subcell Biochem , vol.45 , pp. 139-167
    • Brown, E.M.1
  • 6
    • 78649697894 scopus 로고    scopus 로고
    • Vitamin D, disease and therapeutic opportunities
    • Plum LA, De Luca HF. Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov 2010; 9: 941-955.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 941-955
    • Plum, L.A.1    De Luca, H.F.2
  • 7
    • 85009848202 scopus 로고    scopus 로고
    • Vitamin D: Production, metabolism and clinical requirements
    • Hoboken: John Wiley and Sons
    • Bikle DD, Adams J, Christakos S. Vitamin D: production, metabolism and clinical requirements//Rosen C. Primer on Metabolic Bone Diseases. Hoboken: John Wiley and Sons, 2013: 235-245.
    • (2013) Rosen C. Primer on Metabolic Bone Diseases , pp. 235-245
    • Bikle, D.D.1    Adams, J.2    Christakos, S.3
  • 8
    • 84862808037 scopus 로고    scopus 로고
    • Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?
    • Zhu J, De Luca HF. Vitamin D 25-hydroxylase - four decades of searching, are we there yet? Arch Biochem Biophys 2012; 523: 30-36.
    • (2012) Arch Biochem Biophys , vol.523 , pp. 30-36
    • Zhu, J.1    De Luca, H.F.2
  • 9
    • 0141732321 scopus 로고    scopus 로고
    • De-orphanization of cytochrome P450 2R1: A microsomal Vitamin D 25-hydroxylase
    • Cheng JB, Motola DL, Mangelsdorf DJ et al. De-orphanization of cytochrome P450 2R1: a microsomal Vitamin D 25-hydroxylase. J Biol Chem 2003; 278: 38084-38093.
    • (2003) J Biol Chem , vol.278 , pp. 38084-38093
    • Cheng, J.B.1    Motola, D.L.2    Mangelsdorf, D.J.3
  • 10
    • 84884597662 scopus 로고    scopus 로고
    • CYP2R1 is a major, but not exclusive, contributor to 25-hydroxy Vitamin D production in vivo
    • Zhu JG, Ochalek JT, Kaufmann M et al. CYP2R1 is a major, but not exclusive, contributor to 25-hydroxy Vitamin D production in vivo. Proc Natl Acad Sci USA 2013; 110: 15650-15655.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 15650-15655
    • Zhu, J.G.1    Ochalek, J.T.2    Kaufmann, M.3
  • 11
    • 84906790959 scopus 로고    scopus 로고
    • Vitamin D and DBP: The free hormone hypothesis revisited
    • Chun RF, Peercy BE, Orwoll ES et al. Vitamin D and DBP: the free hormone hypothesis revisited. J Steroid Biochem Mol Biol 2014; 144: 132-137.
    • (2014) J Steroid Biochem Mol Biol , vol.144 , pp. 132-137
    • Chun, R.F.1    Peercy, B.E.2    Orwoll, E.S.3
  • 12
    • 0033582543 scopus 로고    scopus 로고
    • An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) Vitamin D3
    • Nykjaer A, Dragun D, Walther D et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) Vitamin D3. Cell 1999; 96: 507-515.
    • (1999) Cell , vol.96 , pp. 507-515
    • Nykjaer, A.1    Dragun, D.2    Walther, D.3
  • 13
    • 0032485525 scopus 로고    scopus 로고
    • Inactivating mutations in the 25-hydroxy Vitamin D3 1alpha-hydroxylase gene in patients with pseudo Vitamin D-deficiency rickets
    • Kitanaka S, Takeyama K, Murayama A et al. Inactivating mutations in the 25-hydroxy Vitamin D3 1alpha-hydroxylase gene in patients with pseudo Vitamin D-deficiency rickets. N Engl J Med 1998; 338: 653-661.
    • (1998) N Engl J Med , vol.338 , pp. 653-661
    • Kitanaka, S.1    Takeyama, K.2    Murayama, A.3
  • 14
    • 84861577327 scopus 로고    scopus 로고
    • 25-Hydroxy Vitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of Vitamin D
    • Jones G, Prosser DE, Kaufmann M. 25-Hydroxy Vitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of Vitamin D. Arch Biochem Biophys 2012; 523: 9-18.
    • (2012) Arch Biochem Biophys , vol.523 , pp. 9-18
    • Jones, G.1    Prosser, D.E.2    Kaufmann, M.3
  • 15
    • 84952361021 scopus 로고    scopus 로고
    • 25-Hydroxy Vitamin D(3) 24-hydroxylase: A key regulator of 1,25(OH)(2)D(3) catabolism and calcium homeostasis
    • Veldurthy V, Wei R, Campbell M et al. 25-Hydroxy Vitamin D(3) 24-hydroxylase: a key regulator of 1,25(OH)(2)D(3) catabolism and calcium homeostasis. Vitam Horm 2016; 100: 137-150.
    • (2016) Vitam Horm , vol.100 , pp. 137-150
    • Veldurthy, V.1    Wei, R.2    Campbell, M.3
  • 16
    • 0003331543 scopus 로고    scopus 로고
    • Deficient mineralization of intramembranous bone in Vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxy Vitamin D and not to the absence of 24,25-dihydroxy Vitamin D
    • St-Arnaud R, Arabian A, Travers R et al. Deficient mineralization of intramembranous bone in Vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxy Vitamin D and not to the absence of 24,25-dihydroxy Vitamin D. Endocrinology 2000; 141: 2658-2666.
    • (2000) Endocrinology , vol.141 , pp. 2658-2666
    • St-Arnaud, R.1    Arabian, A.2    Travers, R.3
  • 17
    • 79961102329 scopus 로고    scopus 로고
    • Mutations in CYP24A1 and idiopathic infantile hypercalcemia
    • Schlingmann KP, Kaufmann M, Weber S et al. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med 2011; 365: 410-421.
    • (2011) N Engl J Med , vol.365 , pp. 410-421
    • Schlingmann, K.P.1    Kaufmann, M.2    Weber, S.3
  • 19
    • 0034282412 scopus 로고    scopus 로고
    • Regulation of 25-hydroxy Vitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxy Vitamin D3
    • Brenza HL, De Luca HF. Regulation of 25-hydroxy Vitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxy Vitamin D3. Arch Biochem Biophys 2000; 381: 143-152.
    • (2000) Arch Biochem Biophys , vol.381 , pp. 143-152
    • Brenza, H.L.1    De Luca, H.F.2
  • 20
    • 84873658813 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and Klotho: Physiology and pathophysiology of an endocrine network of mineral metabolism
    • Hu MC, Shiizaki K, Kuro-o M et al. Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol 2013; 75: 503-533.
    • (2013) Annu Rev Physiol , vol.75 , pp. 503-533
    • Hu, M.C.1    Shiizaki, K.2    Kuro-O, M.3
  • 21
    • 84906790954 scopus 로고    scopus 로고
    • Fundamentals of Vitamin D hormone-regulated gene expression
    • Pike JW, Meyer MB. Fundamentals of Vitamin D hormone-regulated gene expression. J Steroid Biochem Mol Biol 2014; 144: 5-11.
    • (2014) J Steroid Biochem Mol Biol , vol.144 , pp. 5-11
    • Pike, J.W.1    Meyer, M.B.2
  • 22
    • 84950125639 scopus 로고    scopus 로고
    • Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects
    • Christakos S, Dhawan P, Verstuyf A et al. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev 2016; 96: 365-408.
    • (2016) Physiol Rev , vol.96 , pp. 365-408
    • Christakos, S.1    Dhawan, P.2    Verstuyf, A.3
  • 23
    • 0033303655 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype of Vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses
    • Amling M, Priemel M, Holzmann T et al. Rescue of the skeletal phenotype of Vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 1999; 140: 4982-4987.
    • (1999) Endocrinology , vol.140 , pp. 4982-4987
    • Amling, M.1    Priemel, M.2    Holzmann, T.3
  • 24
    • 0000524953 scopus 로고    scopus 로고
    • Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in Vitamin D receptor-ablated mice
    • Li YC, Amling M, Pirro AE et al. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in Vitamin D receptor-ablated mice. Endocrinology 1998; 139: 4391-4396.
    • (1998) Endocrinology , vol.139 , pp. 4391-4396
    • Li, Y.C.1    Amling, M.2    Pirro, A.E.3
  • 25
    • 44249113292 scopus 로고    scopus 로고
    • Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k
    • Benn BS, Ajibade D, Porta A et al. Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology 2008; 149: 3196-3205.
    • (2008) Endocrinology , vol.149 , pp. 3196-3205
    • Benn, B.S.1    Ajibade, D.2    Porta, A.3
  • 26
    • 77955984248 scopus 로고    scopus 로고
    • Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis
    • Lieben L, Benn BS, Ajibade D et al. Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis. Bone 2010; 47: 301-308.
    • (2010) Bone , vol.47 , pp. 301-308
    • Lieben, L.1    Benn, B.S.2    Ajibade, D.3
  • 27
    • 84866705387 scopus 로고    scopus 로고
    • Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and Vitamin D receptor knockout mice
    • Cui M, Li Q, Johnson R et al. Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and Vitamin D receptor knockout mice. J Bone Miner Res 2012; 27: 2097-2107.
    • (2012) J Bone Miner Res , vol.27 , pp. 2097-2107
    • Cui, M.1    Li, Q.2    Johnson, R.3
  • 28
    • 55249111524 scopus 로고    scopus 로고
    • TRPV5: An ingeniously controlled calcium channel
    • de Groot T, Bindels RJ, Hoenderop JG. TRPV5: an ingeniously controlled calcium channel. Kidney Int 2008; 74: 1241-1246.
    • (2008) Kidney Int , vol.74 , pp. 1241-1246
    • De Groot, T.1    Bindels, R.J.2    Hoenderop, J.G.3
  • 29
    • 84862681805 scopus 로고    scopus 로고
    • Mechanism of action of 1.25 dihydroxy Vitamin D3 in intestinal calcium absorption and renal calcium transport
    • Holick MF. Totowa: Humana Press
    • Ajibade D, Benn BS, Christakos S. Mechanism of action of 1.25 dihydroxy Vitamin D3 in intestinal calcium absorption and renal calcium transport//Holick MF. Vitamin D: Physiology, Molecular, Biological and Clinical Applications. Totowa: Humana Press, 2010: 175-187.
    • (2010) Vitamin D: Physiology, Molecular, Biological and Clinical Applications , pp. 175-187
    • Ajibade, D.1    Benn, B.S.2    Christakos, S.3
  • 30
    • 0036720339 scopus 로고    scopus 로고
    • Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxy Vitamin D3 in 25-hydroxy Vitamin D3-1alpha-hydroxylase knockout mice
    • Hoenderop JG, Dardenne O, Van Abel M et al. Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxy Vitamin D3 in 25-hydroxy Vitamin D3-1alpha-hydroxylase knockout mice. FASEB J 2002; 16: 1398-1406.
    • (2002) FASEB J , vol.16 , pp. 1398-1406
    • Hoenderop, J.G.1    Dardenne, O.2    Van Abel, M.3
  • 31
    • 0347320924 scopus 로고    scopus 로고
    • Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5
    • Hoenderop JG, van Leeuwen JP, van der Eerden BC et al. Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 2003; 112: 1906-1914.
    • (2003) J Clin Invest , vol.112 , pp. 1906-1914
    • Hoenderop, J.G.1    Van Leeuwen, J.P.2    Van-Der-Eerden, B.C.3
  • 32
    • 0018484816 scopus 로고
    • Effect of age on intestinal calcium absorption and adaptation to dietary calcium
    • Armbrecht HJ, Zenser TV, Bruns ME et al. Effect of age on intestinal calcium absorption and adaptation to dietary calcium. Am J Physiol 1979; 236: E769-E774.
    • (1979) Am J Physiol , vol.236 , pp. E769-E774
    • Armbrecht, H.J.1    Zenser, T.V.2    Bruns, M.E.3
  • 33
    • 33845366513 scopus 로고    scopus 로고
    • Age-dependent alterations in Ca2+ homeostasis: Role of TRPV5 and TRPV6
    • van Abel M, Huybers S, Hoenderop JG et al. Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6. Am J Physiol Renal Physiol 2006; 291: F1177-F1183.
    • (2006) Am J Physiol Renal Physiol , vol.291 , pp. F1177-F1183
    • Van Abel, M.1    Huybers, S.2    Hoenderop, J.G.3
  • 34
    • 16244406577 scopus 로고    scopus 로고
    • Effect of age, Vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels
    • Brown AJ, Krits I, Armbrecht HJ. Effect of age, Vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels. Arch Biochem Biophys 2005; 437: 51-58.
    • (2005) Arch Biochem Biophys , vol.437 , pp. 51-58
    • Brown, A.J.1    Krits, I.2    Armbrecht, H.J.3
  • 35
    • 0029147660 scopus 로고
    • Variable in vivo regulation of rat Vitamin D-dependent genes (osteopontin, Ca, Mg-adenosine triphosphatase, and 25-hydroxy Vitamin D3 24-hydroxylase): Implications for differing mechanisms of regulation and involvement of multiple factors
    • Matkovits T, Christakos S. Variable in vivo regulation of rat Vitamin D-dependent genes (osteopontin, Ca, Mg-adenosine triphosphatase, and 25-hydroxy Vitamin D3 24-hydroxylase): implications for differing mechanisms of regulation and involvement of multiple factors. Endocrinology 1995; 136: 3971-3982.
    • (1995) Endocrinology , vol.136 , pp. 3971-3982
    • Matkovits, T.1    Christakos, S.2
  • 36
    • 0029584544 scopus 로고
    • Age and gender effects on 1,25-dihydroxy Vitamin D3-regulated gene expression
    • Johnson JA, Beckman MJ, Pansini-Porta A et al. Age and gender effects on 1,25-dihydroxy Vitamin D3-regulated gene expression. Exp Gerontol 1995; 30: 631-643.
    • (1995) Exp Gerontol , vol.30 , pp. 631-643
    • Johnson, J.A.1    Beckman, M.J.2    Pansini-Porta, A.3
  • 37
    • 0019212253 scopus 로고
    • Effect of age on the conversion of 25-hydroxy Vitamin D3 to 1,25-dihydroxy Vitamin D3 by kidney of rat
    • Armbrecht HJ, Zenser TV, Davis BB. Effect of age on the conversion of 25-hydroxy Vitamin D3 to 1,25-dihydroxy Vitamin D3 by kidney of rat. J Clin Invest 1980; 66: 1118-1123.
    • (1980) J Clin Invest , vol.66 , pp. 1118-1123
    • Armbrecht, H.J.1    Zenser, T.V.2    Davis, B.B.3
  • 38
    • 0034523424 scopus 로고    scopus 로고
    • Relationship of intestinal calcium absorption to 1,25-dihydroxy Vitamin D [1,25(OH)2D] levels in young versus elderly women: Evidence for age-related intestinal resistance to 1,25(OH)2D action
    • Pattanaungkul S, Riggs BL, Yergey AL et al. Relationship of intestinal calcium absorption to 1,25-dihydroxy Vitamin D [1,25(OH)2D] levels in young versus elderly women: evidence for age-related intestinal resistance to 1,25(OH)2D action. J Clin Endocrinol Metab 2000; 85: 4023-4027.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4023-4027
    • Pattanaungkul, S.1    Riggs, B.L.2    Yergey, A.L.3
  • 39
    • 0026723886 scopus 로고
    • Evidence of an age-related decrease in intestinal responsiveness to Vitamin D: Relationship between serum 1,25-dihydroxy Vitamin D3 and intestinal Vitamin D receptor concentrations in normal women
    • Ebeling PR, Sandgren ME, Di Magno EP et al. Evidence of an age-related decrease in intestinal responsiveness to Vitamin D: relationship between serum 1,25-dihydroxy Vitamin D3 and intestinal Vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab 1992; 75: 176-182.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 176-182
    • Ebeling, P.R.1    Sandgren, M.E.2    Di Magno, E.P.3
  • 40
    • 0025156981 scopus 로고
    • Advancing age results in reduction of intestinal and bone 1,25-dihydroxy Vitamin D receptor
    • Horst RL, Goff JP, Reinhardt TA. Advancing age results in reduction of intestinal and bone 1,25-dihydroxy Vitamin D receptor. Endocrinology 1990; 126: 1053-1057.
    • (1990) Endocrinology , vol.126 , pp. 1053-1057
    • Horst, R.L.1    Goff, J.P.2    Reinhardt, T.A.3
  • 41
    • 0031010187 scopus 로고    scopus 로고
    • Association between intestinal Vitamin D receptor, calcium absorption, and serum 1,25 dihydroxy Vitamin D in normal young and elderly women
    • Kinyamu HK, Gallagher JC, Prahl JM et al. Association between intestinal Vitamin D receptor, calcium absorption, and serum 1,25 dihydroxy Vitamin D in normal young and elderly women. J Bone Miner Res 1997; 12: 922-928.
    • (1997) J Bone Miner Res , vol.12 , pp. 922-928
    • Kinyamu, H.K.1    Gallagher, J.C.2    Prahl, J.M.3
  • 42
    • 0031730907 scopus 로고    scopus 로고
    • Intestinal calcium absorption in the aged rat: Evidence of intestinal resistance to 1,25(OH)2 Vitamin D
    • Wood RJ, Fleet JC, Cashman K et al. Intestinal calcium absorption in the aged rat: evidence of intestinal resistance to 1,25(OH)2 Vitamin D. Endocrinology 1998; 139: 3843-3848.
    • (1998) Endocrinology , vol.139 , pp. 3843-3848
    • Wood, R.J.1    Fleet, J.C.2    Cashman, K.3
  • 44
    • 0025732102 scopus 로고
    • Calcium metabolism in early chronic renal failure: Implications for the pathogenesis of hyperparathyroidism
    • Reichel H, Deibert B, Schmidt-Gayk H et al. Calcium metabolism in early chronic renal failure: implications for the pathogenesis of hyperparathyroidism. Nephrol Dial Transplant 1991; 6: 162-169.
    • (1991) Nephrol Dial Transplant , vol.6 , pp. 162-169
    • Reichel, H.1    Deibert, B.2    Schmidt-Gayk, H.3
  • 45
    • 84859852194 scopus 로고    scopus 로고
    • Role of FGF23 in Vitamin D and phosphate metabolism: Implications in chronic kidney disease
    • Quarles LD. Role of FGF23 in Vitamin D and phosphate metabolism: implications in chronic kidney disease. Exp Cell Res 2012; 318: 1040-1048.
    • (2012) Exp Cell Res , vol.318 , pp. 1040-1048
    • Quarles, L.D.1
  • 46
    • 0020202039 scopus 로고
    • Differential effects of parathyroid hormone on the renal 1,25-dihydroxy Vitamin D3 and 24,25-dihydroxy Vitamin D3 production of young and adult rats
    • Armbrecht HJ, Wongsurawat N, Zenser TV et al. Differential effects of parathyroid hormone on the renal 1,25-dihydroxy Vitamin D3 and 24,25-dihydroxy Vitamin D3 production of young and adult rats. Endocrinology 1982; 111: 1339-1344.
    • (1982) Endocrinology , vol.111 , pp. 1339-1344
    • Armbrecht, H.J.1    Wongsurawat, N.2    Zenser, T.V.3
  • 47
    • 0031979744 scopus 로고    scopus 로고
    • Changes in renal phosphate reabsorption in the aged rat
    • Mulroney SE, Woda C, Haramati A. Changes in renal phosphate reabsorption in the aged rat. Proc Soc Exp Biol Med 1998; 218: 62-67.
    • (1998) Proc Soc Exp Biol Med , vol.218 , pp. 62-67
    • Mulroney, S.E.1    Woda, C.2    Haramati, A.3
  • 48
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: Concepts, conflicts, and prospects
    • Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 2005; 115: 3318-3325.
    • (2005) J Clin Invest , vol.115 , pp. 3318-3325
    • Raisz, L.G.1
  • 49
    • 84919418591 scopus 로고    scopus 로고
    • Clinician's guide to prevention and treatment of osteoporosis
    • Cosman F, de Beur SJ, Le Boff MS et al. Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int 2014; 25: 2359-2381.
    • (2014) Osteoporos Int , vol.25 , pp. 2359-2381
    • Cosman, F.1    De Beur, S.J.2    Le Boff, M.S.3
  • 50
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • Riggs BL, Khosla S, Melton LJ 3rd. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002; 23: 279-302.
    • (2002) Endocr Rev , vol.23 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton, L.J.3
  • 51
    • 84930211948 scopus 로고    scopus 로고
    • Estrogen and bone health in men and women
    • Cauley JA. Estrogen and bone health in men and women. Steroids 2015; 99: 11-15.
    • (2015) Steroids , vol.99 , pp. 11-15
    • Cauley, J.A.1
  • 52
    • 49849086694 scopus 로고    scopus 로고
    • Serum 25 hydroxy Vitamin D concentrations and the risk of hip fractures: The women's health initiative
    • Cauley JA, La Croix AZ, Wu L et al. Serum 25 hydroxy Vitamin D concentrations and the risk of hip fractures: the women's health initiative. Ann Intern Med 2008; 149: 242-250.
    • (2008) Ann Intern Med , vol.149 , pp. 242-250
    • Cauley, J.A.1    La Croix, A.Z.2    Wu, L.3
  • 53
    • 78650886291 scopus 로고    scopus 로고
    • The 2011 report on dietary reference intakes for calcium and Vitamin D from the Institute of Medicine: What clinicians need to know
    • Ross AC, Manson JE, Abrams SA et al. The 2011 report on dietary reference intakes for calcium and Vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; 96: 53-58.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 53-58
    • Ross, A.C.1    Manson, J.E.2    Abrams, S.A.3
  • 54
    • 79960104336 scopus 로고    scopus 로고
    • Evaluation, treatment, and prevention of Vitamin D deficiency: An Endocrine Society clinical practice guideline
    • Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of Vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1911-1930
    • Holick, M.F.1    Binkley, N.C.2    Bischoff-Ferrari, H.A.3
  • 55
    • 84863393274 scopus 로고    scopus 로고
    • Dose response to Vitamin D supplementation in postmenopausal women: A randomized trial
    • Gallagher JC, Sai A, Templin T 2nd et al. Dose response to Vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med 2012; 156: 425-437.
    • (2012) Ann Intern Med , vol.156 , pp. 425-437
    • Gallagher, J.C.1    Sai, A.2    Templin, T.3
  • 56
    • 77953443605 scopus 로고    scopus 로고
    • Bone mineralization defects and Vitamin D deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxy Vitamin D in 675 patients
    • Priemel M, von Domarus C, Klatte TO et al. Bone mineralization defects and Vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxy Vitamin D in 675 patients. J Bone Miner Res 2010; 25: 305-312.
    • (2010) J Bone Miner Res , vol.25 , pp. 305-312
    • Priemel, M.1    Von Domarus, C.2    Klatte, T.O.3
  • 57
    • 84906789954 scopus 로고    scopus 로고
    • DNA methylation levels of CYP2R1 and CYP24A1 predict Vitamin D response variation
    • Zhou Y, Zhao LJ, Xu X et al. DNA methylation levels of CYP2R1 and CYP24A1 predict Vitamin D response variation. J Steroid Biochem Mol Biol 2014; 144: 207-214.
    • (2014) J Steroid Biochem Mol Biol , vol.144 , pp. 207-214
    • Zhou, Y.1    Zhao, L.J.2    Xu, X.3
  • 59
    • 84899900531 scopus 로고    scopus 로고
    • Prevention and treatment of postmenopausal osteoporosis
    • Tella SH, Gallagher JC. Prevention and treatment of postmenopausal osteoporosis. J Steroid Biochem Mol Biol 2014; 142: 155-170.
    • (2014) J Steroid Biochem Mol Biol , vol.142 , pp. 155-170
    • Tella, S.H.1    Gallagher, J.C.2
  • 60
    • 79959744770 scopus 로고    scopus 로고
    • Randomized trial of alendronate plus Vitamin D3 versus standard care in osteoporotic postmenopausal women with Vitamin D insufficiency
    • Ralston SH, Binkley N, Boonen S et al. Randomized trial of alendronate plus Vitamin D3 versus standard care in osteoporotic postmenopausal women with Vitamin D insufficiency. Calcif Tissue Int 2011; 88: 485-494.
    • (2011) Calcif Tissue Int , vol.88 , pp. 485-494
    • Ralston, S.H.1    Binkley, N.2    Boonen, S.3
  • 61
    • 4344604516 scopus 로고    scopus 로고
    • 1 Alpha-hydroxy Vitamin D2 and 1 alpha-hydroxy Vitamin D3 have anabolic effects on cortical bone, but induce intracortical remodeling at toxic doses in ovariectomized rats
    • Weber K, Kaschig C, Erben RG. 1 Alpha-hydroxy Vitamin D2 and 1 alpha-hydroxy Vitamin D3 have anabolic effects on cortical bone, but induce intracortical remodeling at toxic doses in ovariectomized rats. Bone 2004; 35: 704-710.
    • (2004) Bone , vol.35 , pp. 704-710
    • Weber, K.1    Kaschig, C.2    Erben, R.G.3
  • 63
    • 0028333585 scopus 로고
    • Effects of 1 alpha-hydroxy Vitamin D3 on lumbar bone mineral density and vertebral fractures in patients with postmenopausal osteoporosis
    • Orimo H, Shiraki M, Hayashi Y et al. Effects of 1 alpha-hydroxy Vitamin D3 on lumbar bone mineral density and vertebral fractures in patients with postmenopausal osteoporosis. Calcif Tissue Int 1994; 54: 370-376.
    • (1994) Calcif Tissue Int , vol.54 , pp. 370-376
    • Orimo, H.1    Shiraki, M.2    Hayashi, Y.3
  • 64
    • 0029999377 scopus 로고    scopus 로고
    • H. Effects of 2 years' treatment of osteoporosis with 1 alpha-hydroxy Vitamin D3 on bone mineral density and incidence of fracture: A placebo-controlled, doubleblind prospective study
    • Shikari Kushida M, Yamazaki K, Nagai K et al. H. Effects of 2 years' treatment of osteoporosis with 1 alpha-hydroxy Vitamin D3 on bone mineral density and incidence of fracture: a placebo-controlled, doubleblind prospective study. Endocr J 1996; 43: 211-220.
    • (1996) Endocr J , vol.43 , pp. 211-220
    • Shikari Kushida, M.1    Yamazaki, K.2    Nagai, K.3
  • 65
    • 0001887481 scopus 로고
    • Decrease of vertebral fracture in osteoporotics by administration of 1α-hydroxy-Vitamin D3
    • Hayashi Y, Fujita T, Inoue T. Decrease of vertebral fracture in osteoporotics by administration of 1α-hydroxy-Vitamin D3. J Bone Miner Metab 1992; 10: 50-54.
    • (1992) J Bone Miner Metab , vol.10 , pp. 50-54
    • Hayashi, Y.1    Fujita, T.2    Inoue, T.3
  • 66
    • 33644619587 scopus 로고    scopus 로고
    • Superiority of alfacalcidol compared to Vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis
    • Nuti R, Bianchi G, Brandi ML et al. Superiority of alfacalcidol compared to Vitamin D plus calcium in lumbar bone mineral density in postmenopausal osteoporosis. Rheumatol Int 2006; 26: 445-453.
    • (2006) Rheumatol Int , vol.26 , pp. 445-453
    • Nuti, R.1    Bianchi, G.2    Brandi, M.L.3
  • 67
    • 0037303766 scopus 로고    scopus 로고
    • A new active Vitamin D analog, ED-71, causes increase in bone mass with preferential effects on bone in osteoporotic patients
    • Kubodera N, Tsuji N, Uchiyama Y et al. A new active Vitamin D analog, ED-71, causes increase in bone mass with preferential effects on bone in osteoporotic patients. J Cell Biochem 2003; 88: 286-289.
    • (2003) J Cell Biochem , vol.88 , pp. 286-289
    • Kubodera, N.1    Tsuji, N.2    Uchiyama, Y.3
  • 68
    • 79955439317 scopus 로고    scopus 로고
    • Overview of the clinical pharmacokinetics of eldecalcitol, a new active Vitamin D3 derivative
    • Abe M, Tsuji N, Takahashi F et al. Overview of the clinical pharmacokinetics of eldecalcitol, a new active Vitamin D3 derivative. Jpn Pharmacol Ther 2011; 39: 261-274.
    • (2011) Jpn Pharmacol Ther , vol.39 , pp. 261-274
    • Abe, M.1    Tsuji, N.2    Takahashi, F.3
  • 69
    • 79953684005 scopus 로고    scopus 로고
    • Suppression of PTH by the Vitamin D analog eldecalcitol is modulated by its high affinity for the serum Vitamin D-binding protein and resistance to metabolism
    • Ritter CS, Brown AJ. Suppression of PTH by the Vitamin D analog eldecalcitol is modulated by its high affinity for the serum Vitamin D-binding protein and resistance to metabolism. J Cell Biochem 2011; 112: 1348-1352.
    • (2011) J Cell Biochem , vol.112 , pp. 1348-1352
    • Ritter, C.S.1    Brown, A.J.2
  • 70
    • 84925462868 scopus 로고    scopus 로고
    • Eldecalcitol reduces osteoporotic fractures by unique mechanisms
    • Kondo S, Takano T, Ono Y et al. Eldecalcitol reduces osteoporotic fractures by unique mechanisms. J Steroid Biochem Mol Biol 2015; 148: 232-238.
    • (2015) J Steroid Biochem Mol Biol , vol.148 , pp. 232-238
    • Kondo, S.1    Takano, T.2    Ono, Y.3
  • 71
    • 84856200641 scopus 로고    scopus 로고
    • Daily administration of eldecalcitol (ED-71), an active Vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone
    • Harada S, Mizoguchi T, Kobayashi Y et al. Daily administration of eldecalcitol (ED-71), an active Vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone. J Bone Miner Res 2012; 27: 461-473.
    • (2012) J Bone Miner Res , vol.27 , pp. 461-473
    • Harada, S.1    Mizoguchi, T.2    Kobayashi, Y.3
  • 72
    • 84919618979 scopus 로고    scopus 로고
    • Treatment with eldecalcitol positively affects mineralization, microdamage, and collagen crosslinks in primate bone
    • Saito M, Grynpas MD, Burr DB et al. Treatment with eldecalcitol positively affects mineralization, microdamage, and collagen crosslinks in primate bone. Bone 2015; 73: 8-15.
    • (2015) Bone , vol.73 , pp. 8-15
    • Saito, M.1    Grynpas, M.D.2    Burr, D.B.3
  • 73
    • 80052278079 scopus 로고    scopus 로고
    • A new active Vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures-A randomized, active comparator, double-blind study
    • Matsumoto T, Ito M, Hayashi Y et al. A new active Vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures-a randomized, active comparator, double-blind study. Bone 2011; 49: 605-612.
    • (2011) Bone , vol.49 , pp. 605-612
    • Matsumoto, T.1    Ito, M.2    Hayashi, Y.3
  • 74
    • 84919666019 scopus 로고    scopus 로고
    • Vitamin D analogs and bone: Preclinical and clinical studies with eldecalcitol
    • Matsumoto T, Takano T, Saito H et al. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol. Bonekey Rep 2014; 3: 513.
    • (2014) Bonekey Rep , vol.3 , pp. 513
    • Matsumoto, T.1    Takano, T.2    Saito, H.3
  • 75
    • 84925497236 scopus 로고    scopus 로고
    • Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active Vitamin D analog, compared to that of concomitant ALN, Vitamin D plus calcium treatment in Japanese patients with primary osteoporosis
    • Sakai A, Ito M, Tomomitsu T et al. Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active Vitamin D analog, compared to that of concomitant ALN, Vitamin D plus calcium treatment in Japanese patients with primary osteoporosis. Osteoporos Int 2015; 26: 1193-1202.
    • (2015) Osteoporos Int , vol.26 , pp. 1193-1202
    • Sakai, A.1    Ito, M.2    Tomomitsu, T.3
  • 76
    • 33645755226 scopus 로고    scopus 로고
    • 2MD, a new anabolic agent for osteoporosis treatment
    • Plum LA, Fitzpatrick LA, Ma X et al. 2MD, a new anabolic agent for osteoporosis treatment. Osteoporos Int 2006; 17: 704-715.
    • (2006) Osteoporos Int , vol.17 , pp. 704-715
    • Plum, L.A.1    Fitzpatrick, L.A.2    Ma, X.3
  • 77
    • 25444453190 scopus 로고    scopus 로고
    • A new Vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia
    • Ke HZ, Qi H, Crawford DT et al. A new Vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res 2005; 20: 1742-1755.
    • (2005) J Bone Miner Res , vol.20 , pp. 1742-1755
    • Ke, H.Z.1    Qi, H.2    Crawford, D.T.3
  • 78
    • 78649717331 scopus 로고    scopus 로고
    • The Vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: Results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial
    • De Luca HF, Bedale W, Binkley N et al. The Vitamin D analogue 2MD increases bone turnover but not BMD in postmenopausal women with osteopenia: results of a 1-year phase 2 double-blind, placebo-controlled, randomized clinical trial. J Bone Miner Res 2011; 26: 538-545.
    • (2011) J Bone Miner Res , vol.26 , pp. 538-545
    • De Luca, H.F.1    Bedale, W.2    Binkley, N.3
  • 79
    • 84900886470 scopus 로고    scopus 로고
    • Novel, selective Vitamin D analog suppresses parathyroid hormone in uremic animals and postmenopausal women
    • Zella JB, Plum LA, Plowchalk DR et al. Novel, selective Vitamin D analog suppresses parathyroid hormone in uremic animals and postmenopausal women. Am J Nephrol 2014; 39: 476-483.
    • (2014) Am J Nephrol , vol.39 , pp. 476-483
    • Zella, J.B.1    Plum, L.A.2    Plowchalk, D.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.