Age-dependent alterations in Ca2+ homeostasis: Role of TRPV5 and TRPV6

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 6, 2006, Pages

  Van Abel, Monique ^a   Huybers, Sylvie ^a   Hoenderop, Joost G J ^a   Van Der Kemp, Annemiete W C M ^a   Van Leeuwen, Johannes P T M ^b   Bindels, René J M ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

1,25(OH)2D3; Aging; CaT1; ECaC; Osteoporosis; PTH; VDR

Indexed keywords

CALCITRIOL; CALCIUM; MESSENGER RNA; OSTEOCALCIN; PROTEIN TRPV5; PROTEIN TRPV6; VANILLOID RECEPTOR 1; VITAMIN D RECEPTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE TURNOVER; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; IMMUNOFLUORESCENCE TEST; INTESTINE ABSORPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 33845366513     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00038.2006     Document Type: Article

References (51)

1. Agus ZS, Gardner LB, Beck LH, and Goldberg M. Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am J Physiol 224: 1143-1148, 1973.
2. Armbrecht HJ, Boltz M, Strong R, Richardson A, Bruns MEH, and Christakos S. Expression of calbindin-D decreases with age in intestine and kidney. Endocrinology 125: 2950-2956, 1989.
3. Armbrecht HJ, Boltz MA, and Bruns ME. Effect of age and dietary calcium on intestinal calbindin D-9k expression in the rat. Arch Biochem Biophys 420: 194-200, 2003.
4. 3 decrease with age. Am J Physiol Gastrointest Liver Physiol 277: G41-G47, 1999.
5. 2D, and PTH. Am J Physiol Endocrinol Metab 246: E266-E270, 1984.
6. Armbrecht HJ, Zenser TV, Bruns MEH, and Davis BB. Effect of age on intestinal calcium absorption and adaptation to dietary calcium. Am J Physiol Endocrinol Metab Gastrointest Physiol 236: E769-E774, 1979.
7. Armbrecht HJ, Zenser TV, Gross CJ, and Davis BB. Adaptation to dietary calcium and phosphorus restriction changes with age in the rat. Am J Physiol Endocrinol Metab 239: E322-E327, 1980.
8. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, and Tenenhouse HS. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 95: 5372-5377, 1998.
9. 3 and PTH. Am J Physiol Renal Fluid Electrolyte Physiol 261: F799-F807, 1991.
10. Bindels RJM, Hartog A, Abrahamse SL, and Van Os CH. Effects of pH on apical calcium entry and active calcium transport in rabbit cortical collecting system. Am J Physiol Renal Fluid Electrolyte Physiol 266: F620-F627, 1994.
11. Brown AJ, Krits I, and Armbrecht HJ. Effect of age, vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels. Arch Biochem Biophys 437: 51-58, 2005.
12. Chapuy MC, Durr F, and Chapuy P. Age-related changes in parathyroid hormone and 25-hydroxycholecalciferol levels. J Gerontol 38: 19-22, 1983.
13. 3 level in the rat. J Bone Miner Res 14: 57-64, 1999.
14. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, and DeLuca HF. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest 64: 729-736, 1979.
15. Gentili C, Morelli S, and De Boland AR. Characterization of PTH/ PTHrP receptor in rat duodenum: effects of ageing. J Cell Biochem 88: 1157-1167, 2003.
16. Hanai H, Brennan DP, Cheng L, Goldman ME, Chorev M, Levine MA, Sacktor B, and Liang CT. Downregulation of parathyroid hormone receptors in renal membranes from aged rats. Am J Physiol Renal Fluid Electrolyte Physiol 259: F444-F450, 1990.
17. Hanai H, Ishida M, Liang CT, and Sacktor B. Parathyroid hormone increases sodium/calcium exchange activity in renal cells and the blunting of the response in aging. J Biol Chem 261: 5419-5425, 1986.
18. Hanai H, Liang CT, Cheng L, and Sacktor B. Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity. J Clin Invest 83: 268-277, 1989.
19. 2+ channel in rabbit kidney and intestine. J Am Soc Nephrol 11: 1171-1178, 2000.
20. Hoenderop JG, Muller D, Van Der Kemp AW, Hartog A, Suzuki M, Ishibashi K, Imai M, Sweep F, Willems PH, Van Os CH, and Bindels RJ. Calcitriol controls the epithelial calcium channel in kidney. J Am Soc Nephrol 12: 1342-1349, 2001.
21. 2+ reabsorption in the distal nephron. Annu Rev Physiol 64: 529-549, 2002.
22. 3-responsive epithelia. J Biol Chem 274: 8375-8378, 1999.
23. 2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112: 1906-1914, 2003.
24. 3-1α-hydroxylase knockout mice. FASEB J 16: 1398-1406, 2002.
25. Horst RL, Goff JP, and Reinhardt TA. Advancing age results in reduction of intestinal and bone 1,25-dihydroxyvitamin D receptor. Endocrinology 126: 1053-1057, 1990.
26. 3-regulated gene expression. Exp Gerontol 30: 631-643, 1995.
27. Keenan MJ, Hegsted M, Siver F, Mohan R, and Wozniak P. Recovery of rats from vitamin D-deficient mothers. Ann Nutr Metab 35: 315-327, 1991.
28. Li YC, Bolt MJ, Cao LP, and Sitrin MD. Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism. Am J Physiol Endocrinol Metab 281: E558-E564, 2001.
29. 3 receptor and vitamin D-dependent calcium binding protein in aged Wistar rats. Exp Gerontol 29: 179-186, 1994.
30. Massheimer V, Picotto G, Boland R, and De Boland AR. Effect of aging on the mechanism of PTH-induced calcium influx in rat intestinal cells. J Cell Physiol 182: 429-437, 2000.
31. Melton L Jr, Atkinson EJ, O'Fallon WM, Wahner HW, and Riggs BL. Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8: 1227-1233, 1993.
32. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, and Zhu MX. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 9: 229-231, 2002.
33. Naveh-Many T, Rahamimov R, Livni N, and Silver J. Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D. J Clin Invest 96: 1786-1793, 1995.
34. 2+ channel TRPV6 in the kidney. J Am Soc Nephrol 14: 2731-2740, 2003.
35. Nordin BE, Horowitz M, Need A, and Morris HA. Renal leak of calcium in post-menopausal osteoporosis. Clin Endocrinol 41: 41-45, 1994.
36. Orwoll ES and Meier DE. Alterations in calcium, vitamin D, and parathyroid hormone physiology in normal men with aging: relationship to the development of senile osteopenia. J Clin Endocrinol Metab 63: 1262-1269, 1986.
37. Partridge NC, Bloch SR, and Pearman AT. Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression. J Cell Biochem 55: 321-327, 1994.
38. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, and Hediger MA. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem 274: 22739-22746, 1999.
39. Picotto G, Massheimer V, and Boland R. Parathyroid hormone stimulates calcium influx and the cAMP messenger system in rat enterocytes. Am J Physiol Cell Physiol 273: C1349-C1353, 1997.
40. 2+ hyperabsorption in TRPV5 knockout mice. J Am Soc Nephrol 16: 3188-3195, 2005.
41. Schapira D, Linn S, Sarid M, Mokadi S, Kabala A, and Silbermann M. Calcium and vitamin D enriched diets increase and preserve vertebral mineral content in aging laboratory rats. Bone 16: 575-582, 1995.
42. Sherman SS, Tobin JD, Hollis BW, Gundberg CM, Roy TA, and Plato CC. Biochemical parameters associated with low bone density in healthy men and women. J Bone Miner Res 7: 1123-1130, 1992.
43. 3 receptors in Wistar rats. Biochim Biophys Acta 1034: 22-28, 1990.
44. Teitelbaum SL. Bone resorption by osteoclasts. Science 289: 1504-1508, 2000.
45. 2+ channels in small intestine as studied by quantitative mRNA detection. Am J Physiol Gastrointest Liver Physiol 285: G78-G85, 2003.
46. 3-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney. J Am Soc Nephrol 13: 2102-2109, 2002.
47. 2+ transport proteins by parathyroid hormone. Kidney Int 68: 1708-1721, 2005.
48. Van Baal J, Yu A, Hartog A, Fransen JA, Willems PH, Lytton J, and Bindels RJ. Localization and regulation by vitamin D of calcium transport proteins in rabbit cortical collecting system. Am J Physiol Renal Fluid Electrolyte Physiol 271: F985-F993, 1996.
49. Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van Herck E, Kato S, Bindels RJ, Collen D, Carmeliet P, Bouillon R, and Carmeliet G. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci USA 98: 13324-13329, 2001.
50. Verhaeghe J, Van Herck E, Van Bree R, Van Assche FA, and Bouillon R. Osteocalcin during the reproductive cycle in normal and diabetic rats. J Endocrinol 120: 143-151, 1989.
51. 2+-sensing receptor mRNAs along the rat nephron. Am J Physiol Renal Physiol 272: F751-F758, 1997.