Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis

Bone

Volumn 47, Issue 2, 2010, Pages 301-308

  Lieben, L ^a   Benn, B S ^b   Ajibade, D ^b   Stockmans, I ^a   Moermans, K ^a   Hediger, M A ^c   Peng, J B ^d   Christakos, S ^b   Bouillon, R ^a   Carmeliet, G ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

^d University of Alabama at Birmingham   (United States)

Author keywords

1,25(OH)2D3; Bone remodeling; Hyperosteoidosis; Intestinal calcium absorption; TRPV6

Indexed keywords

CALCIUM; OSTEOCALCIN; VANILLOID RECEPTOR 6; CALCIUM CHANNEL; CALCIUM INTAKE; MESSENGER RNA; PHOSPHATE; TRPV6 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE METABOLISM; BONE MINERALIZATION; BONE REMODELING; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CALCIUM TRANSPORT; CONTROLLED STUDY; DIET RESTRICTION; DIFFUSION; GENE FUNCTION; GENE INACTIVATION; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; PHENOTYPE; AGING; ANIMAL; BLOOD; BONE; BONE DEVELOPMENT; CHANNEL GATING; DEFICIENCY; DRUG EFFECTS; DUODENUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; INTESTINE ABSORPTION; METABOLISM; ORGAN SIZE; PATHOLOGY; PHARMACOLOGY;

AGING; ANIMALS; BONE AND BONES; BONE REMODELING; CALCIUM; CALCIUM CHANNELS; CALCIUM, DIETARY; DUODENUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEOSTASIS; INTESTINAL ABSORPTION; ION CHANNEL GATING; MICE; ORGAN SIZE; OSTEOGENESIS; PHOSPHATES; RNA, MESSENGER; TRPV CATION CHANNELS;

EID: 77955984248     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.04.595     Document Type: Article

References (40)

1. Van Cromphaut S.J., Dewerchin M., Hoenderop J.G., Stockmans I., Van Herck E., Kato S., et al. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A 2001, 98:13324-13329.
2. Balsan S., Garabedian M., Larchet M., Gorski A.M., Cournot G., Tau C., et al. Long-term nocturnal calcium infusions can cure rickets and promote normal mineralization in hereditary resistance to 1, 25-dihydroxyvitamin D. J. Clin. Invest 1986, 77:1661-1667.
3. Panda D.K., Miao D., Tremblay M.L., Sirois J., Farookhi R., Hendy G.N., et al. Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci U.S.A 2001, 98:7498-7503.
4. Yoshizawa T., Handa Y., Uematsu Y., Takeda S., Sekine K., Yoshihara Y., et al. Mice acking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 1997, 16:391-396.
5. Dardenne O., Prud'homme J., Hacking S.A., Glorieux F.H., St Arnaud R. Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1). Bone 2003, 32:332-340.
6. Hochberg Z., Tiosano D., Even L. Calcium therapy for calcitriol-resistant rickets. J Pediatr 1992, 121:803-808.
7. Li Y.C., Amling M., Pirro A.E., Priemel M., Meuse J., Baron R., et al. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 1998, 139:4391-4396.
8. Bouillon R., Carmeliet G., Verlinden L., van Etten E., Verstuyf A., Luderer H.F., et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008, 29:726-776.
9. van Abel M., Hoenderop J.G., van der Kemp A.W., van Leeuwen J.P., Bindels R.J. Regulation of the epithelial Ca2+ channels in small intestine as studied by quantitative mRNA detection. Am J Physiol Gastrointest Liver Physiol 2003, 285:G78-G85.
10. Benn B.S., Ajibade D., Porta A., Dhawan P., Hediger M., Peng J.B., et al. Active intestinal calcium transport in the absence of TRPV6 and Calbindin-D9k. Endocrinology 2008, 149:3196-3205.
11. Bianco S.D., Peng J.B., Takanaga H., Suzuki Y., Crescenzi A., Kos C.H., et al. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner. Res. 2007, 22:274-285.
12. Maes C., Coenegrachts L., Stockmans I., Daci E., Luttun A., Petryk A., et al. Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. J Clin. Invest 2006, 116:1230-1242.
13. Verhaeghe J., Van Herck E., van Bree R., Van Assche F.A., Bouillon R. Osteocalcin during the reproductive cycle in normal and diabetic rats. J Endocrinol 1989, 120:143-151.
14. Daci E., Verstuyf A., Moermans K., Bouillon R., Carmeliet G. Mice lacking the plasminogen activator inhibitor 1 are protected from trabecular bone loss induced by estrogen deficiency. J Bone Miner. Res. 2000, 15:1510-1516.
15. Masuyama R., Nakaya Y., Katsumata S., Kajita Y., Uehara M., Tanaka S., et al. Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption. J Bone Miner. Res. 2003, 18:1217-1226.
16. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987, 2:595-610.
17. Masuyama R., Stockmans I., Torrekens S., Van Looveren R., Maes C., Carmeliet P., et al. Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin. Invest 2006, 116:3150-3159.
18. Kinyamu H.K., Gallagher J.C., Prahl J.M., DeLuca H.F., Petranick K.M., Lanspa S.J. Association between intestinal vitamin D receptor, calcium absorption, and serum 1, 25 dihydroxyvitamin D in normal young and elderly women. J. Bone Miner. Res. 1997, 12:922-928.
19. FOLLIS R.H. Some unsolved problems concerning the pathogenesis of human deficiency disease syndromes. Am J Clin Nutr 1958, 6:459-465.
20. van der Eerden B.C., Hoenderop J.G., de Vries T.J., Schoenmaker T., Buurman C.J., Uitterlinden A.G., et al. The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci U.S.A 2005, 102:17507-17512.
21. Weber K., Erben R.G., Rump A., Adamski J. Gene structure and regulation of the murine epithelial calcium channels ECaC1 and 2. Biochem Biophys Res Commun 2001, 289:1287-1294.
22. Nijenhuis T., Hoenderop J.G., van der Kemp A.W., Bindels R.J. Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. J Am Soc Nephrol 2003, 14:2731-2740.
23. Balesaria S., Sangha S., Walters J.R. Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol 2009, 297:G1193-G1197.
24. Barley N.F., Howard A., O'Callaghan D., Legon S., Walters J.R. Epithelial calcium transporter expression in human duodenum. Am J Physiol Gastrointest Liver Physiol 2001, 280:G285-G290.
25. Peng J.B., Chen X.Z., Berger U.V., Vassilev P.M., Tsukaguchi H., Brown E.M., et al. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J. Biol Chem. 1999, 274:22739-22746.
26. Hirnet D., Olausson J., Fecher-Trost C., Bodding M., Nastainczyk W., Wissenbach U., et al. The TRPV6 gene, cDNA and protein. Cell Calcium 2003, 33:509-518.
27. Bullamore J.R., Wilkinson R., Gallagher J.C., Nordin B.E., Marshall D.H. Effect of age on calcium absorption. Lancet 1970, 2:535-537.
28. Berlyne G.M., Ben Ari J., Kushelevsky A., Idelman A., Galinsky D., Hirsch M., et al. The aetiology of senile osteoporosis: secondary hyperparathyroidism due to renal failure. QJ Med 1975, 44:505-521.
29. Bouillon R., Carmeliet G., Boonen S. Ageing and calcium metabolism. Baillieres Clin Endocrinol Metab 1997, 11:341-365.
30. Gallagher J.C., Riggs B.L., Eisman J., Hamstra A., Arnaud S.B., DeLuca H.F. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest 1979, 64:729-736.
31. Nordin B.E., Need A.G., Morris H.A., O'Loughlin P.D., Horowitz M. Effect of age on calcium absorption in postmenopausal women. Am J Clin Nutr 2004, 80:998-1002.
32. Kiebzak G.M., Smith R., Gundberg C.C., Howe J.C., Sacktor B. Bone status of senescent male rats: chemical, morphometric, and mechanical analysis. J Bone Miner Res 1988, 3:37-45.
33. Armbrecht H.J., Zenser T.V., Gross C.J., Davis B.B. Adaptation to dietary calcium and phosphorus restriction changes with age in the rat. Am J Physiol 1980, 239:E322-E327.
34. Armbrecht H.J., Boltz M.A., Bruns M.E. Effect of age and dietary calcium on intestinal calbindin D-9k expression in the rat. Arch Biochem Biophys 2003, 420:194-200.
35. Brown A.J., Krits I., Armbrecht H.J. Effect of age, vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels. Arch Biochem Biophys 2005, 437:51-58.
36. Song Y., Peng X., Porta A., Takanaga H., Peng J.B., Hediger M.A., et al. Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1, 25 dihydroxyvitamin D3 in the intestine and kidney of mice. Endocrinology 2003, 144:3885-3894.
37. Akhter S., Kutuzova G.D., Christakos S., DeLuca H.F. Calbindin D(9k) is not required for 1,25-dihydroxyvitamin D(3)-mediated Ca(2+) absorption in small intestine. Arch Biochem Biophys 2006, 460:227-232.
38. Chirayath M.V., Gajdzik L., Hulla W., Graf J., Cross H.S., Peterlik M. Vitamin D increases tight-junction conductance and paracellular Ca2+ transport in Caco-2 cell cultures. Am J Physiol 1998, 274:G389-G396.
39. Kutuzova G.D., DeLuca H.F. Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D(3) stimulated calcium absorption and clarify its immunomodulatory properties. Arch Biochem Biophys 2004, 432:152-166.
40. Fujita H., Sugimoto K., Inatomi S., Maeda T., Osanai M., Uchiyama Y., et al. Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mo. Biol Cell 2008, 19:1912-1921.