25-Hydroxyvitamin D3 24-Hydroxylase. A Key Regulator of 1,25(OH)2D3 Catabolism and Calcium Homeostasis.

Vitamins and Hormones

Volumn 100, Issue , 2016, Pages 137-150

  Veldurthy, Vaishali ^a   Wei, Ran ^a   Campbell, Megan ^a   Lupicki, Kamil ^a   Dhawan, Puneet ^a   Christakos, Sylvia ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

25 Hydroxyvitamin D3 24 hydroxylase; Fibroblast growth factor 23; Parathyroid hormone; Transcription; Vitamin D receptor

Indexed keywords

CALCITRIOL; CALCIUM; COLECALCIFEROL 24 HYDROXYLASE;

ANIMAL; CHEMISTRY; HOMEOSTASIS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION;

ANIMALS; CALCITRIOL; CALCIUM; HOMEOSTASIS; HUMANS; PROTEIN CONFORMATION; VITAMIN D3 24-HYDROXYLASE;

EID: 84952361021     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.vh.2015.10.005     Document Type: Chapter

References (57)

1. Annalora A.J., Goodin D.B., Hong W.X., Zhang Q., Johnson E.F., Stout C.D. Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism. Journal of Molecular Biology 2010, 396(2):441-451. 10.1016/j.jmb.2009.11.057.
2. Armbrecht H.J., Zenser T.V., Bruns M.E., Davis B.B. Effect of age on intestinal calcium absorption and adaptation to dietary calcium. The American Journal of Physiology 1979, 236(6):E769-E774.
3. Armbrecht H.J., Zenser T.V., Davis B.B. Effect of age on the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 by kidney of rat. The Journal of Clinical Investigation 1980, 66(5):1118-1123. 10.1172/JCI109941.
4. Bikle D.D. Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & Biology 2014, 21(3):319-329. 10.1016/j.chembiol.2013.12.016.
5. Bonewald L.F., Wacker M.J. FGF23 production by osteocytes. Pediatric Nephrology 2013, 28(4):563-568. 10.1007/s00467-012-2309-3.
6. Christakos S. Vitamin D gene regulation. Principles of bone biology 2008, 779-794. Academic Press, New York, NY. J. Bilezikian, L. Raisz, T.J. Martin (Eds.).
7. Christakos S., Dhawan P., Benn B., Porta A., Hediger M., Oh G.T., et al. Vitamin D: Molecular mechanism of action. Annals of the New York Academy of Sciences 2007, 1116:340-348. 10.1196/annals.1402.070.
8. Colussi G., Ganon L., Penco S., De Ferrari M.E., Ravera F., Querques M., et al. Chronic hypercalcaemia from inactivating mutations of vitamin D 24-hydroxylase (CYP24A1): Implications for mineral metabolism changes in chronic renal failure. Nephrology, Dialysis, Transplantation 2014, 29(3):636-643. 10.1093/ndt/gft460.
9. Delvin E.E., Arabian A., Glorieux F.H., Mamer O.A. In vitro metabolism of 25-hydroxycholecalciferol by isolated cells from human decidua. The Journal of Clinical Endocrinology and Metabolism 1985, 60(5):880-885. 10.1210/jcem-60-5-880.
10. Dhawan P., Peng X., Sutton A.L., MacDonald P.N., Croniger C.M., Trautwein C., et al. Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase. Molecular and Cellular Biology 2005, 25(1):472-487. 10.1128/MCB.25.1.472-487.2005.
11. Dinour D., Beckerman P., Ganon L., Tordjman K., Eisenstein Z., Holtzman E.J. Loss-of-function mutations of CYP24A1, the vitamin D 24-hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis. The Journal of Urology 2013, 190(2):552-557. 10.1016/j.juro.2013.02.3188.
12. Dinour D., Davidovits M., Aviner S., Ganon L., Michael L., Modan-Moses D., et al. Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake. Pediatric Nephrology 2015, 30(1):145-152. 10.1007/s00467-014-2889-1.
13. Dwivedi P.P., Omdahl J.L., Kola I., Hume D.A., May B.K. Regulation of rat cytochrome P450C24 (CYP24) gene expression. Evidence for functional cooperation of Ras-activated Ets transcription factors with the vitamin D receptor in 1,25-dihydroxyvitamin D(3)-mediated induction. The Journal of Biological Chemistry 2000, 275(1):47-55.
14. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium. Nature Genetics 1995, 11(2):130-136. 10.1038/ng1095-130.
15. Hahn C.N., Baker E., Laslo P., May B.K., Omdahl J.L., Sutherland G.R. Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2-->q13.3. Cytogenetics and Cell Genetics 1993, 62(4):192-193.
16. Hamamoto H., Kusudo T., Urushino N., Masuno H., Yamamoto K., Yamada S., et al. Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: Amino acid residues responsible for species-based difference of CYP24A1 between humans and rats. Molecular Pharmacology 2006, 70(1):120-128. 10.1124/mol.106.023275.
17. Hobaus J., Hummel D.M., Thiem U., Fetahu I.S., Aggarwal A., Mullauer L., et al. Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer. International Journal of Cancer 2013, 133(6):1380-1388. 10.1002/ijc.28143.
18. Hu M.C., Shiizaki K., Kuro-o M., Moe O.W. Fibroblast growth factor 23 and Klotho: Physiology and pathophysiology of an endocrine network of mineral metabolism. Annual Review of Physiology 2013, 75:503-533. 10.1146/annurev-physiol-030212-183727.
19. Ishizuka S., Kurihara N., Reddy S.V., Cornish J., Cundy T., Roodman G.D. (23S)-25-Dehydro-1-hydroxyvitamin D3-26,23-lactone, a vitamin D receptor antagonist that inhibits osteoclast formation and bone resorption in bone marrow cultures from patients with Paget's disease. Endocrinology 2005, 146(4):2023-2030. 10.1210/en.2004-1140.
20. Jacobs T.P., Kaufman M., Jones G., Kumar R., Schlingmann K.P., Shapses S., et al. A lifetime of hypercalcemia and hypercalciuria, finally explained. The Journal of Clinical Endocrinology and Metabolism 2014, 99(3):708-712. 10.1210/jc.2013-3802.
21. Ji H.F., Shen L. CYP24A1 mutations in idiopathic infantile hypercalcemia. The New England Journal of Medicine 2011, 365(18):1741. author reply 1742-1743. 10.1056/NEJMc1110226#SA1.
22. Johnson J.A., Beckman M.J., Pansini-Porta A., Christakos S., Bruns M.E., Beitz D.C., et al. Age and gender effects on 1,25-dihydroxyvitamin D3-regulated gene expression. Experimental Gerontology 1995, 30(6):631-643.
23. Jones G., Prosser D.E., Kaufmann M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Archives of Biochemistry and Biophysics 2012, 523(1):9-18. 10.1016/j.abb.2011.11.003.
24. Jones G., Prosser D.E., Kaufmann M. Cytochrome P450-mediated metabolism of vitamin D. Journal of Lipid Research 2014, 55(1):13-31. 10.1194/jlr.R031534.
25. Kovacs C.S., Kronenberg H.M. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocrine Reviews 1997, 18(6):832-872. 10.1210/edrv.18.6.0319.
26. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390(6655):45-51. 10.1038/36285.
27. Liu S., Zhou J., Tang W., Jiang X., Rowe D.W., Quarles L.D. Pathogenic role of Fgf23 in Hyp mice. American Journal of Physiology. Endocrinology and Metabolism 2006, 291(1):E38-E49. 10.1152/ajpendo.00008.2006.
28. Martin A., Liu S., David V., Li H., Karydis A., Feng J.Q., et al. Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. The FASEB Journal 2011, 25(8):2551-2562. 10.1096/fj.10-177816.
29. Matkovits T., Christakos S. Variable in vivo regulation of rat vitamin D-dependent genes (osteopontin, Ca, Mg-adenosine triphosphatase, and 25-hydroxyvitamin D3 24-hydroxylase): Implications for differing mechanisms of regulation and involvement of multiple factors. Endocrinology 1995, 136(9):3971-3982. 10.1210/endo.136.9.7649106.
30. Meyer M.B., Goetsch P.D., Pike J.W. A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. The Journal of Biological Chemistry 2010, 285(20):15599-15610. 10.1074/jbc.M110.119958.
31. Narvaez C.J., Matthews D., LaPorta E., Simmons K.M., Beaudin S., Welsh J. The impact of vitamin D in breast cancer: Genomics, pathways, metabolism. Frontiers in Physiology 2014, 5:213. 10.3389/fphys.2014.00213.
32. Novakovic B., Sibson M., Ng H.K., Manuelpillai U., Rakyan V., Down T., et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: Implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. The Journal of Biological Chemistry 2009, 284(22):14838-14848. 10.1074/jbc.M809542200.
33. Ohyama Y., Noshiro M., Eggertsen G., Gotoh O., Kato Y., Bjorkhem I., et al. Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase. Biochemistry 1993, 32(1):76-82.
34. Perwad F., Portale A.A. Vitamin D metabolism in the kidney: Regulation by phosphorus and fibroblast growth factor 23. Molecular and Cellular Endocrinology 2011, 347(1-2):17-24. 10.1016/j.mce.2011.08.030.
35. Perwad F., Zhang M.Y., Tenenhouse H.S., Portale A.A. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro. American Journal of Physiology. Renal Physiology 2007, 293(5):F1577-F1583. 10.1152/ajprenal.00463.2006.
36. Petkovich M., Jones G. CYP24A1 and kidney disease. Current Opinion in Nephrology and Hypertension 2011, 20(4):337-344. 10.1097/MNH.0b013e3283477a7b.
37. Pettifor J.M., Thandrayen K. Hypophosphatemic rickets: Unraveling the role of FGF23. Calcified Tissue International 2012, 91(5):297-306. 10.1007/s00223-012-9651-0.
38. Pike J.W., Meyer M.B. The vitamin D receptor: New paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3). Endocrinology and Metabolism Clinics of North America 2010, 39(2):255-269. 10.1016/j.ecl.2010.02.007.
39. Pike J.W., Meyer M.B. Regulation of mouse Cyp24a1 expression via promoter-proximal and downstream-distal enhancers highlights new concepts of 1,25-dihydroxyvitamin D(3) action. Archives of Biochemistry and Biophysics 2012, 523(1):2-8. 10.1016/j.abb.2011.12.003.
40. Plum L.A., DeLuca H.F. Vitamin D, disease and therapeutic opportunities. Nature Reviews. Drug Discovery 2010, 9(12):941-955. 10.1038/nrd3318.
41. Prosser D.E., Kaufmann M., O'Leary B., Byford V., Jones G. Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(31):12673-12678. 10.1073/pnas.0702093104.
42. Raval-Pandya M., Dhawan P., Barletta F., Christakos S. YY1 represses vitamin D receptor-mediated 25-hydroxyvitamin D(3)24-hydroxylase transcription: Relief of repression by CREB-binding protein. Molecular Endocrinology 2001, 15(6):1035-1046. 10.1210/mend.15.6.0651.
43. Schlingmann K.P., Kaufmann M., Weber S., Irwin A., Goos C., John U., et al. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. The New England Journal of Medicine 2011, 365(5):410-421. 10.1056/NEJMoa1103864.
44. Seth-Vollenweider T., Joshi S., Dhawan P., Sif S., Christakos S. Novel mechanism of negative regulation of 1,25-dihydroxyvitamin D3-induced 25-hydroxyvitamin D3 24-hydroxylase (Cyp24a1) transcription: Epigenetic modification involving cross-talk between protein-arginine methyltransferase 5 and the SWI/SNF complex. The Journal of Biological Chemistry 2014, 289(49):33958-33970. 10.1074/jbc.M114.583302.
45. Shimada T., Kakitani M., Yamazaki Y., Hasegawa H., Takeuchi Y., Fujita T., et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. The Journal of Clinical Investigation 2004, 113(4):561-568. 10.1172/JCI19081.
46. Shinki T., Jin C.H., Nishimura A., Nagai Y., Ohyama Y., Noshiro M., et al. Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1 alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine. The Journal of Biological Chemistry 1992, 267(19):13757-13762.
47. Sitara D., Razzaque M.S., Hesse M., Yoganathan S., Taguchi T., Erben R.G., et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biology 2004, 23(7):421-432. 10.1016/j.matbio.2004.09.007.
48. St-Arnaud R. CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24. The Journal of Steroid Biochemistry and Molecular Biology 2010, 121(1-2):254-256. 10.1016/j.jsbmb.2010.02.002.
49. St-Arnaud R. Cyp24A1: Structure, function and physiological role. Vitamin D 2011, 43-56. Academic Press, New York, NY. 3rd ed. D. Feldman, J.W. Pike, J.S. Adams (Eds.).
50. St-Arnaud R., Arabian A., Travers R., Barletta F., Raval-Pandya M., Chapin K., et al. Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D. Endocrinology 2000, 141(7):2658-2666. 10.1210/endo.141.7.7579.
51. St-Arnaud R., Naja R.P. Vitamin D metabolism, cartilage and bone fracture repair. Molecular and Cellular Endocrinology 2011, 347(1-2):48-54. 10.1016/j.mce.2011.05.018.
52. Tebben P.J., Milliner D.S., Horst R.L., Harris P.C., Singh R.J., Wu Y., et al. Hypercalcemia, hypercalciuria, and elevated calcitriol concentrations with autosomal dominant transmission due to CYP24A1 mutations: Effects of ketoconazole therapy. The Journal of Clinical Endocrinology and Metabolism 2012, 97(3):E423-E427. 10.1210/jc.2011-1935.
53. Tsai K.S., Heath H., Kumar R., Riggs B.L. Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis. The Journal of Clinical Investigation 1984, 73(6):1668-1672. 10.1172/JCI111373.
54. van Abel M., Huybers S., Hoenderop J.G., van der Kemp A.W., van Leeuwen J.P., Bindels R.J. Age-dependent alterations in Ca2+ homeostasis: Role of TRPV5 and TRPV6. American Journal of Physiology. Renal Physiology 2006, 291(6):F1177-F1183. 10.1152/ajprenal.00038.2006.
55. Zehnder D., Evans K.N., Kilby M.D., Bulmer J.N., Innes B.A., Stewart P.M., et al. The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua. The American Journal of Pathology 2002, 161(1):105-114.
56. Zierold C., Mings J.A., DeLuca H.F. Parathyroid hormone regulates 25-hydroxyvitamin D(3)-24-hydroxylase mRNA by altering its stability. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(24):13572-13576. 10.1073/pnas.241516798.
57. Zierold C., Nehring J.A., DeLuca H.F. Nuclear receptor 4A2 and C/EBPbeta regulate the parathyroid hormone-mediated transcriptional regulation of the 25-hydroxyvitamin D3-1alpha-hydroxylase. Archives of Biochemistry and Biophysics 2007, 460(2):233-239. 10.1016/j.abb.2006.11.028.