Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

BMC Biology

Volumn 14, Issue 1, 2016, Pages

  Bridges, Hannah R ^a   Sirviö, Ville A ^a   Agip, Ahmed Noor A ^a   Hirst, Judy ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

AMP kinase; Biguanide; Metformin; NADH:ubiquinone oxidoreductase; Respiratory complex I

Indexed keywords

ADENYLATE KINASE; BIGUANIDE DERIVATIVE; PHENFORMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE;

ANIMAL; BOVINE; CELL MEMBRANE PERMEABILITY; CELL RESPIRATION; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; OXYGEN CONSUMPTION; RAT; SOLUBILITY; TUMOR CELL LINE;

ADENYLATE KINASE; ANIMALS; BIGUANIDES; CATTLE; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL RESPIRATION; ELECTRON TRANSPORT COMPLEX I; ENZYME ACTIVATION; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; OXYGEN CONSUMPTION; PHENFORMIN; RATS; ROTENONE; SOLUBILITY;

EID: 84991795092     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/s12915-016-0287-9     Document Type: Article

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