XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

Cell Death and Differentiation

Volumn 22, Issue 6, 2015, Pages 890-897

  Craxton, A ^a   Somers, J ^a   Munnur, D ^a   Jukes Jones, R ^a   Cain, K ^a   Malewicz, M ^a  

^a MRC TOXICOLOGY UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; PAXX PROTEIN, HUMAN; SMALL INTERFERING RNA;

AFFINITY CHROMATOGRAPHY; CELL LINE; COMPUTER SIMULATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENETICS; HUMAN; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY; TANDEM MASS SPECTROMETRY;

CELL LINE; CHROMATOGRAPHY, AFFINITY; COMPUTER SIMULATION; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; IMMUNOBLOTTING; RNA, SMALL INTERFERING; TANDEM MASS SPECTROMETRY;

EID: 84939946728     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.22     Document Type: Article

References (32)

1. Bekker-Jensen S, Mailand N. Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amst) 2010; 9: 1219-1228.
2. Grundy GJ, Moulding HA, Caldecott KW, Rulten SL. One ring to bring them all-the role of Ku in mammalian non-homologous end joining. DNA Repair (Amst) 2014; 17: 30-38.
3. Ciccia A, Elledge SJ. The DNA damage response: Making it safe to play with knives. Mol Cell 2010; 40: 179-204.
4. Pannunzio NR, Li S, Watanabe G, Lieber MR. Non-homologous end joining often uses microhomology: Implications for alternative end joining. DNA Repair (Amst) 2014; 17: 74-80.
5. Frit P, Barboule N, Yuan Y, Gomez D, Calsou P. Alternative end-joining pathway(s): Bricolage at DNA breaks. DNA Repair (Amst) 2014; 17: 81-97.
6. Waters CA, Strande NT, Wyatt DW, Pryor JM, Ramsden DA. Nonhomologous end joining: A good solution for bad ends. DNA Repair (Amst) 2014; 17: 39-51.
7. Woodbine L, Gennery AR, Jeggo PA. The clinical impact of deficiency in DNA non-homologous end-joining. DNA Repair (Amst) 2014; 16: 84-96.
8. Davis AJ, Chen BP, Chen DJ. DNA-PK: A dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) 2014; 17: 21-29.
9. Ochi T, Wu Q, Blundell TL. The spatial organization of non-homologous end joining: From bridging to end joining. DNA Repair (Amst) 2014; 17: 98-109.
10. Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA. XLF regulates filament architecture of the XRCC4.ligase IV complex. Structure 2010; 18: 1431-1442.
11. Ahnesorg P, Smith P, Jackson SP. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 2006; 124: 301-313.
12. Buck D, Malivert L, De Chasseval R, Barraud A, Fondaneche MC, Sanal O et al. Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell 2006; 124: 287-299.
13. Ma Y, Pannicke U, Schwarz K, Lieber MR. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 2002; 108: 781-794.
14. Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Mol Cell Biol 2010; 30: 1368-1381.
15. Kelley LA, Sternberg MJ. Protein structure prediction on the Web: A case study using the Phyre server. Nat Protoc 2009; 4: 363-371.
16. Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J et al. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 2006; 173: 195-206.
17. Jackson SP. Colworth Medal lecture. Detection, repair and signalling of DNA doublestrand breaks. Biochem Soc Trans 1999; 27: 1-13.
18. Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M et al. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 1997; 388: 492-495.
19. Rulten SL, Fisher AE, Robert I, Zuma MC, Rouleau M, Ju L et al. PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell 2011; 41: 33-45.
20. Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K et al. Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev 2011; 25: 2031-2040.
21. Fattah FJ, Kweon J, Wang Y, Lee EH, Kan Y, Lichter N et al. A role for XLF in DNA repair and recombination in human somatic cells. DNA Repair (Amst) 2014; 15: 39-53.
22. Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences. Adv Immunol 2005; 86: 43-112.
23. Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N et al. DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science 2015; 347: 185-188.
24. Boyd RS, Jukes-Jones R, Walewska R, Brown D, Dyer MJ, Cain K. Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma. Mol Cell Proteom 2009; 8: 1501-1515.
25. Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L et al. A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Mol Cell 2012; 47: 291-305.
26. Distler U, Kuharev J, Navarro P, Levin Y, Schild H, Tenzer S. Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics. Nat Methods 2014; 11: 167-170.
27. Silva JC, Denny R, Dorschel C, Gorenstein MV, Li GZ, Richardson K et al. Simultaneous qualitative and quantitative analysis of the Escherichia coli proteome: A sweet tale. Mol Cell Proteom 2006; 5: 589-607.
28. Junop MS, Modesti M, Guarne A, Ghirlando R, Gellert M, Yang W. Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J 2000; 19: 5962-5970.
29. Andres SN, Modesti M, Tsai CJ, Chu G, Junop MS. Crystal structure of human XLF: A twist in nonhomologous DNA end-joining. Mol Cell 2007; 28: 1093-1101.
30. Guzman C, Bagga M, Kaur A, Westermarck J, Abankwa D. ColonyArea: An ImageJ plugin to automatically quantify colony formation in clonogenic assays. PloS One 2014; 9: E92444.
31. Qiu H, Durand K, Rabinovitch-Chable H, Rigaud M, Gazaille V, Clavere P et al. Gene expression of HIF-1alpha and XRCC4 measured in human samples by real-time RT-PCR using the sigmoidal curve-fitting method. BioTechniques 2007; 42: 355-362.
32. Crispi S, Calogero RA, Santini M, Mellone P, Vincenzi B, Citro G et al. Global gene expression profiling of human pleural mesotheliomas: Identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target. PLoS One 2009; 4: E7016.